Quantitative myocardial first-pass cardiovascular magnetic resonance perfusion imaging using hyperpolarized [1-13C] pyruvate

Füetterer, Maximilian; Busch, Julia; Traechtler, Julia; Wespi, Patrick; Peereboom, Sophie M.; Sauer, Mareike; Lipiski, Miriam; Fleischmann, Thea; Cesarovic, Nikola; Stoeck, Christian T.; Kozerke, Sebastian

doi:10.1186/s12968-018-0495-2

Cited by 20 publications

(21 citation statements)

References 52 publications

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“…This metabolic CMR may potentially be involved also in evaluation of myocardial viability and ischemia in the future. 99,100 Conclusions As laid out in our review of the current literature, CMR plays a leading role in the diagnostic workup of patients with CCS. It allows an assessment of myocardial function, ischemia, and viability within a single noninvasive examination over a short period of time.…”

Section: % 100%mentioning

confidence: 90%

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Sokolska¹,

Spiczak²,

Gotschy³

et al. 2019

Kardiol Pol

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The new 2019 European Society of Cardiology guidelines for the diagnosis and management of chronic coronary syndromes emphasize the role of noninvasive functional imaging of myocardial ischemia in diagnosing coronary artery disease to guide decision making regarding revascularization. Cardiac magnetic resonance imaging (CMR) stands out relative to other imaging modalities given its high safety profile, absence of ionizing radiation, and its versatility in encoding various image contrasts. It also allows an assessment of myocardial function, ischemia, and viability as well as permits tissue characterization including detection of edema in a single examination. In recent years, a number of meta-analyses and studies considering the role of CMR for detecting ischemia have been published. The recent multicenter randomized MR-INFORM trial has demonstrated the clinical utility of CMR in patients with stable angina and cardiovascular risk factors. This landmark study has proved that a perfusion CMR-based strategy leads to a lower number of revascularizations while being noninferior to an invasive coronary angiography with fractional flow reserve-guided therapy in terms of major adverse cardiac events at 1 year. In light of recent and future technical improvements, CMR will become increasingly important in the assessment of myocardial ischemia in patients with chronic coronary syndromes.

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Section: % 100%mentioning

confidence: 90%

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Sokolska¹,

Spiczak²,

Gotschy³

et al. 2019

Kardiol Pol

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“…Physiological parameters were chosen in a way that metabolism in simulated data reflects metabolism as observed in vivo. Polarization loss due to longitudinal relaxation was assumed to be spatially invariant (

T_{1, p y r}

T_{1, p y r H}

= 30 seconds,

T_{1, l a c}

T_{1, b i c}

T_{1, a l a}

= 20 seconds 36 ), and applied to the signal dynamics (

t_{d}

= 0, 2, …, 80 seconds). High‐resolution (1 × 1 mm 2 in‐plane) anatomical masks were derived as a stack of 2D slices from segmentations of in vivo proton‐based cardiac images in short‐axis view, and scaled according to the metabolic signal dynamics.…”

Section: Methodsmentioning

confidence: 99%

Joint image and field map estimation for multi‐echo hyperpolarized ¹³C metabolic imaging of the heart

Traechtler

Vishnevskiy

Füetterer

et al. 2021

Magnetic Resonance in Med

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Image reconstruction of metabolic images from hyperpolarized 13 C multiecho data acquisition is sensitive to susceptibility-induced phase offsets, which are particularly challenging in the heart. A model-based framework for joint estimation of metabolite images and field map from echo shift-encoded data is proposed. Using simulations, it is demonstrated that correction of signal spilling due to incorrect decomposition of metabolites and geometrical distortions over a wide range of offresonance gradients is possible. In vivo feasibility is illustrated using hyperpolarized [1-13 C]pyruvate in the pig heart. Methods: The model-based reconstruction for multi-echo, multicoil data was implemented as a nonconvex minimization problem jointly optimizing for metabolic images and B 0. A comprehensive simulation framework for echo shift-encoded hyperpolarized [1-13 C]pyruvate imaging was developed and applied to assess reconstruction performance and distortion correction of the proposed method. In vivo data were obtained in four pigs using hyperpolarized [1-13 C]pyruvate on a clinical 3T MR system with a six-channel receiver coil. Dynamic images were acquired during suspended ventilation using cardiac-triggered multi-echo single-shot echo-planar imaging in short-axis orientation. Results: Simulations revealed that off-resonance gradients up to ±0.26 ppm/pixel can be corrected for with reduced signal spilling and geometrical distortions yielding an accuracy of ≥90% in terms of Dice similarity index. In vivo, improved geometrical consistency (10% Dice improvement) compared to image reconstruction without field map correction and with reference to anatomical data was achieved. Conclusion: Joint image and field map estimation allows addressing off-resonanceinduced geometrical distortions and metabolite spilling in hyperpolarized 13 C metabolic imaging of the heart.

