Quantitative gated single photon emission computed tomography imaging: A counts-based method for display and measurement of regional and global ventricular systolic function

Smith, William H.; Kastner, Robert J.; Calnon, Dennis A.; Segalla, Dana; Beller, George A.; Watson, Denny D.

doi:10.1016/s1071-3581(97)90002-7

Cited by 82 publications

(23 citation statements)

References 13 publications

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“…Furthermore, comparative studies with ERNA and magnetic resonance imaging have confirmed the reliability of 4D-MSPECT (University of Michigan Medical Center, Ann Arbor, MI) [32,34,55,56]. Other quantitative algorithms that have achieved commercial diffusion are the MultiDim (Stanford University, Palo Alto, CA), the W-L CQ (Yale University, New Haven, CT), the Left Ventricular Global Thickening Fraction (LVGTF) and the Perfusion and Functional Analysis for Gated SPECT (pFAST, Sapporo Medical University, Sapporo, Japan) [57][58][59][60].…”

Section: Value Of Gated Spect For Estimating Left Ventricular Functionmentioning

confidence: 99%

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

Sciagrà

2007

Eur J Nucl Med Mol Imaging

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Background Gating of single-photon emission computed tomography (SPECT) has significantly improved the reliability and diagnostic accuracy of myocardial perfusion imaging. The functional parameters derived from this technique, mainly left ventricular volumes and ejection fraction, have been demonstrated to be accurate and reproducible. They are able to increase the detection of severe and extensive coronary artery disease and show a significant incremental prognostic power over perfusion abnormalities. Therefore, the importance given to gated SPECT functional data has progressively grown. Discussion This circumstance has further expanded the indications for myocardial perfusion imaging and strengthened its position among the different imaging modalities. Moreover, several studies show that the evaluation of ventricular function may have a leading part in justifying the execution of perfusion scintigraphy in various clinical conditions. Aim Aim of this review is to describe this evolution of gated SPECT functional assessment from a supporting rank with respect to perfusion, to a main actor position in the field of cardiac imaging.

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Section: Value Of Gated Spect For Estimating Left Ventricular Functionmentioning

confidence: 99%

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

Sciagrà

2007

Eur J Nucl Med Mol Imaging

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“…3). Normally contracting myocardium artefactually ''concentrates'' the counts by at least 20% [11,12]; therefore a normally contracting segment undergoes at least 2 colour changes per cardiac cycle. A score of 2 indicated normal thickening ([2 colour changes), 1 indicated reduced thickening (1-2 colour changes) and 0 (\1 colour change) indicated absence of thickening.…”

Section: Visual Wall Thickening Assessmentmentioning

confidence: 99%

Myocardial wall motion and thickening assessment in early gated SPECT images of acute coronary syndrome patients likely to have inferolateral perfusion defects

Neill

Harbinson

Adgey

2010

Int J Cardiovasc Imaging

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The purpose of this study was to compare semi-quantitative visual scores of perfusion, motion and thickening with an automated hypoperfusion index (HI) in patients with suspected acute inferolateral perfusion defects. In the absence of perfusion defects motion and thickening abnormalities were assessed. Sixty-eight patients with chest pain at rest and either ST depression ≥0.1 mV in ≥1 of leads I, aVL, V1-V6 on 12-lead ECG or ST elevation ≥0.05 mV in ≥1 posterior lead on the body surface map comprised the study population. A rest gated perfusion scan was performed within 24 h of symptoms. Scans were scored for perfusion, motion and thickening semi-quantitatively. The scores were compared to the automated HI. A 12 h Troponin T >0.09 ng/ml indicated myocardial infarction (MI). Sixty-five patients (96%, 65/68) had MI. The summed perfusion score correlated well with the HI (ρ = 0.90, P < 0.01) and agreement between scorers was good (κ = 0.77, 95% CI = 0.57-0.94). The summed motion score correlated with the HI (ρ = -0.61, P < 0.01) and agreement between scorers was moderate (κ = 0.65, 95% CI = 0.52-0.79). Summed thickening score correlated with HI (ρ = -0.67, P < 0.01) and agreement between scorers was good (κ = 0.74, 95% CI = 0.64-0.88). Of the 1156 segments assessed (68 × 17), 542 had normal perfusion. Of these normally perfused segments, 113 (21%, 113/542) had a motion abnormality and 102 (19%, 102/542) had a thickening abnormality. Three patients with proven myocardial infarction had normal myocardial perfusion (HI ≤ 5) but exhibited wall motion and thickening abnormalities. In conclusion, assessment of wall motion and thickening in addition to perfusion in acute myocardial perfusion imaging may improve the diagnostic sensitivity for acute MI. Of the scores addressing motion and thickening, interobserver agreement was better for the summed thickening score.

