Quantitative Functional Group Determination In The Identification of Organic Compounds

Siggia, Sidney.

doi:10.1021/ac60052a036

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…CHEMICAL PROCEDURES Quantitative aspects of functional group determination in characterization of organic compounds have been discussed by Siggia (75). Determination of functional equivalent weight by functional group analysis, verification of suspected identity, and other applications are considered.…”

Section: Physical Propertiesmentioning

confidence: 99%

Characterization of Organic Compounds

Peck¹

1952

Anal. Chem.

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HE accepted requirements for full characterization of an T organic compound include establishment of purity of sample, determination, of physical properties, determination of elementary composition, functional groups, and empirical formula, and elucidation of structural formula and spatial relationships. It is evident that identification of a known molecule will involve less extensive investigation than full characterization of a complex new compound. The characterization of simple or complex compounds may be accomplished by any of a Tide variety of techniques and methods, some of which are more effective than others. The choice of criteria and procedural steps is often dependent on availability of special equipment. Infrared absorption spectra and x-ray diffraction patterns alone, for example, are sufficient to identify many known substances; identification carried out by chemical methods, while sometimes more timeconsuming, is equally effective.A consequence of the recent increase in number and scope of chemical studies of naturally occurring organic substances is seen in the widely held view that thorough training in principles of characterization is of fundamental importance for students majoring in organic chemistry. A comprehensive treatise on detailed methods and techniques of characterization may some day be available. I t is probably true, however, that after successfully completing the characterization of a complex, new organic molecule the chemist enjoys a thrill of satisfaction derived in large part from the realization that the sequence of steps used was not given to him in a single reference work but was the result of his own experience, insight, and skill (and perhaps some luck).The present review of recent contributions in this realm of characterization is concerned with methods for determining purity of samples, procedures for establishing physical properties, and chemical methods of characterization. PURITYIt is essential for clear-cut determination of properties and for interpretable degradative work that the samples employed be substantially pure. Procedures which are now found most useful for establishment of degree of purity of samples were reviewed recently (64, 65). No fundamentally new methods of these types have been introduced during the past year, but there have appeared a number of papers in which extensions or new applications of method are described.The development by Craig (16, 64) of a machine for carrying out many-plate countercurrent distributions, and the recent introduction of a convenient glass apparatus for larger numbers of separation stages (19, 65) are now widely recognized. These methods have been introduced in many laboratories and have proved their worth. Continued studies by Craig and his coworkers have culminated in the development of an automatic control device for use with the glass apparatus (17). A strictly discontinuous extraction train containing 220 glass equilibration cells may now be operated automatically, so that 800 equilibration stages (about 150,000 ext...

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Section: Physical Propertiesmentioning

confidence: 99%

Characterization of Organic Compounds

Peck¹

1952

Anal. Chem.

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“…Quant itative methods for functional groups are usually much quicker and less tedious than organic elemental JAMES S. FRITZ Iowa State College, Ames, Iowa analysis procedures. Advantages of this approach to quantitative organic analysis have been pointed out in a convincing manner by Siggia [1,2).…”

mentioning

confidence: 93%

Organic quantitative analysis

Fritz¹

1954

J. Chem. Educ.

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Quantitative Functional Group Determination In The Identification of Organic Compounds

Cited by 2 publications

References 13 publications

Characterization of Organic Compounds

Characterization of Organic Compounds

Organic quantitative analysis

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