Quantitative investigations on thermal response of adipose tissue to focused ultrasonic energy

Abstract

Thermal responses of adipose tissue to high intensity focused ultrasound (HIFU) were quantitatively evaluated for effective clinical lipolysis. A single-element HIFU transducer (4 MHz and 4.5 mm focal depth) was used in a linear motion to thermally treat the tissue at various acoustic energy densities and treatment gaps. Both interstitial temperature rise and denatured lesions increased with the energy density (up to 21.1 ± 1.9 K and 0.40 ± 0.15 mm2). No thermal overlapping was observed due to selective application of the ultrasonic beams. The optimization of noninvasive HIFU treatment parameters may ensure clinical outcomes of HIFU-assisted lipolysis in terms of efficacy and safety.

Effect of dissolved oxygen level of water on ultrasonic power measured using calorimetry

“…Recently, concern has been growing regarding the safety of ultrasonic therapeutic equipment such as high-intensity focused ultrasound (HIFU) [1][2][3][4][5][6][7] devices, which expose the human body to high-power ultrasound. The HIFU devices used in clinical practice destroy cancer cells via the thermal effect of high-power ultrasound.…”