Quantitative magnetic resonance imaging for evaluating of the cerebrospinal fluid kinetics with 17O-labeled water tracer: A preliminary report

Sugimori, Hiroyuki; Kameda, Hiroyuki; Harada, Taisuke; Ishizaka, Kinya; Kajiyama, Masayoshi; Kimura, T.; Udo, Niki; Matsushima, Masaaki; Nagai, Ayako; Wakita, Masahiro; Kusumi, Ichiro; Yabe, Ichiro; Kudo, Kohsuke

doi:10.1016/j.mri.2021.12.005

Cited by 6 publications

(15 citation statements)

References 19 publications

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“…Systemic administration of 20% 17 O-labeled water at a dose of 1 mL/kg caused no side effects in 14 participants in one study (3). Intrathecal administration of 10 mL of 10% 17 O-labeled water caused no adverse effects in four patients in another study (8). 17 O-labeled water is a safe but expensive tracer (several hundred US dollars per mL), and the routine use of large amounts of this tracer is not practical.…”

Section: Discussionmentioning

confidence: 99%

“…The formula to convert the signal intensity to of 17 O concentration has been reported (8). The concentration of 17 O-labeled water can be estimated from the echo time (in s), signal intensity before and after administration, natural abundance ratio of 17 O (0.038%), and R 2 of 17 O 3.33 s −1 .…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Given that 17 O-labeled water is a water molecule, it can be safely administered without inducing an allergic reaction in living organisms or risk in patients with renal failure. The safety of intravenous and intrathecal administration of 17 O-labeled water has been reported in humans (3,8). 15 O-positron emission tomography (PET) is considered to be the gold standard for the quantitative analysis of cerebral blood flow and oxygen metabolism.…”

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confidence: 99%

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17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function

Yoshida

Naganawa²,

Kobayashi³

et al. 2022

Front. Neurol.

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We evaluated the inner ear distribution of 17O-labeled saline administered to the human tympanic cavity. Magnetic resonance imaging was performed after intratympanic administration in five healthy volunteers and one patient with cochlear endolymphatic hydrops. In all volunteers, 17O-labeled water permeated the cochlear basal turn and vestibule at 30 min and disappeared gradually within 2–4 h. All participants experienced positional vertigo lasting a few hours to a few days. Visualization of 17O-labeled water distribution in the endolymphatic space of the posterior ampulla showed indistinct separation of endolymph and perilymph in the cochlea and most of the vestibule in all participants. Intralabyrinthine distribution of 17O-labeled water differed from that in previous reports of intratympanically administered gadolinium-based contrast agent. 17O-labeled water in the endolymphatic space may cause heavier endolymph and positional vertigo. These results of this study may add new insights for investigating the distribution and the effects of molecules in the inner ear after the intratympanic administration in living humans.

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function

Yoshida

Naganawa²,

Kobayashi³

et al. 2022

Front. Neurol.

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“…Intrathecal administration requires a lower dose as 10 mL and is more practical than IV administration, which can require more than 100 mL for a single dose. 50 Recently, there have been reports of CSF and GBCA being absorbed from the choroid plexus. 51,52 The absorption of IT-GBCA from the choroid plexus was reported to be delayed in patients with iNPH compared with controls.…”

Section: Mri With the Administration Of Exogenous Contrast Agentsmentioning

confidence: 99%

The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging

Naganawa¹,

Taoka

Ito

et al. 2023

Invest Radiol

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The concept of the glymphatic system was proposed more than a decade ago as a mechanism for interstitial fluid flow and waste removal in the central nervous system. The function of the glymphatic system has been shown to be particularly activated during sleep. Dysfunction of the glymphatic system has been implicated in several neurodegenerative diseases. Noninvasive in vivo imaging of the glymphatic system is expected to be useful in elucidating the pathophysiology of these diseases. Currently, magnetic resonance imaging is the most commonly used technique to evaluate the glymphatic system in humans, and a large number of studies have been reported. This review provides a comprehensive overview of investigations of the human glymphatic system function using magnetic resonance imaging. The studies can be divided into 3 categories, including imaging without gadolinium-based contrast agents (GBCAs), imaging with intrathecal administration of GBCAs, and imaging with intravenous administration of GBCAs. The purpose of these studies has been to examine not only the interstitial fluid movement in the brain parenchyma, but also the fluid dynamics in the perivascular and subarachnoid spaces, as well as the parasagittal dura and meningeal lymphatics. Recent research has even extended to include the glymphatic system of the eye and the inner ear. This review serves as an important update and a useful guide for future research directions.

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Oxygen extraction fraction (OEF) values and applications in neurological diseases

Engle,

Saberi,

Bain

et al. 2024

Neurol Sci

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Quantitative magnetic resonance imaging for evaluating of the cerebrospinal fluid kinetics with 17O-labeled water tracer: A preliminary report

Cited by 6 publications

References 19 publications

17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function

17O-labeled water distribution in the human inner ear: Insights into lymphatic dynamics and vestibular function

The Glymphatic System in Humans: Investigations With Magnetic Resonance Imaging

Oxygen extraction fraction (OEF) values and applications in neurological diseases

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