Quantitative magnetization transfer imaging for non‐contrast enhanced detection of myocardial fibrosis

López, Karina; Neji, Radhouène; Bustin, Aurélien; Rashid, Imran; Hajhosseiny, Reza; Malik, Shaihan J.; Teixeira, Rui Pedro A. G.; Razavi, Reza; Prieto, Claudia; Roujol, Sébastien; Botnar, René M.

doi:10.1002/mrm.28577

Cited by 1 publication

(2 citation statements)

References 44 publications

(71 reference statements)

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“…This requires imaging sequences with ultrashort echo times (33). Additionally, magnetization transfer techniques aim at assessing macromolecular changes associated with some types of myocardial fibrosis (47). It remains unclear whether these non-contrast-based approaches that detect hydrogen nuclei tied to connective tissue render it feasible to quantify diffuse interstitial fibrosis.…”

Section: Cardiac Mri (Cmr)mentioning

confidence: 99%

“…It remains unclear whether these non-contrast-based approaches that detect hydrogen nuclei tied to connective tissue render it feasible to quantify diffuse interstitial fibrosis. Furthermore, these biomarkers not only may reflect changes in connective tissue content but also are presumably affected by necrosis and the associated loss of mitochondrial protein content or an increase in water mobility within myocardial scar tissue (47). Combining different endogenous contrast mechanisms and weightings may nevertheless allow for identifying a fingerprint for myocardial fibrosis.…”

Section: Cardiac Mri (Cmr)mentioning

confidence: 99%

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Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy

Bengel,

Diekmann,

Hess

et al. 2023

J Nucl Med

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Myocardial fibrosis is a major contributor to the development and progression of heart failure. Significant progress in the understanding of its pathobiology has led to the introduction and preclinical testing of multiple highly specific antifibrotic therapies. Because the mechanisms of fibrosis are highly dynamic, and because the involved cell populations are heterogeneous and plastic, there is increasing emphasis that any therapy directed specifically against myocardial fibrosis will require personalization and guidance by equally specific diagnostic testing for successful clinical translation. Noninvasive imaging techniques have undergone significant progress and provide increasingly specific information about the quantity, quality, and activity of myocardial fibrosis. Cardiac MRI can precisely map the extracellular space of the myocardium, whereas nuclear imaging characterizes activated fibroblasts and immune cells as the cellular components contributing to fibrosis. Existing techniques may be used in complementarity to provide the imaging biomarkers needed for the success of novel targeted therapies. This review provides a road map on how progress in basic fibrosis research, antifibrotic drug development, and high-end noninvasive imaging may come together to facilitate the success of fibrosis-directed cardiovascular medicine.

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Section: Cardiac Mri (Cmr)mentioning

confidence: 99%

Section: Cardiac Mri (Cmr)mentioning

confidence: 99%

Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy

Bengel,

Diekmann,

Hess

et al. 2023

J Nucl Med

View full text Add to dashboard Cite

show abstract

Quantitative magnetization transfer imaging for non‐contrast enhanced detection of myocardial fibrosis

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 1 publication

References 44 publications

Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy

Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy

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