Quantitative monitoring of corticosteroids in cosmetic products manufactured in Korea using LC–MS/MS

Liquid chromatography/tandem mass spectrometry for simultaneous determination of undeclared corticosteroids in cosmetic creams

“…A couple of papers deal with non‐allowed drugs in cosmetic creams . Also, simultaneous analysis of 2–6 corticosteroids at low level concentrations in cosmetic preparations by means of LC/MS or LC/MS/MS has been reported …”

“…The aim of this study was to propose an LC/MS/MS method fit for routine official control of low levels of unlabelled corticosteroids in creams. The method should be suitable for simultaneous determination of eleven topical corticosteroids, more than any published method . These corticosteroids are: prednisolone, methylprednisolone, prednisolone‐21‐acetate, fluocinolone acetonide, fluocinolone acetonide‐21‐acetate, hydrocortisone‐21‐acetate, dexamethasone, betamethasone, betamethasone dipropionate, clobetasol propionate and triamcinolone (Figs.…”

“…[12,13] Also, simultaneous analysis of 2-6 corticosteroids at low level concentrations in cosmetic preparations by means of LC/MS or LC/MS/MS has been reported. [14][15][16][17] The aim of this study was to propose an LC/MS/MS method fit for routine official control of low levels of unlabelled corticosteroids in creams. The method should be suitable for simultaneous determination of eleven topical corticosteroids, more than any published method.…”

Determination of Ten Corticosteroids in Illegal Cosmetic Products by a Simple, Rapid, and High-Performance LC-MS/MS Method

“…We choose to investigate these specific corticosteroids because they are the most used ones in dermatologic field and to ensure that the investigation is carried out as widely as possible. In the above-mentioned classification, CLP 0.05% (v/v) is classified in class I, with a potency that is 1800 times higher compared to hydrocortisone [16]. DEX, FLM, MPD, and PDL are classified in class VII, with TRA classified in class III.…”

Simultaneous determination of 16 fluoroquinolone antibiotics in cosmetics by ultra-performance liquid chromatography/triple quadrupole mass spectrometry with ultrasound-assisted extraction and solid-phase extraction

“…In general, the vast majority of cosmetics manufacturers act responsibly, and voluntary addition of prohibited ingredients is very scarce. 35 However, in order to achieve anti-acne, anti-freckle, anti-wrinkle, skin-whitening or astringent efficacy in a short term, illicit substances, e.g., antibiotics 2 and corticosteroids 3,4 , might be intentionally added to cosmetic products by a few lawbreakers for economic benefit, hence posing a serious risk to human health. 40 Fluoroquinolones (FQs) are a large group of broad-spectrum synthetic antibiotics, which have been initially used for the treatment of the infectious diseases of humans and foodproducing animals, since they are effective against both Grampositive and Gram-negative bacteria 5 .…”