Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation

Kim, Kyung-Ah; Park, Mi-Suk; Kim, In-Seong; Kiefer, Berthold; Chung, Woo-Suk; Kim, Do Young; Kim, Ki Whang

doi:10.1002/jmri.23620

Cited by 58 publications

(58 citation statements)

References 28 publications

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“…An interesting finding in both our phantom and in vivo studies is that, unlike conventional methods, which typically show a dependence of T1 on the B 1 , the proposed FISP MR fingerprinting technique consistently exhibits a dependence of T2 on B 1 . This difference is likely due to the distinct T1 metastatic adenocarcinoma were 1673 msec 6 331 and 43 msec 6 13, respectively-significantly higher than those in the surrounding liver parenchyma (T1, msec 840 6 113 [P , .0001]; T2, 28 msec 6 3 [P , .01]) and in asymptomatic volunteers (Table 2) (P , .0001 for T1 and P = .021 for T2).…”

Section: Resultsmentioning

confidence: 60%

MR Fingerprinting for Rapid Quantitative Abdominal Imaging

Chen¹,

Jiang²,

Pahwa³

et al. 2016

Radiology

192

228

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).q RSNA, 2016 Purpose:To develop a magnetic resonance (MR) "fingerprinting" technique for quantitative abdominal imaging. Materials and Methods:This HIPAA-compliant study had institutional review board approval, and informed consent was obtained from all subjects. To achieve accurate quantification in the presence of marked B 0 and B 1 field inhomogeneities, the MR fingerprinting framework was extended by using a twodimensional fast imaging with steady-state free precession, or FISP, acquisition and a Bloch-Siegert B 1 mapping method. The accuracy of the proposed technique was validated by using agarose phantoms. Quantitative measurements were performed in eight asymptomatic subjects and in six patients with 20 focal liver lesions. A two-tailed Student t test was used to compare the T1 and T2 results in metastatic adenocarcinoma with those in surrounding liver parenchyma and healthy subjects. Results:Phantom experiments showed good agreement with standard methods in T1 and T2 after B 1 correction. In vivo studies demonstrated that quantitative T1, T2, and B 1 maps can be acquired within a breath hold of approximately 19 seconds. T1 and T2 measurements were compatible with those in the literature. Representative values included the following: liver, 745 msec 6 65 (standard deviation) and 31 msec 6 6; renal medulla, 1702 msec 6 205 and 60 msec 6 21; renal cortex, 1314 msec 6 77 and 47 msec 6 10; spleen, 1232 msec 6 92 and 60 msec 6 19; skeletal muscle, 1100 msec 6 59 and 44 msec 6 9; and fat, 253 msec 6 42 and 77 msec 6 16, respectively. T1 and T2 in metastatic adenocarcinoma were 1673 msec 6 331 and 43 msec 6 13, respectively, significantly different from surrounding liver parenchyma relaxation times of 840 msec 6 113 and 28 msec 6 3 (P , .0001 and P , .01) and those in hepatic parenchyma in healthy volunteers (745 msec 6 65 and 31 msec 6 6, P , .0001 and P = .021, respectively). Conclusion:A rapid technique for quantitative abdominal imaging was developed that allows simultaneous quantification of multiple tissue properties within one 19-second breath hold, with measurements comparable to those in published literature.q RSNA, 2016

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Section: Resultsmentioning

confidence: 60%

MR Fingerprinting for Rapid Quantitative Abdominal Imaging

Chen¹,

Jiang²,

Pahwa³

et al. 2016

Radiology

192

228

View full text Add to dashboard Cite

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“…However, in the clinical situation, liver cirrhosis is a chronic condition that is not commonly combined with edema and acute inflammation. In contrast, other previous studies did not observe a correlation between liver disease and the T1 relaxation times, and some showed a decrease in the unenhanced T1 relaxation time with an increasing degree of cirrhosis373839 These controversial findings indicate that non-enhanced T1 relaxometry is unlikely to be an appropriate method for detecting and staging liver disease.…”

Section: Discussionmentioning

confidence: 61%

MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score

Haimerl

Verloh

Fellner

et al. 2014

Sci Rep

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Gd-EOB-DTPA is a hepatocyte-specific MRI contrast agent. Due to its hepatocyte-specific uptake and paramagnetic properties, functioning areas of the liver exhibit shortening of the T1 relaxation time. We report the potential use of T1 relaxometry of the liver with Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) for estimating the liver function as expressed by the MELD score. 3 T MRI relaxometry was performed before and 20 min after Gd-EOB-DTPA administration. A strong correlation between changes in the T1 relaxometry and the extent of liver disease, expressed by the MELD score, was documented. Reduced liver function correlates with decreased Gd-EOB-DTPA accumulation in the hepatocytes during the hepatobiliary phase. MRI-based T1 relaxometry with Gd-EOB-DTPA may be a useful method for assessing overall and segmental liver function.

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“…12 One of the first studies using T 1 mapping in the abdomen was done for detection of liver fibrosis. 13 …”

Section: Discussionmentioning

confidence: 99%

T₁ mapping for diagnosis of mild chronic pancreatitis

Tirkes

Lin

Fogel

et al. 2016

Magnetic Resonance Imaging

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Purpose To determine if the T1 relaxation time of the pancreas can detect parenchymal changes in mild chronic pancreatitis (CP). Materials and Methods This Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study analyzed 98 patients with suspected mild CP. Patients were grouped as normal (n = 53) or mild CP (n = 45) based on history, presenting symptomatology, and concordant findings on both the secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) and endoscopic retrograde cholangiopancreatography (ERCP). T1 maps were obtained in all patients using the same 3D gradient echo technique on the same 3T scanner. T1 relaxation times, fat signal fraction (FSF), and anterior–posterior (AP) diameter were correlated with the clinical diagnosis of CP. Results There was a significant difference (P < 0.0001) in the T1 relaxation times between the control (mean = 797 msec, 95% confidence interval [CI]: 730, 865) and mild CP group (mean = 1099 msec, 95% CI: 1032, 1166). A T1 relaxation time threshold value of 900 msec was 80% sensitive (95% CI: 65, 90) and 69% specific (95% CI: 56, 82) for the diagnosis of mild CP (area under the curve [AUC]: 0.81). Multiple regression analysis showed that T1 relaxation time was the only statistically significant variable correlating with the diagnosis of CP (P < 0.0001). T1 relaxation times showed a weak positive correlation with the pancreatic FSF (ρ = 0.33, P = 0.01) in the control group, but not in the mild CP group. Conclusion The T1 relaxation time of the pancreatic parenchyma was significantly increased in patients with mild CP. Therefore, T1 mapping might be used as a practical quantitative imaging technique for the evaluation of suspected mild CP.

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Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation

Cited by 58 publications

References 28 publications

MR Fingerprinting for Rapid Quantitative Abdominal Imaging

MR Fingerprinting for Rapid Quantitative Abdominal Imaging

MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score

T₁ mapping for diagnosis of mild chronic pancreatitis

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Quantitative evaluation of liver cirrhosis using T1 relaxation time with 3 tesla MRI before and after oxygen inhalation

Cited by 58 publications

References 28 publications

MR Fingerprinting for Rapid Quantitative Abdominal Imaging

MR Fingerprinting for Rapid Quantitative Abdominal Imaging

MRI-based estimation of liver function: Gd-EOB-DTPA-enhanced T1 relaxometry of 3T vs. the MELD score

T1 mapping for diagnosis of mild chronic pancreatitis

Contact Info

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T₁ mapping for diagnosis of mild chronic pancreatitis