Quantitative Radiologic Imaging Techniques for Articular Cartilage Composition: Toward Early Diagnosis and Development of Disease‐Modifying Therapeutics for Osteoarthritis

Oei, Edwin H.G.; Tiel, Jasper van; Robinson, William H.; Gold, Garry E.

doi:10.1002/acr.22316

Cited by 67 publications

(79 citation statements)

References 177 publications

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“…These results are consistent with those from previous research showing a strong correlation between T1 relaxation times at dGEMRIC acquired in vitro and ex vivo in cadaveric animal cartilage after microfracture treatment and human osteoarthritis cartilage (5,33). Our results are also in agreement with those of the only in vivo validation study of dGEMRIC, which was performed by Watanabe et al (13) in 2006 and found a strong correlation (r = 0.82) between outcomes of dGEMRIC after treatment of focal cartilage defects and cartilage (4). T1r mapping performed with a spin-lock frequency higher than 500 Hz has been described as safe (8); however, we applied a 500-Hz spin-lock frequency because this is most commonly used in vivo, enabling us to compare our results with those Spatial agreement between dGEMRIC, T1r mapping, equilibrium partitioning of an ionic contrast material by using micro-CT (EPIC-mCT ), and histologic examination.…”

Section: Discussionsupporting

confidence: 82%

“…These disadvantages are mainly related to the administration of contrast material, which increases costs and is potentially harmful to patients with impaired renal function, and the long delay between contrast material administration and MR imaging. Because of these drawbacks, T1r mapping was suggested as a non-contrast-enhanced alternative to dGEMRIC for the measurement of sGAG content (3,4,6). In T1r mapping, the spin relaxation is quantified in the rotating frame by using a constant radiofrequency field referred to as a "spinlock" pulse to change relaxation rates of water associated with large macromolecules in cartilage such as sGAG (7,8).…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…Our study was approved by the Medical Ethical Committee of example, sulphated glycosaminoglycan (sGAG) content, have become of interest during the past decade (4).…”

Section: Study Design and Participantsmentioning

confidence: 99%

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Is T1ρ Mapping an Alternative to Delayed Gadolinium-enhanced MR Imaging of Cartilage in the Assessment of Sulphated Glycosaminoglycan Content in Human Osteoarthritic Knees? An in Vivo Validation Study

Tiel¹,

Kotek

Reijman

et al. 2016

Radiology

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).q RSNA, 2015 Purpose:To determine if T1r mapping can be used as an alternative to delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the quantification of cartilage biochemical composition in vivo in human knees with osteoarthritis. Materials and Methods:This study was approved by the institutional review board. Written informed consent was obtained from all participants. Twelve patients with knee osteoarthritis underwent dGEMRIC and T1r mapping at 3.0 T before undergoing total knee replacement. Outcomes of dGEMRIC and T1r mapping were calculated in six cartilage regions of interest. Femoral and tibial cartilages were harvested during total knee replacement. Cartilage sulphated glycosaminoglycan (sGAG) and collagen content were assessed with dimethylmethylene blue and hydroxyproline assays, respectively. A four-dimensional multivariate mixed-effects model was used to simultaneously assess the correlation between outcomes of dGEMRIC and T1r mapping and the sGAG and collagen content of the articular cartilage. Results:T1 relaxation times at dGEMRIC showed strong correlation with cartilage sGAG content (r = 0.73; 95% credibility in- Conclusion:dGEMRIC can help accurately measure cartilage sGAG content in vivo in patients with knee osteoarthritis, whereas T1r mapping does not appear suitable for this purpose. Although the technique is not completely sGAG specific and requires a contrast agent, dGEMRIC is a validated and robust method for quantifying cartilage sGAG content in human osteoarthritis subjects in clinical research.q RSNA, 2015

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Section: Discussionsupporting

confidence: 82%

Section: Study Design and Participantsmentioning

confidence: 99%

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Is T1ρ Mapping an Alternative to Delayed Gadolinium-enhanced MR Imaging of Cartilage in the Assessment of Sulphated Glycosaminoglycan Content in Human Osteoarthritic Knees? An in Vivo Validation Study

Tiel¹,

Kotek

Reijman

et al. 2016

Radiology

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“…Identifying changes in the extracellular matrix of the cartilage can play a vital role in early detection of osteoarthritis [1][2][3]. Sulfated glycosaminoglycans (sGAG or GAG) are one of the predominant extracellular matrix components in healthy articular cartilage.…”

Section: Introductionmentioning

confidence: 99%

Quantitative imaging of excised osteoarthritic cartilage using spectral CT

et al. 2016

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“…Despite its prevalence, pathogenesis in OA is still poorly understood. There is great need for imaging biomarkers of early changes in OA in order to better understand the disease process as well as to develop new therapies (50,51).…”

Section: Osteoarthritis (Oa)mentioning

confidence: 99%

Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease

Kogan

Fan

Gold

2016

Quant. Imaging Med. Surg.

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Early detection of musculoskeletal disease leads to improved therapies and patient outcomes, and would benefit greatly from imaging at the cellular and molecular level. As it becomes clear that assessment of multiple tissues and functional processes are often necessary to study the complex pathogenesis of musculoskeletal disorders, the role of multi-modality molecular imaging becomes increasingly important.New positron emission tomography-magnetic resonance imaging (PET-MRI) systems offer to combine high-resolution MRI with simultaneous molecular information from PET to study the multifaceted processes involved in numerous musculoskeletal disorders. In this article, we aim to outline the potential clinical utility of hybrid PET-MRI to these non-oncologic musculoskeletal diseases. We summarize current applications of PET molecular imaging in osteoarthritis (OA), rheumatoid arthritis (RA), metabolic bone diseases and neuropathic peripheral pain. Advanced MRI approaches that reveal biochemical and functional information offer complementary assessment in soft tissues. Additionally, we discuss technical considerations for hybrid PET-MR imaging including MR attenuation correction, workflow, radiation dose, and quantification.

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Quantitative Radiologic Imaging Techniques for Articular Cartilage Composition: Toward Early Diagnosis and Development of Disease‐Modifying Therapeutics for Osteoarthritis

Cited by 67 publications

References 177 publications

Is T1ρ Mapping an Alternative to Delayed Gadolinium-enhanced MR Imaging of Cartilage in the Assessment of Sulphated Glycosaminoglycan Content in Human Osteoarthritic Knees? An in Vivo Validation Study

Is T1ρ Mapping an Alternative to Delayed Gadolinium-enhanced MR Imaging of Cartilage in the Assessment of Sulphated Glycosaminoglycan Content in Human Osteoarthritic Knees? An in Vivo Validation Study

Quantitative imaging of excised osteoarthritic cartilage using spectral CT

Potential of PET-MRI for imaging of non-oncologic musculoskeletal disease

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