Quantitative measurement of sodium polystyrene sulfonate adsorption onto CTAB capped gold nanoparticles reveals hard and soft coronas

Harris, Celina M.; Miller, Savannah G.; Andresen, Kurt; Thompson, L. J.

doi:10.1016/j.jcis.2017.08.085

Cited by 13 publications

(8 citation statements)

References 28 publications

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“…To obtain CTAB-GNPs, the precipitates after centrifugation were re-dispersed in 10 mL distilled water. According to previous reports [14,15],the CTAB-GNPs were further coated with the polyelectrolyte PSSMA and BSA under stirring to obtain BSA-GNPs.…”

Section: Methodsmentioning

confidence: 99%

Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression

Huang

Liu

et al. 2018

Nanomaterials

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Gold nanoparticles (GNPs) are usually wrapped with biocompatible polymers in biomedical field, however, the effect of biocompatible polymers of gold nanoparticles on cellular responses are still not fully understood. In this study, GNPs with/without polymer wrapping were used as model probes for the investigation of cytotoxicity and cell cycle progression. Our results show that the bovine serum albumin (BSA) coated GNPs (BSA-GNPs) had been transported into lysosomes after endocytosis. The lysosomal accumulation had then led to increased binding between kinesin 5 and microtubules, enhanced microtubule stabilization, and eventually induced G2/M arrest through the regulation of cadherin 1. In contrast, the bare GNPs experienced lysosomal escape, resulting in microtubule damage and G0/G1 arrest through the regulation of proliferating cell nuclear antigen. Overall, our findings showed that both naked and BSA wrapped gold nanoparticles had cytotoxicity, however, they affected cell proliferation via different pathways. This will greatly help us to regulate cell responses for different biomedical applications.

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Section: Methodsmentioning

confidence: 99%

Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression

Huang

Liu

et al. 2018

Nanomaterials

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“…The layer-by-layer (Lbl) method of coating NPs and planar substrates using polyelectrolytes (PEs) is well established [3,4,5]. Lbl coatings with PEs have distinct advantages over other surface modification methods, specifically the ease of assembly on a wide range of substrates.…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte-Coated Gold Nanoparticles: The Effect of Salt and Polyelectrolyte Concentration on Colloidal Stability

Fuller

Köper

2018

Polymers

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Gold nanoparticles are widely used in biomedical applications. Their ease of surface modification, biocompatibility and the presence of surface plasmons makes them ideal tools for a variety of investigations. Polyelectrolyte-coated gold nanoparticles are employed in areas such as imaging, drug delivery and gene therapy; however, it is not well understood how different factors such as the polyelectrolyte and salt concentration affect the coating on the nanoparticles and hence their performance. Here, these parameters were systematically varied and their effect on the stability of the colloidal nanoparticle suspension was monitored. An increase in the polyelectrolyte concentration from 0 to 30 mg/mL led to a red shift of the surface plasmon peak and an increase in the zeta potential. Concentrations between 5 mg/mL and 30 mg/mL resulted in the most stable systems, with 1 mg/mL being the most unstable. Stable nanoparticle suspensions were formed in salt concentrations below 50 mM, while higher concentrations caused colloidal instability and irreversible aggregation.

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“…[39][40][41] In addition, the term corona is used for stabilized polymers in some publications. 42 It also has to be kept in mind that "nanoparticle" is a rather new word for a nanoscale structure. Other terms used for particles in the same or comparable size range are, for example, colloid, submicron particle, dust, ne particulate matter, and others.…”

Section: Terminologymentioning

confidence: 99%

Isolation methods for particle protein corona complexes from protein-rich matrices

et al. 2020

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Quantitative measurement of sodium polystyrene sulfonate adsorption onto CTAB capped gold nanoparticles reveals hard and soft coronas

Cited by 13 publications

References 28 publications

Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression

Effect of Surface Coating of Gold Nanoparticles on Cytotoxicity and Cell Cycle Progression

Polyelectrolyte-Coated Gold Nanoparticles: The Effect of Salt and Polyelectrolyte Concentration on Colloidal Stability

Isolation methods for particle protein corona complexes from protein-rich matrices

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