Quantitative evaluation of subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus by three-dimensional echocardiography

Chen, Xiaoyan; Guo, Haifeng; Yang, Qingmei; Fang, Jianxiu; Kang, Xiaoyan

doi:10.1007/s10554-020-01833-5

Cited by 19 publications

(22 citation statements)

References 31 publications

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“…Type 2 diabetes mellitus (T2DM) accounts for more than 90% of diabetic patients (1). The incidence of cardiovascular disease is 2-3 times higher in T2DM patients compared to healthy individuals (2). Therefore, the evaluation of left ventricular systolic function in T2DM patients at an early stage is important for treatment and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Myocardial Work by Non-invasive Left Ventricular Pressure-Strain Loop in Patients With Type 2 Diabetes Mellitus

Huang

Cui

Zheng

et al. 2021

Front. Cardiovasc. Med.

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Background: Type 2 diabetes mellitus (T2DM) is a common risk factor for cardiovascular diseases. The aims of this study were to evaluate the changes in the left ventricular myocardial work in T2DM patients using the left ventricular pressure-strain loop (PSL) technique, and to explore the risk factors for the left ventricular myocardial work impairment.Methods: Fifty patients with T2DM and 50 normal controls (NCs) were included in the study. In addition to conventional echocardiography and two-dimensional speckle tracking echocardiography, the left ventricular myocardial work parameters were measured using PSL technology.Results: The absolute value for global longitudinal strain (GLS), global work index (GWI) and, global constructive work (GCW) were significantly decreased in the T2DM group (P < 0.05), while the left ventricular ejection fraction (LVEF) was not significantly different between the T2DM and NC groups. Multivariable linear regression analysis showed that hemoglobin A1c (HbA1c) was independently related to GWI (β = −0.452, P < 0.05), while HbA1c and the diabetes duration were independently related to GCW (β = −0.393, P < 0.05 and β = −0.298, P < 0.05, respectively).Conclusions: Changes in the left ventricular myocardial systolic function in T2DM patients were identified using PSL technology. HbA1c was shown to be an independent risk factor affecting GWI, while HbA1c and diabetes duration were demonstrated to be independent risk factors affecting GCW.

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Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Myocardial Work by Non-invasive Left Ventricular Pressure-Strain Loop in Patients With Type 2 Diabetes Mellitus

Huang

Cui

Zheng

et al. 2021

Front. Cardiovasc. Med.

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“…The results showed a strong correlation between early longitudinal systolic dysfunction measured by GLS and autonomic neuropathy of the myocardium 26 . Chen et al also highlighted the importance of 3D STE for the assessment of subclinical systolic dysfunction in type 2 DM patients with poor glycaemic control 25 …”

Section: Resultsmentioning

confidence: 93%

“…Subclinical systolic dysfunction was predominantly assessed using 2D STE parameters: GLS was measured in most of the cases, but global circumferential (GCS) and radial (GRS) strains were also measured in some of the included studies 4,7,8,16,21‐25 (Table 1). Furthermore, few studies also used 3D STE 1,7,26 and multiple‐layer strain 5,8,21,27‐30 for systolic function assessment.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, Lorenzo‐Almoros et al showed that intensive glycaemic control in humans (HbA1c < 7%) does not prevent cardiovascular complications in patients suffering from DM, 1 and several other studies found no association between HbA1c levels and systolic dysfunction 8,64 . However, many recent studies found that the biggest improvements in diastolic and systolic functions were seen in patients with the largest reduction in HbA1c levels 2,5,18,25,33,43,65 …”

Section: Resultsmentioning

confidence: 99%

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Assessment of subclinical diabetic cardiomyopathy by speckle‐tracking imaging

Minciună

Orășan

Minciună

et al. 2021

Eur J Clin Investigation

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Background Diastolic dysfunction is traditionally believed to be the first subclinical manifestation of diabetic cardiomyopathy (DCM), leading to systolic dysfunction and then overt heart failure. However, in the last few years, several studies suggested that systolic subclinical dysfunction measured by speckle‐tracking echocardiography (STE) may appear ahead of diastolic dysfunction. In this review, the main endpoint is to show whether subclinical myocardial systolic dysfunction appears ahead of diastolic dysfunction and the implication this may have on the evolution and management of DCM. Materials and methods We performed a search in PubMed for all relevant publications on the assessment of DCM by STE from 1 June 2015 to 1 June 2020. Results and Conclusions The results illustrate that subclinical systolic dysfunction assessed by STE is present in early DCM stages, with or without the association of diastolic dysfunction. This could be a promising perspective for the early management of patients with DCM leading to the prevention of the overt form of disease.

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“…In DM2, these patients may have related changes in cardiac function before the onset of clinical symptoms. The early changes of left ventricular function in patients with DM2 have been widely studied [2][3][4][5][6][7], and the evaluation of left atrial (LA) function has attracted more and more attention.…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study of Left Atrial Function and Left Atrial Stiffness in Type 2 Diabetic Patients with Normotensive Patients Without Symptomatic Cardiovascular Disease

Huang

Zhu

et al. 2021

Preprint

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Background: The purpose of this study was to investigate the relationship between left atrial function and left atrial stiffness in type 2 diabetic patients.Methods: A total of 41 healthy subjects (controls) and 39 patients with type 2 diabetes mellitus (DM2 patients) were enrolled in this study. The left atrial volume index was measured by biplanar Simpson method. The early and late diastolic velocities (e'and a') were measured by tissue Doppler in lateral and septal boeder of the mitral annulus. Lateral and septal myocardial velocities were averaged. E/eʹ ratio was computed.The peak atrial longitudinal strain (PALS) was analyzed by tow-dimensional speckle tracking imaging (2D-STI) technique.The ratio of E/e ' to PALS was used as an indicator of LASI.Results:The maximum volume (LAVImax), minimum volume (LAVImin) and pre-contraction volume (LAVIpre) of the left atrium in DM2 patients were significantly higher than those in the control groups, and the differences were statistically significant (P<0.05). The difference between PALS decrease and LASI increase was statistically significant (P<0.05).PALS and LASI were statistically correlated with three phase volume index of left atrial and E/e'ratio. LASI was superior to PALS and left atrial volume index in diagnosing diabetic normotensive patients without symptomatic cardiovascular disease.Conclusion: Compared with the controls, PALS decreased and LASI increased in DM2. PALS and LASI were significantly correlated with left atrial volume and E/e’. LASI showed the highest diagnostic efficacy in the diagnosis of diabetes. PALS and LASI can be used as indicators for early evaluation of left atrial function in patients with DM2.Trial registration number:+86-17856931224;date of registration:May 3,2021

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Quantitative evaluation of subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus by three-dimensional echocardiography

Cited by 19 publications

References 31 publications

Quantitative Analysis of Myocardial Work by Non-invasive Left Ventricular Pressure-Strain Loop in Patients With Type 2 Diabetes Mellitus

Quantitative Analysis of Myocardial Work by Non-invasive Left Ventricular Pressure-Strain Loop in Patients With Type 2 Diabetes Mellitus

Assessment of subclinical diabetic cardiomyopathy by speckle‐tracking imaging

A Preliminary Study of Left Atrial Function and Left Atrial Stiffness in Type 2 Diabetic Patients with Normotensive Patients Without Symptomatic Cardiovascular Disease

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