Quantitative hippocampal MRI and intractable temporal lobe epilepsy

Abstract

Quantitative MRI combining HCT2 and HCVR is a reliable method for diagnosing hippocampal sclerosis noninvasively. End-folium sclerosis and amygdala sclerosis should be considered in patients with intractable TLE and negative findings on MRI studies, including quantitative measures of the hippocampus.

Multimodal MRI Evaluation in Intractable Epilepsy with Pathologically Confirmed Mesial Temporal Sclerosis

“…Jackson et al originally reported that T2 relaxometry maps were abnormal in all patients with MTS (18). However other groups have reported relatively lesser sensitivity (19), in our study the sensitivity of T2 relaxometry to identify the affected side is only 85 % similar to other study. Majority of the patients who had loss of volume also had longer T2 relaxation.…”

Mesial Temporal Sclerosis: Accuracy of NeuroQuant versus Neuroradiologist

“…17,18 The anatomy of the hippocampus is quite intricate, with curved surfaces and layers of gray and white matter that render parcellation of the cortex from subcortical content a difficult task. The plane of orientation also does not lend itself to easy assessment in the axial plane: This is the plane in which neuroradiologists are often most comfortable.…”

MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders

“…These methods have demonstrated considerable efficacy, especially with the addition of T2 relaxation time data. [36][37][38][39][40][41] Patients with mesial temporal lobe epilepsy exhibit smaller hippocampal volumes. 16,[42][43][44][45][46][47] This hippocampal volume reduction is highly concordant with the side of the epileptogenic focus, and hippocampal deficits are most pronounced ipsilateral to the epileptic focus.…”