Quantitative evaluation of the enamel caries which were treated with casein phosphopeptide-amorphous calcium fluoride phosphate

Yazıcıoğlu, Önder; Yaman, Batu Can; Güler, Arif Yiğit; Koray, Fatma

doi:10.4103/1119-3077.180073

Cited by 12 publications

(19 citation statements)

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“…In this study, remineralization activity of the CPP‐ACFP group was found to be significantly higher in all time periods than the control group, which corroborates findings of previous studies (Hamba, Nikaido, Inoue, Sadr, & Tagami, ; Mehta et al, ; Yazicioğlu, Yaman, Güler, & Koray, ). This is because CPP‐ACFP exhibits superior remineralization properties to conventional fluoride varnishes (Ekambaram et al, ; Naveena, Nagarathana, & Sakunthala, ).…”

Section: Discussionsupporting

confidence: 92%

Analysis of efficacy of the self‐assembling peptide‐based remineralization agent on artificial enamel lesions

Üstün

Aktören

2019

Microscopy Res & Technique

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The objective of this in vitro study was to analyze and compare the biomimetic remineralizing efficacy of the self-assembling peptide (P11-4) with agents containing casein phoshopeptideamorhous calcium phosphate fluoride (CPP-ACFP) and sodium fluoride (NaF) on artificial caries lesions using DIAGNOdent and micro-computed tomography (μCT). Artificial enamel lesions were prepared on extracted impacted sound mandibular third molars. The samples were randomly allocated to four groups (n = 8): Group 1, P11-4 (Curodont Repair, Credentis AG, Switzerland); Group 2, CPP-ACFP (MI Varnish, GCCo., Japan); Group3, NaF (Duraphat Varnish, Colgate, Colgate-Palmolive, NY, USA); Group 4, artificial saliva (control). The agents were applied to demineralized surfaces according to manufacturers' instructions; all specimens were stored in artificial saliva for 1 month. Demineralization and remineralization on enamel surfaces were analyzed and quantified by DIAGNOdent (KaVo, Germany) and μCT (SkyScan1174, Belgium) for lesion depth/area/volume/mineral density (MD). The remineralization efficacy of the agents was evaluated by DIAGNOdent on 1st, 7th, 30th days and by μCT on 30th day. Data were statistically analyzed by ANOVA, Kruskal-Wallis, T test, and Wilxocon tests. The highest remineralization efficacy findings in all periods were determined in Group 1, followed by Groups 2, 3, and 4. The remineralization findings for fluorescence, MD, lesion depth in Group 1 were found significantly higher (p < 0.01) than Group 3; and no significant differences (p > 0.05) were found between Groups 1-2 and Groups 2-3. The area and volume change values in Groups 1, 2, and 3 have shown no significancy (p > 0.05). A significant correlation (p < 0.01) was found between μCT and DIAGNOdent methods. The data of this study have demonstrated that P11-4 has showed the best remineralization efficacy, followed by CPP-ACFP and NaF. It is concluded that self-assembling peptide-based remineralization agent can be used successfully for biomimetic remineralization of enamel subsurface lesions.

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Section: Discussionsupporting

confidence: 92%

Analysis of efficacy of the self‐assembling peptide‐based remineralization agent on artificial enamel lesions

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2019

Microscopy Res & Technique

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“…Dental caries is one of the major dental challenging problems maybe more prominent than other infectious diseases such as hypertension and heart infections. (1) It is easily detectable and reversible at an early stage. Once the incipient lesion proceeds to cavitation, the condition becomes irreversible.…”

Section: Introductionmentioning

confidence: 99%

“…(10) Diagnodent is a laser device measures uorescence, early demineralization with good to excellent sensitivity and improves the demonstrative precision of location of non-cavitated carious lesions. (1) This study will use Diagnodent to evaluate the impact of two remineralizing agents containing casein phosphopeptide amorphous calcium phosphate (CPP ACP), and Tricalcium phosphate (TCP) on white spot lesions.…”

