Quantitative Measurement of Oxygen Extraction Fraction (OEF) Using Respiratory Modulated Perfusion MRI

Oghabian, Zeinab; Jafari, Amir

doi:10.5812/iranjradiol.64253

Cited by 2 publications

(1 citation statement)

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“…Though CBF is lower in white matter relative to gray matter (Leenders et al, 1990), RBC velocity and flux are actually higher in the white matter, likely because there is a reduced number of vessels that must pass a great volume of blood (Li et al, 2019b). As would be predicted with greater flux and shorter transit times, there evidence that the efficiency of oxygen extraction may also be reduced in white matter (Leenders et al, 1990;Hyder et al, 2016;Oghabian and Jafari, 2018). Aside from features that affect blood flow and nutrient abundance, there are differences in the BBB composition between gray and white matter, too.…”

Section: Regional Heterogeneity In the Cerebral Vasculaturementioning

confidence: 98%

Susceptibility to capillary plugging can predict brain region specific vessel loss with aging

Schager

Brown

2020

J Cereb Blood Flow Metab

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Vessel loss in the aging brain is commonly reported, yet important questions remain concerning whether there are regional vulnerabilities and what mechanisms could account for these regional differences, if they exist. Here we imaged and quantified vessel length, tortuosity and width in 15 brain regions in young adult and aged mice. Our data indicate that vessel loss was most pronounced in white matter followed by cortical, then subcortical grey matter regions, while some regions (visual cortex, amygdala, thalamus) showed no decline with aging. Regions supplied by the anterior cerebral artery were more vulnerable to loss than those supplied by middle or posterior cerebral arteries. Vessel width and tortuosity generally increased with age but neither reliably predicted regional vessel loss. Since capillaries are naturally prone to plugging and prolonged obstructions often lead to vessel pruning, we hypothesized that regional susceptibilities to plugging could help predict vessel loss. By mapping the distribution of microsphere-induced capillary obstructions, we discovered that regions with a higher density of persistent obstructions were more likely to show vessel loss with aging and vice versa. These findings indicate that age-related vessel loss is region specific and can be explained, at least partially, by regional susceptibilities to capillary plugging.

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