Quantitative Relation Between Certain Fibrinolysis Factors and Inflammation

Aschheim, Emil; Tsuluca, V.; Copley, Alfred L.

doi:10.3181/00379727-112-28068

Cited by 14 publications

(5 citation statements)

References 1 publication

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“…We employed human radioalbumin because species specificity is not neces sary in permeability studies [1,2]. Blood was withdrawn by a polythene catheter placed in an iliac artery.…”

Section: Methodsmentioning

confidence: 99%

Increased Capillary Permeability in Haemophilia and Afibrinogenaemia

Serneri¹,

Gensini²,

Gensini³

1974

Acta Haematol

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In patients with various disorders of haemostasis and in 13 controls we studied the capillary permeability to human ⁹⁹Tc-albumin. In 16 haemophiliacs, in 2 afibrinogenaemics and in 1 out of 3 patients with von Willebrand’s disease with a factor VIII level of about 15% we observed a marked increase of capillary permeability. On the contrary, 2 patients with a congenital lack of factor V, 2 cases of von Willebrand’s disease with a factor VIII level of about 50% and 3 subjects with ITP showed a normal capillary permeability. The administration of a single small dose of factor VIII (1 U/kg) or IX (2 U/kg) or fibrinogen (15 mg/kg) which did not improve the clotting disorder corrected the permeability for at least 3 days. The induction of a severe clotting disorder by heparin administration in man and by anticoagulant treatment in rabbits did not change the capillary permeability. These results support the hypothesis that antihaemophilic factors and fibrinogen could be involved in the composition and functions of the vascular wall.

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“…We employed human radioalbumin because species specificity is not neces sary in permeability studies [1,2]. Blood was withdrawn by a polythene catheter placed in an iliac artery.…”

Section: Methodsmentioning

confidence: 99%

Increased Capillary Permeability in Haemophilia and Afibrinogenaemia

Serneri¹,

Gensini²,

Gensini³

1974

Acta Haematol

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“…Enhanced intrahepatic fibrinolysis did not follow small doses of SK or trypsin (Table 2); indeed the fibrinolytic activity was somewhat lower than normal following low SK or trypsin dosage. Copley (41), Ascheim (42) and one of us have (43) reported that plasmin can decrease vascular and tissue permeability. The pro-coagulant, antiinflammatory effect of protease in low dosage is entirely consistent with decreased vascular, tissue and cellular permeability, and, indeed, may even account for it.…”

Section: Discussionmentioning

confidence: 99%

The Rat Plasminogen System, Intrahepatic Fibrinolysis and Carbon Tetrachloride Hepatotoxicity

Innerfield¹,

Gr²,

Zwell³

et al. 1967

Thromb Haemost

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SummaryCarbon tetrachloride hepatotoxicity in rats is significantly reduced by small doses of orally given enzymes which activate the rat plasminogen system. Enzymes incapable of activating rat plasminogen are ineffective. The suggestion is made that the liver protection afforded by small doses of SK or trypsin relates to the pro-coagulant, permeability-decreasing, anti-edema action of suitably low doses of SK or trypsin.

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“…Preplasmin, on the other band, was found to produce an increase in capillary permeability which, like that of kallidin-9, could be suppressed by the simultaneous injection of plasmin [7]. Although the intravenous injection of either preplasmin or kallidin-9 followed by the intradermal injection of the opposite agent resulted in a moderate decrease of capillary perme ability, their simultaneous injection resulted in an increase in permeability [96].…”

Section: Interrelationship Of Human Plasma Kallikrein and Plasmin In mentioning

confidence: 95%

“…It has been suggested [5] that proteolytic enzymes initiate the inflammatory reaction. On the other hand, evidence for suppression of the inflammatory response following parenteral or buccal administration of a variety of proteolytic enzymes such as trypsin, streptokinase, plasmin and chymotrypsin is well documented [6,7]. Two endogenous proteolytic enzyme systems which have been studied in recent years could represent an enzymatically controlled system of biological antagonism designed to initiate and restore tissue homeostasis in inflammed tissue.…”

Section: Interrelationship Of Human Plasma Kallikrein and Plasmin In mentioning

confidence: 99%