Section: Introductionmentioning

confidence: 99%

Impact of Two Remineralizing Agents on White Spot Lesions

Alagha

2020

Preprint

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Aim of the study: This study evaluated the impact of two remineralizing agents containing casein phosphopeptideamorphous calcium phosphate (CPPACP), and Tricalcium phosphate (TCP) on white spot lesions. Materials and Methods: A total of ninety freshly extracted upper premolars were divided in three equal groups (30 each). Group A: Control group. Group B: Varnish containing CPP–ACP. Group C: Varnish containing TCP. The teeth were subjected to Diagnodent test after inducing white spot lesions to assess any surface changes present on the teeth. The readings were repeated post demineralization and post-remineralization. Results: Statistically significant difference was present in the mean values between the tested groups. CPP-ACP group recorded higher mean value at demineralization when compared to TCP group. Statistically significant difference (p < 0.0001) was present between the baseline and the demineralization values. CPP-ACP group presented higher remineralization results when compared to TCP group. T-test proved a significant difference between the tested groups. Conclusion: CPP-ACP containing varnish had higher remineralizing effect when compared to TCP containing varnish. Clinical Significance: Recently, the focus of restorative dentistry has been directed toward a conservative approach. Prevention and non-restorative treatment of initial enamel caries is the main concern. Remineralization procedures are the most preferred way of regeneration of lost tooth structure.

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“…These include dentifrices, chewing gums and topical pastes [10]. Bioactive agents based on milk proteincasein * email: murariu_alice@yahoo.com phosphopeptide (CPP) with amorphous calcium phosphate (ACP) have been also developed to release elements that enhance remineralization of the enamel and dentin [11]. CPP-ACP, a milk-derivative, comprises peptide fragments that are rich in phosphorylated seryl and glutamic acid residues that bind to amorphous calcium phosphate nanoparticles.…”

mentioning

confidence: 99%

“…These CPP-ACP nanoclusters are reported to adhere to enamel, plaque and pellicle, to inhibit bacterial adhesion to the tooth, and to act as a pH buffer against acid assault [10,12].When CPP ACP is combined with fluoride, the fluoride ions react with CPP ACP to form CPP amorphous calcium fluoride phosphate (ACFP). The CPP ACFPnanocomplex provides calcium, phosphate and fluoride ions to the surface of the teeth and therefore has an important effect on enamel remineralization [11].…”

mentioning

confidence: 99%

Comparative Evaluation of Casein Phosphopeptide - Amorphous Calcium Phosphate and Fluoride in Managing Early Caries Lesions

Bobu¹,

Murariu²,

Topor³

et al. 2019

Rev. Chim.

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The aim of the present study was to assess the remineralizing potential of 10% casein phosphopeptide-amorphous calcium phosphate complex (CPP-ACP) -Recaldent used alone or with fluoride (CPP-ACFP) as compared to fluoride mouthrinse for the non-invasive treatment of occlusal non-cavitary caries lesions in vivo.A total of eighty subjects were randomly assigned to four groups, i.e. group 1 - 10% CPP-ACP, group 2- 10% CPP-ACP + 0.2% NaF, group 3- 0.05% NaF mouthrinse and group 4 �control. The lesions were assessed using visual examination and DIAGNOdent measurements. After 12 weeks of using the corresponding product, the results showed that the highest decrease in fluorescence was produced by CPP-ACFP (from 16.28�1.40 to 6.53�0.59, p=0.002), followed by CPP-ACP (from 15.70�1.82 to 8.18�0.70, p=0.004) and fluoride mouthrinse (from 14.32�1.72 to 7.88�0.68, p=0.005), significantly higher than in the control group (p[0.05). No significant differences were found between the three treatment groups.

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Quantitative evaluation of the enamel caries which were treated with casein phosphopeptide-amorphous calcium fluoride phosphate

Abstract: CPP-ACFP can be used in the treatment of white spot lesions.

Cited by 12 publications

References 0 publications

Analysis of efficacy of the self‐assembling peptide‐based remineralization agent on artificial enamel lesions

Analysis of efficacy of the self‐assembling peptide‐based remineralization agent on artificial enamel lesions

Impact of Two Remineralizing Agents on White Spot Lesions

Comparative Evaluation of Casein Phosphopeptide - Amorphous Calcium Phosphate and Fluoride in Managing Early Caries Lesions

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