Quantitative evaluation of bioaerosols in different particle size fractions in dust collected on the International Space Station (ISS)

Haines, Sarah R.; Bope, Ashleigh; Horack, John M.; Meyer, Marit E.; Dannemiller, Karen C.

doi:10.1007/s00253-019-10053-4

Cited by 15 publications

(20 citation statements)

References 78 publications

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“…17 In microgravity, owing to the lack of gravitational settling, particulates remain airborne until they are trapped by ISS filters. 17 These particulates include bioaerosols created from coughing or sneezing or during speech, increasing the risk of person-to-person transmission of viruses and other microbial agents. 18 Bacterial and fungal growths have been found on ISS surfaces and within free-floating condensates.…”

Section: Eustachian Tube Dysfunctionmentioning

confidence: 99%

Spaceflight-Associated Changes in the Opacification of the Paranasal Sinuses and Mastoid Air Cells in Astronauts

Inglesby

Antonucci

Spampinato

et al. 2020

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Head congestion is one of the most common somatic symptoms experienced by astronauts during spaceflight; however, changes in the opacification of the paranasal sinuses or mastoid air cells in astronauts have not been adequately studied.OBJECTIVES To quantify preflight to postflight changes in the opacification of the paranasal sinuses and mastoid air cells in Space Shuttle astronauts and International Space Station (ISS) astronauts and to assess whether there are differences between the 2 groups of astronauts. DESIGN, SETTING, AND PARTICIPANTSThis cohort study examined preflight and postflight head magnetic resonance images (MRIs) of 35 astronauts who had participated in either a short-duration (Յ30 days) Space Shuttle mission or a long-duration (>30 days) ISS mission and had undergone both preflight and postflight MRI. Images were obtained before and after spaceflight. Images were evaluated by 2 neuroradiologists blinded to which mission each astronaut had flown and to which images were preflight or postflight images. EXPOSURE Spaceflight on the Space Shuttle or the ISS. MAIN OUTCOMES AND MEASURES Measured outcomes included preflight to postflight changes in Lund-Mackay scores for the paranasal sinuses and in scores grading mastoid effusions. RESULTS Most astronauts in both the Space Shuttle group (n = 17; 15 men; mean [SD] age at launch, 47.7 [3.1] years) and the ISS group (n = 18; 14 men; mean [SD] age at launch, 48.6 [4.7] years) exhibited either no change or a reduction in paranasal sinus opacification as seen on postflight MRI scans (Space Shuttle group: 6 [35.3%] had no sinus opacification before or after spaceflight, 5 [29.4%] had less sinus opacification after spaceflight, 3 [17.6%] had the same amount of sinus opacification before and after spaceflight, and 3 [17.6%] had increased paranasal sinus opacification after spaceflight; ISS group: 8 [44.4%] had no sinus opacification before or after spaceflight, 4 [22.2%] had less sinus opacification after spaceflight, 1 (5.6%) had the same amount of sinus opacification before and after spaceflight, and 5 [27.8%] had scores consistent with increased paranasal sinus opacification after spaceflight). Long-duration spaceflight (ISS group) was associated with an increased risk of mastoid effusion relative to short-duration spaceflight (relative risk, 4.72; 95% CI, 1.2-18.5). Images were obtained a mean (SD) 287.5 (208.6) days (range, 18-627 days) prior to and 6.8 (5.8) days (range, 1-20 days) after spaceflight. Astronauts had undergone either a mean (SD) of 13.6 (1.6) days of spaceflight on the Space Shuttle (17 astronauts) or 164.8 (18.9) days on the ISS (18 astronauts). CONCLUSIONS AND RELEVANCEThis study found that exposure to spaceflight conditions on the ISS is associated with an increased likelihood for the formation of mastoid effusions. There was no association between exposure to spaceflight conditions and changes in paranasal sinus opacification. The limitations of this study include lack of information concerning medical history and mission-sp...

