Quantitative evaluation of kneading and extrusion processes by pressure transmission characteristics of wet kneaded masses

Watano, Satoru; Furukawa, Jyunpei; Miyanami, Kei; Osako, Yoshifumi

doi:10.1163/156855201750537947

Cited by 15 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These systems are or become heterogeneous melt reactions that require kneading techniques if they are to occur under solvent-free conditions and cannot be performed in a beaker or flask because of mixing problems. While technical kneading is available, [6] laboratory-scale vibration ball-mills with comparatively large balls and temperature control for sufficiently low viscosity can be successfully used for the kneading action in these cases. This procedure is solventfree kneading ball-milling and is different to the kneading of solids after the addition of some solvent but not enough to dissolve them completely, [21] which, however, is not a solventfree technique.…”

Section: Resultsmentioning

confidence: 99%

“…[1][2][3][4] These solidsolid reactions are comparable to melt reactions at higher temperatures, although there is a risk of inferior results because the benefit of self-assembled packing is lost. [5] Nevertheless, there is also an urgency for solvent-free reactions under efficient kneading conditions [6] in the absence of solvents, because many useful reagents do not have sufficiently high melting points and many melt reactions at high viscosity suffer from inefficient mixing of the reaction partners. Important targets are the versatile oximes and arylhydrazones because of their high synthetic potential for transformations to nitriles, nitro compounds, nitrones, amines, amides, nitrile oxides, and others, [7][8] or heterocycles such as pyrazoles, triazoles, formazanes, or hydrazines, nitrile imines, and others.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Kneading Ball‐Milling and Stoichiometric Melts for the Quantitative Derivatization of Carbonyl Compounds with Gas–Solid Recovery

et al. 2009

View full text Add to dashboard Cite

A ray of hope for the environment is sustainable and green synthesis without the production of (toxic) waste. Solvent-free stoichiometric melting or kneading ball-milling reactions of aldehydes or ketones with carbonyl reagents yields arylhydrazones and oximes in quantitative yield. The carbonyl compounds can be quantitatively recovered from the imino derivatives by using gaseous NO(2).An effective methodology of kneading with a ball mill under temperature control was used for the stoichiometric quantitative preparation of synthetically versatile oximes and 2,4-dinitrophenylhydrazones from low-melting aldehydes and ketones. Also, a large number of phenylhydrazones are obtained by safe stoichiometric quantitative melt reactions. Advantages of this technique are short reaction times, eco-friendliness, and ease of handling under solvent-free conditions, as no waste-producing purifying workup is necessary. The different reactivities of aldehydes and ketones allow for easy separation of mixtures containing aldehydes and ketones. Furthermore, a new effective, gas-solid deprotection methodology for oximes was developed, using nitrogen dioxide as the reagent under solvent-free conditions to recover the aldehydes or ketones. The corresponding aldehydes were obtained free of overoxidized acids in quantitative yields.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Kneading Ball‐Milling and Stoichiometric Melts for the Quantitative Derivatization of Carbonyl Compounds with Gas–Solid Recovery

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Studies on kneading and on the development of laboratory/industrial “kneaders” (mainly of pharmaceutical powders) have been carried out 46. 47…”

Section: Intersolid Reactionsmentioning

confidence: 99%

Reactions Between or Within Molecular Crystals

2004

View full text Add to dashboard Cite

Reactions that occur within or between molecular crystals, in particular those reactions that are activated by mechanical methods, are reviewed. The focus is on processes (whether intrasolid or intersolid) that are controlled primarily by supramolecular bonding, such as template cycloadditions, formation of inclusion compounds, reactions between molecular crystals by the reassembling of noncovalent bonds, and the formation of complexes and coordination compounds. It is proposed that solvent-free mechanochemical methods, for example, cogrinding, milling, and kneading, represent viable "green" routes for the preparation of novel molecular and supramolecular solids.

show abstract

“…Der Knetvorgang ist gut untersucht, und diverse Labor‐ und Industrieknetmaschinen (hauptsächlich für pharmazeutische Pulver) sind entwickelt worden 46. 47…”

Section: Reaktionen Zwischen Feststoffenunclassified

Reaktionen zwischen und in Molekülkristallen

Braga

Grepioni

2004

Angewandte Chemie

View full text Add to dashboard Cite

Reaktionen in und zwischen Molekülkristallen, insbesondere mechanisch ausgelöste Umsetzungen, werden in diesem Kurzaufsatz diskutiert. Den Schwerpunkt bilden Prozesse innerhalb oder zwischen Festkörpern, die vor allem durch supramolekulare Wechselwirkungen gesteuert werden: Templatcycloadditionen, Bildung von Einschlussverbindungen, Reaktionen von Molekülkristallen mit Umorganisation nichtkovalenter Bindungen und Bildung von Komplexen und Koordinationsverbindungen. Lösungsmittelfreie mechanochemische Verfahren wie Mahlen und Kneten bieten sich als umweltschonende Methoden zur Synthese von molekularen und supramolekularen Feststoffen an.

show abstract

Quantitative evaluation of kneading and extrusion processes by pressure transmission characteristics of wet kneaded masses

Cited by 15 publications

References 2 publications

Kneading Ball‐Milling and Stoichiometric Melts for the Quantitative Derivatization of Carbonyl Compounds with Gas–Solid Recovery

Kneading Ball‐Milling and Stoichiometric Melts for the Quantitative Derivatization of Carbonyl Compounds with Gas–Solid Recovery

Reactions Between or Within Molecular Crystals

Reaktionen zwischen und in Molekülkristallen

Contact Info

Product

Resources

About