Quantitative modelling of signaling in aggressive B cell lymphoma unveils conserved core network
Bertram Klinger,
Isbael Rausch,
Anja Sieber
et al.
Abstract:B cell receptor (BCR) signaling is required for the survival and maturation of B cells and is deregulated in B cell lymphomas. While proximal BCR signaling is well studied, little is known about the crosstalk of downstream effector pathways, and a comprehensive quantitative network analysis of BCR signaling is missing. Here, we semi-quantitatively modelled BCR signaling in Burkitt lymphoma (BL) cells using systematically perturbed phosphorylation data of BL-2 and BL-41 cells. The models unveiled feedback and c… Show more
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