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Section: Eustachian Tube Dysfunctionmentioning

confidence: 99%

Spaceflight-Associated Changes in the Opacification of the Paranasal Sinuses and Mastoid Air Cells in Astronauts

Inglesby

Antonucci

Spampinato

et al. 2020

JAMA Otolaryngol Head Neck Surg

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“…8,10,11 Furthermore, robust biosurveillance systems can track mutations and shifts in the genomics and proteomics of spreading pathogens; 10 and even help to guard against catastrophic spreading situations in enclosed environments, such as the International Space Station and future human habitations on the moon and Mars, where bioaerosol dynamics and microbial growth are much different from on Earth. 12,13 Critically, knowledge of the presence of airborne pathogens will continue to become increasingly important as changing climate patterns drive a shift in microbial distribution. 14 To gain information about bioaerosols, two main types of samplers are typically used, depending on the deployment environment and desired analysis.…”

Section: Introductionmentioning

confidence: 99%

Improved recovery of captured airborne bacteria and viruses with liquid-coated air filters

Regan

Fong

Bond

et al. 2022

Preprint

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The COVID-19 pandemic has revealed the importance of the detection of airborne pathogens. Here, we present composite air filters featuring a bio-inspired liquid coating that facilitates the removal of captured aerosolized bacteria and viruses for further analysis. We tested three types of air filters: commercial polytetrafluoroethylene (PTFE), which is well-known for creating stable liquid coatings, commercial high-efficiency particulate air (HEPA) filters, which are widely used, and in-house manufactured cellulose nanofiber mats (CNFM), which are made from sustainable materials. All filters were coated with omniphobic fluorinated liquid to maximize release. We found that coating both the PTFE and HEPA filters with liquid improved the rate at which Escherichia coli was recovered using a physical removal process compared to uncoated controls. Notably, the coated HEPA filters also increased the total number of recovered cells by 57%. Coating the CNFM filters did not improve either the rate of release or total number of captured cells. The ability of the highest performance materials, the liquid-coated HEPA filters were next evaluated on their ability to facilitate the removal of pathogenic viruses via a chemical removal process. Recovery of infectious JC polyomavirus, a non-enveloped virus which attacks the central nervous system, was increased by 92% over uncoated controls; however, there was no significant difference in the total amount of RNA recovered compared to controls. In contrast, significantly more RNA was recovered for SARS-CoV-2, the airborne, enveloped virus which causes COVID-19, from liquid-coated filters. Although the amount of infectious SARS-CoV-2 recovered was 58% higher, these results were not significantly different from uncoated filters due to high variability. These results suggest that the efficient recovery of airborne pathogens from filters could improve air sampling efforts, enhancing biosurveillance and global pathogen early warning.

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“…In addition to various metals, microbial corrosion can also damage plastics and other surfaces (Videla & Herrera, 2005, Li et al, 2013a, Little et al, 1992. The most sensitive life support systems are the drinking water system (Thornhill & Kumar, 2018), the ventilation system (Haines et al, 2019, Checinska Sielaff et al, 2016 as well as the heating and electricity supply. Clogging of water leading pipelines or the ventilation system could lead to an emergency forcing to evacuate the ISS.…”

Section: Microbial Burden In Spacementioning

confidence: 99%

Bacillus subtilis biofilm formation under extreme terrestrial and simulated extraterrestrial conditions

Fuchs¹

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Quantitative evaluation of bioaerosols in different particle size fractions in dust collected on the International Space Station (ISS)

Cited by 15 publications

References 78 publications

Spaceflight-Associated Changes in the Opacification of the Paranasal Sinuses and Mastoid Air Cells in Astronauts

Spaceflight-Associated Changes in the Opacification of the Paranasal Sinuses and Mastoid Air Cells in Astronauts

Improved recovery of captured airborne bacteria and viruses with liquid-coated air filters

Bacillus subtilis biofilm formation under extreme terrestrial and simulated extraterrestrial conditions

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