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“…Absolute myocardial blood flow quantification would be preferred and hyperpolarized 13 C pyruvate contrast offers this opportunity. In this theoretical and swine study by Fuetterer and co-workers [173], simulations and in-vivo swine images suggested that 13 C pyruvate contrast provided sufficient SNR for both absolute and semi-quantitative perfusion.…”

Section: Animal Modelsmentioning

confidence: 97%

Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review

Manning

2019

Journal of Cardiovascular Magnetic Resonance

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There were 89 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2017, including 76 original research papers, 4 reviews, 5 technical notes, 1 guideline, and 3 corrections. The volume was down slightly from 2017 with a corresponding 15% decrease in manuscript submissions from 405 to 346 and thus reflects a slight increase in the acceptance rate from 25 to 26%. The decrease in submissions for the year followed the initiation of the increased author processing charge (APC) for Society for Cardiovascular Magnetic Resonance (SCMR) members for manuscripts submitted after June 30, 2018. The quality of the submissions continues to be high. The 2018 JCMR Impact Factor (which is published in June 2019) was slightly lower at 5.1 (vs. 5.46 for 2017; as published in June 2018. The 2018 impact factor means that on average, each JCMR published in 2016 and 2017 was cited 5.1 times in 2018. Our 5 year impact factor was 5.82.In accordance with Open-Access publishing guidelines of BMC, the JCMR articles are published on-line in a continuus fashion in the chronologic order of acceptance, with no collating of the articles into sections or special thematic issues. For this reason, over the years, the Editors have felt that it is useful for the JCMR audience to annually summarize the publications into broad areas of interest or themes, so that readers can view areas of interest in a single article in relation to each other and contemporaneous JCMR publications. In this publication, the manuscripts are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought within the journal. In addition, as in the past two years, I have used this publication to also convey information regarding the editorial process and as a “State of our JCMR.”This is the 12th year of JCMR as an open-access publication with BMC (formerly known as Biomed Central). The timing of the JCMR transition to the open access platform was “ahead of the curve” and a tribute to the vision of Dr. Matthias Friedrich, the SCMR Publications Committee Chair and Dr. Dudley Pennell, the JCMR editor-in-chief at the time. The open-access system has dramatically increased the reading and citation of JCMR publications and I hope that you, our authors, will continue to send your very best, high quality manuscripts to JCMR for consideration. It takes a village to run a journal and I thank our very dedicated Associate Editors, Guest Editors, Reviewers for their efforts to ensure that the review process occurs in a timely and responsible manner. These efforts have allowed the JCMR to continue as the premier journal of our field. This entire process would also not be possible without the dedication and efforts of our managing editor, Diana Gethers. Finally, I thank you for entrusting me with the editorship of the JCMR as I begin my 4th year as your editor-in-chief. It has been a tremendous experience for me and the opportunity to review manuscripts that reflect the best in our field rema...

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Quantitative myocardial first-pass cardiovascular magnetic resonance perfusion imaging using hyperpolarized [1-13C] pyruvate

Cited by 20 publications

References 52 publications

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Joint image and field map estimation for multi‐echo hyperpolarized ¹³C metabolic imaging of the heart

Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review

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Quantitative myocardial first-pass cardiovascular magnetic resonance perfusion imaging using hyperpolarized [1-13C] pyruvate

Cited by 20 publications

References 52 publications

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Cardiac magnetic resonance imaging to detect ischemia in chronic coronary syndromes: state of the art

Joint image and field map estimation for multi‐echo hyperpolarized 13C metabolic imaging of the heart

Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review

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Joint image and field map estimation for multi‐echo hyperpolarized ¹³C metabolic imaging of the heart