Quantitative PET Findings in Patients with Posttraumatic Anosmia

Varney, Nils R.; Pinkston, James B.; Wu, Joseph C.

doi:10.1097/00001199-200106000-00004

Cited by 53 publications

(32 citation statements)

References 16 publications

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“…Neuropsychiatric disorders that feature impulsivity (i.e., Borderline Personality disorder, Tourette's syndrome, traumatic brain injury) are associated with PFC dysfunction, as demonstrated by results of several of neuroimaging studies (44)(45)(46). Similarly, reports from electrophysiological studies in adolescents with conduct problems and adults with alcoholism have linked inhibitory control impairment and PFC dysfunction.…”

Section: The Neurobiological Basis Of Inhibitory Control: Role Of Thementioning

confidence: 97%

Inhibitory Control Deficits in Childhood and Risk for Substance Use Disorders: A Review

Ivanov

Schulz

London

et al. 2008

The American Journal of Drug and Alcohol Abuse

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Identification of neurobiological factors that confer risk for the development of addiction may substantially advance development of new prevention and treatment strategies to combat substance use disorders. This review focuses on the relationship between impulsivity - a behavior that is common to the clinical picture of both substance use disorders (SUD) and childhood disruptive behavior disorders - and neurobiological risk for SUD. It further examines various behaviors within the over-arching domain of impulsivity, ultimately focusing on the more narrowly defined and measurable construct of inhibitory control, and concluding that underlying deficits in inhibitory control may be central to many of the behaviors associated with high risk for SUD. Targeted cross-sectional study of the neural basis of inhibitory dyscontrol in subjects at high risk for SUD, who have not yet begun to abuse drugs, has the potential to generate important hypotheses regarding the neurobiological underpinnings of SUD risk. Hypotheses developed using this approach can be more definitively evaluated in longitudinal studies with these same populations, extending through the period of maximal risk for SUD in adolescence and early adulthood.

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Section: The Neurobiological Basis Of Inhibitory Control: Role Of Thementioning

confidence: 97%

Inhibitory Control Deficits in Childhood and Risk for Substance Use Disorders: A Review

Ivanov

Schulz

London

et al. 2008

The American Journal of Drug and Alcohol Abuse

View full text Add to dashboard Cite

show abstract

“…Other imaging modalities such as single-photon emission computed tomography (SPECT) and positron-emission tomography (PET) have been investigated in patients with olfactory dysfunction with promising findings [62][63][64]. However as they were not used in patients whose loss was specifically posttraumatic loss the diagnostic role of these tests remains to be elucidated.…”

Section: Neuroimagingmentioning

confidence: 99%

Posttraumatic olfactory dysfunction

Coelho

Costanzo

2016

Auris Nasus Larynx

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“…When using SPECT to investigate brain activity in posttraumatic anosmia, researchers found reduced perfusion in frontal, left parietal and left temporal regions [15]. Another study confirmed reduced metabolism in the median prefrontal cortex and the orbitofrontal cortex of patients with posttraumatic anosmia [16]. Moreover, a recent functional imaging study done with patients with obsessive compulsive disorder showed the importance of the orbitofrontal cortex and the pre-frontal cortex in odour perception, with results supporting connections between the orbitofrontal cortex and the olfactory sensory system in a clinical population [17].…”

Section: Introductionmentioning

confidence: 95%