Quantitative Pupillometry Values are Remarkably Similar Before and After Neuroimaging

Olson, DaiWai M.; Stutzman, Sonja E.; Olson, DaiWai M.; Reyes, Ranier

doi:10.1016/j.jradnu.2023.03.001

Cited by 1 publication

(2 citation statements)

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“…However, with our preliminary data and an effect size calculation at 0.042, a population of 5959 patients would be required to detect any subtle differences. A previous study has also supported the accuracy and stability of PLR metrics when no neurological change has occurred 41. By assessing the discrete elements of the PLR before and after angiography, our study provides insights for future research as the values did not statistically.…”

Section: Discussionsupporting

confidence: 66%

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Prospective study examining the impact of cerebral angiography on quantitative pupillometer values in the interventional radiology suite

Nguyen,

Marshall,

Rana

et al. 2024

BMJ Open

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ObjectivesThe purpose of this pilot study was to obtain baseline quantitative pupillometry (QP) measurements before and after catheter-directed cerebral angiography (DCA) to explore the hypothesis that cerebral angiography is an independent predictor of change in pupillary light reflex (PLR) metrics.DesignThis was a prospective, observational pilot study of PLR assessments obtained using QP 30 min before and after DCA. All patients had QP measurements performed with the NPi-300 (Neuroptics) pupillometer.SettingRecruitment was done at a single-centre, tertiary-care academic hospital and comprehensive stroke centre in Dallas, Texas.ParticipantsFifty participants were recruited undergoing elective or emergent angiography. Inclusion criteria were a physician-ordered interventional neuroradiological procedure, at least 18 years of age, no contraindications to PLR assessment with QP, and nursing transport to and from DCA. Patients with a history of eye surgery were excluded.Main outcome measuresDifference in PLR metric obtained from QP 30 min before and after DCA.ResultsStatistically significant difference was noted in the pre and post left eye readings for the minimum pupil size (a.k.a., pupil diameter on maximum constriction). The mean maximum constriction diameter prior to angiogram of 3.2 (1.1) mm was statistically larger than after angiogram (2.9 (1.0) mm; p<0.05); however, this was not considered clinically significant. Comparisons for all other PLR metrics pre and post angiogram demonstrated no significant difference. Using change in NPi pre and post angiogram (Δpre=0.05 (0.77) vs Δpost=0.08 (0.67); p=0.62), we calculated the effect size as 0.042. Hence, detecting a statistically significant difference in NPi, if a difference exists, would require a sample size of ~6000 patients.ConclusionsOur study provides supportive data that in an uncomplicated angiogram, even with intervention, there is no effect on the PLR.

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Section: Discussionsupporting

confidence: 66%

“…A previous study has also supported the accuracy and stability of PLR metrics when no neurological change has occurred. 41 By assessing the discrete elements of the PLR before and after angiography, our study provides insights for future research as the values did not statistically.…”

Section: Discussionmentioning

confidence: 91%