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“…A linear correlation between the regional count and wall thickness has been demonstrated by a phantom study in which the object size was 2-fold smaller than the spatial resolution (FWHM) of the SPECT image. 18 As to the frame number, we performed 12-frame gating in this study because it has been reported that the EF calculated by 8-frame gating is smaller than 16-frame gating, and 16-frame gating requires more counts.…”

Section: Relationship Between the Peak Contraction Phase (Sdp) And Thmentioning

confidence: 99%

Relationship Between Asynchronous Myocardial Contraction and Left Ventricular Systolic and Diastolic Function-Assessment Using the ECG-Gated Polar Map With 99mTc-Methoxy-Isobutyl Isonitrile-

Sugihara

Yonekura

Matsumoto

et al. 2005

Circ J

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synchronous myocardial contraction occurs with myocardial disorders such as dilated cardiomyopathy, 1 left bundle-branch block 2 and ischemic heart disease, 3 and is believed to decrease both systolic and diastolic cardiac function. However, there are few methods of quantitating the 3-dimensional (D) asynchronous myocardial contraction and the relationship between asynchrony and cardiac function has not been clarified quantitatively.Left ventricular (LV) function has been evaluated clinically by echocardiography 4 and by ECG-gated blood pool study, 5 and novel echocardiographic methods 6-8 such as tissue Doppler imaging and ECG-gated single-photon emission computed tomography (SPECT) 9 have been developed. In particular, quantitative gated SPECT software (QGS; Cedars-Sinai Medical Center, Los Angeles, CA, USA) enables evaluation of LV function by accurately determining the inner edge of the left ventricle. 10,11 However, we cannot use these methods to quantitate the 3-D heterogeneity of myocardial contraction, because the motion of the Circulation Journal Vol. 69, February 2005 inner edge of the ventricle does not always concord with the regional wall thickening.To evaluate asynchrony of regional myocardial contraction, we used 99m Tc-methoxy-isobutyl isonitrile (MIBI) to construct an ECG-gated polar map and regional contraction curve based on the fact that the ventricular wall thickness correlated with the regional myocardial count. We then compared the results of QGS software and Doppler echocardiography in a patient with an old myocardial infarction (OMI) to test the hypothesis that asynchrony decreased cardiac function by disturbing the harmonic contraction and relaxation of the myocardium. Methods Patient PopulationThe study group comprised 12 normal subjects (11 males, one female, aged 64±10 years) and 38 patients with an OMI (ie, ≥3 months after onset; 34 males, 4 females, aged 67±9). Patients with arrhythmias, valvular heart disease, small ventricle (end-diastolic volume <50 ml) and myocardial hypertrophy were excluded, as were patients with a complete perfusion defect. Data Acquisition and AnalysisAfter injection of 1,000 MBq of 99m Tc-MIBI, ECG-gated SPECT was performed using an L-shaped dual detector gamma camera (Optima NX; GE Medical Systems, Background To quantitate the degree of 3-dimensional asynchronous myocardial contraction, an ECG-gated polar map method was developed with 99m Tc-methoxy-isobutyl isonitrile, and used to investigate the relationship between asynchrony and left ventricular (LV) function. Methods and ResultsTwelve normal subjects and 38 patients with an old myocardial infarction were studied with ECG-gated single-photon emission computed tomography (SPECT). In each frame, a myocardial perfusion polar map was reconstructed and the peak contraction phase in each pixel was displayed (phase map). The degree of asynchronous contraction was assessed from the standard deviations of the peak contraction phase (SDP) on the phase map. Ejection fraction (EF), peak ejection rate (PER), 1/...

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Quantitative gated single photon emission computed tomography imaging: A counts-based method for display and measurement of regional and global ventricular systolic function

Abstract: This method requires no edge detection or geometric boundary estimates. Computer results are presented in a simple and intuitive format, which is uniform for parameters of both perfusion and function. The method is robust and produces relatively few false-positive results.

Cited by 82 publications

References 13 publications

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene

Myocardial wall motion and thickening assessment in early gated SPECT images of acute coronary syndrome patients likely to have inferolateral perfusion defects

Relationship Between Asynchronous Myocardial Contraction and Left Ventricular Systolic and Diastolic Function-Assessment Using the ECG-Gated Polar Map With 99mTc-Methoxy-Isobutyl Isonitrile-

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