“…Beside epithelial secretion products (i.e., mucins and trefoil factor family [TFF] peptides), 11,12 a decisive role is played by capillary attraction [13][14][15][16][17][18][19] aided by contraction of the lacrimal part of the orbicularis muscle with blinking 3,16,20 -23 and distension of the sac, as well as a passive wringing out of the sac because of its medial attachment and helically arranged fibrillar structures. 3 The results of the present study suggest that the cavernous body of the lacrimal passage acts as a further mechanism in tear outflow, is under neuronal control by involvement in a complex neuronal reflex feedback mechanism, and can be influenced pharmacologically.…”