Quantitative in vivo assessment of human mitral valve coaptation area after undersized ring annuloplasty repair for ischemic mitral regurgitation

Simonian, Natalie T.; Líu, Hao; Pouch, Alison M.; Gorman, Joseph H.; Gorman, Robert C.; Sacks, Michael S.

doi:10.1016/j.xjtc.2022.09.013

Cited by 7 publications

(2 citation statements)

References 40 publications

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“…Understandably, this has not been reported before as histological analyses of microstructure in DMVD offer only a lateral view, which is limited in terms of biomechanical analysis. This finding is particularly important in the novel in silico studies investigating mitral regurgitation, 41 – 43 , as a quantified analysis of the microstructure in DMVD is a necessity. In addition, the current study will enable a more accurate mechanical modeling of the MVL 5 .…”

Section: Discussionmentioning

confidence: 94%

Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications

Sadeghinia,

Persson,

Ellensen

et al. 2024

Sci Rep

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Degenerative mitral valve disease is a common valvular disease with two arguably distinct phenotypes: fibroelastic deficiency and Barlow’s disease. These phenotypes significantly alter the microstructures of the leaflets, particularly the collagen fibers, which are the main mechanical load carriers. The predominant method of investigation is histological sections. However, the sections are cut transmurally and provide a lateral view of the microstructure of the leaflet, while the mechanics and function are determined by the planar arrangement of the collagen fibers. This study, for the first time, quantitatively examined planar collagen distribution quantitatively in health and disease using second harmonic generation microscopy throughout the thickness of the mitral valve leaflets. Twenty diseased samples from eighteen patients and six control samples were included in this study. Healthy tissue had highly aligned collagen fibers. In fibroelastic deficiency they are less aligned and in Barlow’s disease they are completely dispersed. In both diseases, collagen fibers have two preferred orientations, which, in contrast to the almost constant one orientation in healthy tissues, also vary across the thickness. The results indicate altered in vivo mechanical stresses and strains on the mitral valve leaflets as a result of disease-related collagen remodeling, which in turn triggers further remodeling.

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Section: Discussionmentioning

confidence: 94%

Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications

Sadeghinia,

Persson,

Ellensen

et al. 2024

Sci Rep

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show abstract

“…Noninvasive measurement of the leaflet strain is now possible to explore its role in the MV-LV coaptation dynamic [94,95]. Several groups are actively exploring how these mechanical leaflet changes compound tethering to augment MR and its associated heart failure and mortality [96][97][98][99][100].…”

Section: Annular Mechanics and Remodelingmentioning

confidence: 99%

Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

et al. 2023

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The geometrical details and biomechanical relationships of the mitral valve–left ventricular apparatus are very complex and have posed as an area of research interest for decades. These characteristics play a major role in identifying and perfecting the optimal approaches to treat diseases of this system when the restoration of biomechanical and mechano-biological conditions becomes the main target. Over the years, engineering approaches have helped to revolutionize the field in this regard. Furthermore, advanced modelling modalities have contributed greatly to the development of novel devices and less invasive strategies. This article provides an overview and narrative of the evolution of mitral valve therapy with special focus on two diseases frequently encountered by cardiac surgeons and interventional cardiologists: ischemic and degenerative mitral regurgitation.

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A Computational Pipeline for Patient-Specific Prediction of the Post-operative Mitral Valve Functional State

Líu

Simonian

Pouch

et al. 2023

Lecture Notes in Computer Science

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Quantitative in vivo assessment of human mitral valve coaptation area after undersized ring annuloplasty repair for ischemic mitral regurgitation

Cited by 7 publications

References 40 publications

Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications

Quantified planar collagen distribution in healthy and degenerative mitral valve: biomechanical and clinical implications

Utilization of Engineering Advances for Detailed Biomechanical Characterization of the Mitral–Ventricular Relationship to Optimize Repair Strategies: A Comprehensive Review

A Computational Pipeline for Patient-Specific Prediction of the Post-operative Mitral Valve Functional State

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