Quantitative evaluation of oxygen metabolism in the intratumoral hypoxia: 18F-fluoromisonidazole and 15O-labelled gases inhalation PET

Watabe, Tadashi; Kanai, Yasukazu; Ikeda, Hayato; Horitsugi, Genki; Matsunaga, Keiko; Kato, Hirohisa; Isohashi, Kayako; Abe, Kohji; Shimosegawa, Eku; Hatazawa, Jun

doi:10.1186/s13550-017-0263-6

Cited by 11 publications

(13 citation statements)

References 31 publications

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“…Theoretically, 16:1 might be expected by biochemistry in anoxic tissue. The discrepancy can be explained by 1) limited spatial resolution of PET showing a mixture of hypoxic and non-hypoxic cells, not anoxic (only hypoxic, FMISO starts accumulation below an oxygen level of 10 mmHg), 2) hypoxia may reduce metabolism and increase oxygen extraction fraction [29], 3) in hypoxic area, necrosis is developing and cell density is decreasing, FDG uptake may be decreased, 4) FDG uptake does not completely reflect the entire process of glycolysis, but rather reflects glucose transporters and the hexokinase activity only [30].…”

Section: Discussionmentioning

confidence: 99%

Voxel based comparison and texture analysis of 18F-FDG and 18F-FMISO PET of patients with head-and-neck cancer

et al. 2019

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Background Hypoxia can induce radiation resistance and is an independent prognostic marker for outcome in head and neck cancer. As 18 F-FMISO (FMISO), a hypoxia tracer for PET, is far less common than 18 F-FDG (FDG) and two separate PET scans result in doubled cost and radiation exposure to the patient, we aimed to predict hypoxia from FDG PET with new techniques of voxel based analysis and texture analysis. Methods Thirty-eight patients with head-and-neck cancer underwent consecutive FDG and FMISO PET scans before any treatment. ROIs enclosing the primary cancer were compared in a voxel-by-voxel manner between FDG and FMISO PET. Tumour hypoxia was defined as the volume with a tumour-to-muscle ratio (TMR) > 1.25 in the FMISO PET and hypermetabolic volume was defined as >50% SUVmax in the FDG PET. The concordance rate was defined as percentage of voxels within the tumour which were both hypermetabolic and hypoxic. 38 different texture analysis (TA) parameters were computed based on the ROIs and correlated with presence of hypoxia. Results Within the hypoxic tumour regions, the FDG uptake was twice as high as in the non-hypoxic tumour regions (SUVmean 10.9 vs. 5.4; p<0.001). A moderate correlation between FDG and FMISO uptake was found by a voxel-by-voxel comparison (r = 0.664 p<0.001). The average concordance rate was 25% (± 22%). Entropy was the TA parameter showing the highest correlation with hypoxia (r = 0.524 p<0.001). Conclusion FDG uptake was higher in hypoxic tumour regions than in non-hypoxic regions as expected by tumour biology. A moderate correlation between FDG and FMISO PET was found by voxel-based analysis. TA yielded similar results in FDG and FMISO PET. However, it may not be possible to predict tumour hypoxia even with the help of texture analysis.

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Section: Discussionmentioning

confidence: 99%

Voxel based comparison and texture analysis of 18F-FDG and 18F-FMISO PET of patients with head-and-neck cancer

et al. 2019

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“…We recently reported about the intratumoral heterogeneity with hypoxic and necrotic regions in the C6 glioma xenograft by comparing 18 F-FMISO and 15 O-labeled gas PET to histological analysis [ 11 ]. Another previous study reported the characteristic difference in the tumor xenograft by comparing three tumor cell lines [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

et al. 2017

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PurposeThe purpose of this study was to establish a practical method to estimate the absolute boron concentrations in the tissues based on the standardized uptake values (SUVs) after administration of 4-borono-phenylalanine (BPA) using 4-borono-2-18F-fluoro-phenylalanine (18F-FBPA) PET.MethodsRat xenograft models of C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for the study. PET was performed 60 min after intravenous injection of 18F-FBPA (30.5 ± 0.7 MBq). After the PET scanning, BPA-fructose (167.3 ± 18.65 mg/kg) was administered by slow intravenous injection to the same subjects. The rats were killed 60 min after the BPA injection and tissue samples were collected from the major organs and tumors. The absolute boron concentrations (unit: ppm) in the samples were measured by inductively coupled plasma optical emission spectrometry (ICP-OES). The boron concentrations in the tissues/tumors were also estimated from the 18F-FBPA PET images using the following formula: estimated absolute boron concentration (ppm) = 0.0478 × [BPA dose (mg/kg)] × SUV. The measured absolute boron concentrations (mBC) by ICP-OES and the estimated boron concentrations (eBC) from the PET images were compared.ResultsThe percent difference between the mBC and eBC calculated based on the SUVmax was −5.2 ± 21.1% for the blood, −9.4 ± 22.3% for the brain, 1.6 ± 21.3% for the liver, −14.3 ± 16.8% for the spleen, −9.5 ± 27.5% for the pancreas, and 3.4 ± 43.2% for the tumor. Relatively large underestimation was observed for the lung (−48.4 ± 16.2%), small intestine (−37.8 ± 19.3%) and large intestine (−33.9 ± 11.0%), due to the partial volume effect arising from the air or feces contained in these organs. In contrast, relatively large overestimation was observed for the kidney (34.3 ± 29.3%), due to the influence of the high uptake in urine.ConclusionsThe absolute boron concentrations in tissues/tumors can be estimated from the SUVs on 18F-FBPA PET using a practical formula. Caution must be exercised in interpreting the estimated boron concentrations in the lung, small intestine and large intestine, to prevent the adverse effects of overexposure, which could occur due to underestimation by partial volume effect using PET.Electronic supplementary materialThe online version of this article (doi:10.1007/s12149-017-1172-5) contains supplementary material, which is available to authorized users.

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“…18 F-FMISO was prepared using the same method as previously mentioned ( 16 ). 18 F-HF was produced by an in-house cyclotron (HM-12S; Sumitomo Heavy Industry) and 18 F-FMISO was prepared with a UG-M1 synthesizer module using 3-(2-nitroimidazo-1-yl)-2-Otetrahydropyranyl-1-O-toluenesulfonyl-propanediol as a labeling precursor.…”

Section: Methodsmentioning

confidence: 99%

“…18 F-HF was produced by an in-house cyclotron (HM-12S; Sumitomo Heavy Industry) and 18 F-FMISO was prepared with a UG-M1 synthesizer module using 3-(2-nitroimidazo-1-yl)-2-Otetrahydropyranyl-1-O-toluenesulfonyl-propanediol as a labeling precursor. 18 F-FMISO PET-CT was subsequently performed ( 16 , 17 ).…”

Section: Methodsmentioning

confidence: 99%

In vivo evaluation of percutaneous carbon dioxide treatment for improving intratumoral hypoxia using 18F-fluoromisonidazole PET-CT

et al. 2021

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Quantitative evaluation of oxygen metabolism in the intratumoral hypoxia: 18F-fluoromisonidazole and 15O-labelled gases inhalation PET

Cited by 11 publications

References 31 publications

Voxel based comparison and texture analysis of 18F-FDG and 18F-FMISO PET of patients with head-and-neck cancer

Voxel based comparison and texture analysis of 18F-FDG and 18F-FMISO PET of patients with head-and-neck cancer

Practical calculation method to estimate the absolute boron concentration in tissues using 18F-FBPA PET

In vivo evaluation of percutaneous carbon dioxide treatment for improving intratumoral hypoxia using 18F-fluoromisonidazole PET-CT

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