Quantitative gene expression of TGF-β1, TNF-α, IL-1β, and IL-6 in the renal artery wall of chronically rejected human renal allografts

Żegarska, Jolanta; Pączek, Leszek; Pawłowska, Monika; Podrzucki, Wawrzyniec; Rowińskí, W; Malanowski, P.; Wszoła, Michał; Mróz, Andrzej

doi:10.1016/s0041-1345(02)03608-4

Cited by 12 publications

(9 citation statements)

References 11 publications

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“…In human kidney transplantation several reports have also linked the gene expression of various cytokines with transplant events such as acute and chronic rejection [14,15]. Similar to RCC, these links were made using single gene strategies such as rt-PCR, yet the majority of these cytokines were not observed in any of the transplant samples via microarray.…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of kidney microarray datasets: investigation of cytokine gene detection and correlation with rt-PCR and detection thresholds

Park

Stegall

2007

BMC Genomics

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Background: Microarrays provide a means to simultaneously examine the gene expression of the entire transcriptome in a single sample. Many studies have highlighted the need for novel software and statistical approaches to assess the measured gene expression. Less attention has been directed toward whether genes considered undetectable by microarray can be detected by other strategies or whether these genes can provide accurate gene expression determinations. In the kidney this is a concern for genes such as cytokines which dramatically influence the immune response but are often considered low abundance genes produced by a small number of cells.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of kidney microarray datasets: investigation of cytokine gene detection and correlation with rt-PCR and detection thresholds

Park

Stegall

2007

BMC Genomics

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“…RT‐PCR was performed using the TaqMan Universal PCR Master Mix reagent (Applied Biosystems) 16, 17. The values in all the samples were normalized to the expression level of the endogenous control, GAPDH 16, 18…”

Section: Methodsmentioning

confidence: 99%

Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis # †

et al. 2009

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The specific mechanisms of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) pathogenesis remain unknown. In the present study we investigated the differences between NAFL and NASH in terms of liver lipid metabolites and serum lipoprotein. In all, 104 Japanese subjects (50 men and 54 postmenopausal women) with histologically verified NAFL disease (NAFLD) (51 with NAFL, 53 with NASH) were evaluated; all diagnoses were based on liver biopsy findings and the proposed diagnostic criteria. To investigate the differences between NAFL and NASH in humans, we carefully examined (1)

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“…All TaqMan RT–PCR data were obtained and processed using Sequence Detection Software version 1.6.3 (Applied Biosystems). The values in all the samples were normalised to the expression level of the endogenous control, GAPDH 16 18…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease

Fujita

Nozaki

Wada

et al. 2008

Gut

107

101

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Quantitative gene expression of TGF-β1, TNF-α, IL-1β, and IL-6 in the renal artery wall of chronically rejected human renal allografts

Cited by 12 publications

References 11 publications

A meta-analysis of kidney microarray datasets: investigation of cytokine gene detection and correlation with rt-PCR and detection thresholds

A meta-analysis of kidney microarray datasets: investigation of cytokine gene detection and correlation with rt-PCR and detection thresholds

Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis # †

Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease

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