Quantitative Evaluation of Post-stenotic Blood Flow Disturbance in Canine Femoral Artery Stenosis Model: An Early Experience With Vector Flow Imaging

Zhao, Rui; Zheng, Haining; Wang, Wei; Du, Yigang; Tong, Yisha; Wen, Chaoyang

doi:10.3389/fcvm.2022.829825

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…Plaque formation usually occurs in non-laminar regions ( 33 – 35 ). Tur values increase with the degree of blood flow disturbance and arterial stenosis ( 23 , 36 ). Low WSS or high oscillatory WSS affect the morphological structure and function of endothelial cells, as well as promote the formation of atherosclerosis ( 16 , 37 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

“…This could be the reason why the two parameters (WSS and Tur) are negatively correlated since both low WSS and non-laminar flow are related to atherosclerosis and plaque formation. A previous study ( 36 ) demonstrated that flows with Tur value < 1% can be considered laminar or nearly laminar flow. Another recent study ( 40 ) presented the Tur difference between common carotid artery and carotid bulb.…”

Section: Discussionmentioning

confidence: 99%

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Investigation on the differences of hemodynamics in normal common carotid, subclavian, and common femoral arteries using the vector flow technique

Song¹,

Liu²,

Dong³

et al. 2022

Front. Cardiovasc. Med.

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ObjectivesTo investigate the feasibility of the vector flow imaging (V Flow) technique to measure peripheral arterial hemodynamic parameters, including wall shear stress (WSS) and turbulence index (Tur) in healthy adults, and compare the results in different arteries.Materials and methodsFifty-two healthy adult volunteers were recruited in this study. The maximum and mean values of WSS, and the Tur values at early-systole, mid-systole, late-systole, and early diastole for total 156 normal peripheral arteries [common carotid arteries (CCA), subclavian arteries (SCA), and common femoral arteries (CFA)] were assessed using the V Flow technique.ResultsThe mean WSS values for CCA, SCA, and CFA were (1.66 ± 0.68) Pa, (0.62 ± 0.30) Pa, and (0.56 ± 0.27) Pa, respectively. The mean Tur values for CCA, SCA, and CFA were (0.46 ± 1.09%), (20.7 ± 9.06%), and (24.63 ± 17.66%), respectively. The CCA and SCA, as well as the CCA and CFA, showed statistically significant differences in the mean WSS and the mean Tur (P < 0.01). The mean Tur values had a negative correlation with the mean WSS; the correlation coefficient between log(Tur) and WSS is −0.69 (P < 0.05).ConclusionV Flow technique is a simple, practical, and feasible quantitative imaging approach for assessing WSS and Tur in peripheral arteries. It has the potential to be a useful tool for evaluating atherosclerotic plaques in peripheral arteries. The results provide a new quantitative foundation for future investigations into diverse arterial hemodynamic parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Investigation on the differences of hemodynamics in normal common carotid, subclavian, and common femoral arteries using the vector flow technique

Song¹,

Liu²,

Dong³

et al. 2022

Front. Cardiovasc. Med.

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“…Other biomarkers of relevance, such as turbulence, can be derived from vector flow imaging 46 , 47 . This turbulence will be most noticeable after the ligation and will cause substantial out-of-view flow.…”

Section: Discussionmentioning

confidence: 99%

Pulse wave and vector flow Imaging for atherosclerotic disease progression in hypercholesterolemic swine

Kemper

Karageorgos

Fodera

et al. 2023

Sci Rep

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Non-invasive monitoring of atherosclerosis remains challenging. Pulse Wave Imaging (PWI) is a non-invasive technique to measure the local stiffness at diastolic and end-systolic pressures and quantify the hemodynamics. The objective of this study is twofold, namely (1) to investigate the capability of (adaptive) PWI to assess progressive change in local stiffness and homogeneity of the carotid in a high-cholesterol swine model and (2) to assess the ability of PWI to monitor the change in hemodynamics and a corresponding change in stiffness. Nine (n=9) hypercholesterolemic swine were included in this study and followed for up to 9 months. A ligation in the left carotid was used to cause a hemodynamic disturbance. The carotids with detectable hemodynamic disturbance showed a reduction in wall shear stress immediately after ligation (2.12 ± 0.49 to 0.98 ± 0.47 Pa for 40–90% ligation (Group B) and 1.82 ± 0.25 to 0.49 ± 0.46 Pa for >90% ligation (Group C)). Histology revealed subsequent lesion formation after 8–9 months, and the type of lesion formation was dependent on the type of the induced ligation, with more complex plaques observed in the carotids with a more significant ligation (C: >90%). The compliance progression appears differed for groups B and C, with an increase in compliance to 2.09 ± 2.90×10−10 m2 Pa−1 for group C whereas the compliance of group B remained low at 8 months (0.95 ± 0.94×10−10 m2 Pa−1). In summary, PWI appeared capable of monitoring a change in wall shear stress and separating two distinct progression pathways resulting in distinct compliances.

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“…The canine femoral artery stenosis model creation has been described in our previous report. 19 Twelve beagle dogs aged 12-24 months were purchased from the Animal Experiment Centre of Nongnong (Beijing) Biotechnology Co. Ltd (Beijing, China). Preoperative duplex ultrasound scanning was performed to confirm that internal diameters of the canine femoral arteries were 3.0 ± 0.1 mm.…”

Section: Establishment Of Canine Femoral Artery Stenosis Modelmentioning

confidence: 99%

Phasicity and resistance of the arterial spectral Doppler waveform in a canine femoral focal artery stenosis model

et al. 2022

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Introduction: This study aims to evaluate changes in the arterial spectral Doppler waveform in a canine artery stenosis model. Methods: Canine femoral artery stenosis models were established in 12 beagle dogs. Doppler waveforms were recorded in the femoral artery preoperatively and postoperatively in the femoral artery and at the ankle after formation of a 50%, 70%, and 90% stenosis or occlusion. Major descriptors for arterial Doppler waveform were used to analyse waveforms. Results: The proportion of multiphasic waveforms proximal to a moderate stenosis decreased compared to normal baseline, although the difference was not statistically significant, whereas the decreases at the stenosis, distal to the stenosis, and at the ankle were significant ( p < 0.05). The decreases in arteries with a more severe stenosis or occlusion were significant at all locations ( p < 0.05). The proportion of high resistive waveforms decreased significantly at the ankle in the arteries with a moderate stenosis (50%) ( p = 0.002), but the decreases proximal to, at, and distal to the stenosis were not significant. The decreases were significant at all locations in the arteries with a more severe stenosis ( p < 0.05). The decrease was significant at the ankle in the arteries with an occlusion ( p < 0.001) but not significant pre, at, and post an occlusion. Conclusions: Phasicity and resistance of Doppler waveforms alter in canine femoral arteries with a stenosis. Phasicity change seems more sensitive in response to an arterial stenosis than resistance change. Additional information on arterial resistance could be obtained using end-diastolic ratios, resistive indices, and potentially end-systolic notch velocity measurements.

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Quantitative Evaluation of Post-stenotic Blood Flow Disturbance in Canine Femoral Artery Stenosis Model: An Early Experience With Vector Flow Imaging

Cited by 8 publications

References 32 publications

Investigation on the differences of hemodynamics in normal common carotid, subclavian, and common femoral arteries using the vector flow technique

Investigation on the differences of hemodynamics in normal common carotid, subclavian, and common femoral arteries using the vector flow technique

Pulse wave and vector flow Imaging for atherosclerotic disease progression in hypercholesterolemic swine

Phasicity and resistance of the arterial spectral Doppler waveform in a canine femoral focal artery stenosis model

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