Quantitative evaluation of astrocyte densities in schizophrenia

Falkai, P.; David, S.R.; Bogerts, B.; Tapernon-Franz, U.

doi:10.1016/0920-9964(91)90281-u

Cited by 4 publications

(1 citation statement)

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“…However, there are several reports of gliosis, especially in subcortical and periventricular areas, in brains from varying percentages of patients diagnosed with schizophrenia. These reports include not only qualitative results (Winkelman and Book 1949; Nieto and Escobar 1972; Fisman 1975; Stevens 1982; Bruton et al 1990), but also quantitative studies (Blinkov and Glezer 1968; Falkai et al 1991; Arnold et al 1996). Although Roberts et al (1986) found no statistical difference in averaged density of glial fibrillary acid protein (GFAP) staining in a comparison of subcortical and cortical regions of pooled schizophrenia and control brains, densitometry readings were higher in the schizophrenia brains in every region studied especially in subcortical areas.…”

Section: Which Brain Structures Are Responsible For Expansion Of the ...mentioning

confidence: 99%

Anatomy of Schizophrenia Revisited

Stevens

1997

Schizophrenia Bulletin

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The search for an anatomy of schizophrenia has engendered an enormous, almost indigestible mass of data. In no studies do all patients show the same deviations from control samples. No morphological or microscopic abnormality has been found that is either necessary or sufficient for the diagnosis. In contrast to epilepsy, in which a proliferation of excitatory pathways or inadequate inhibitory factors are paramount, schizophrenia may represent a genetically and age-determined elaboration of one or more inhibitory networks in response to specific physiological events (e.g., the increased neuronal activity in limbic and hypothalamic structures during the physiological events of puberty) or to brain injury or defect. Current diagnostic classifications, including the positive-negative categories, have not led to separation of the disorder into etiologically or pathologically similar subgroups. Analysis of morphological and other biological pathology by a different nosological principle, such as trajectory of the illness, and separate correlation of anatomical and other biological outliers with clinical and demographic factors may be more successful strategies than pooling and averaging results from a mixture of patients diagnosed with schizophrenia.

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