Quantitative relationship of fecal asbestos to asbestos exposure

Cunningham, H. M.; Pontefract, R. D.; O'Brien, R. C.

doi:10.1080/15287397609529337

Cited by 11 publications

(5 citation statements)

References 4 publications

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“…Penetration of ingested asbestos fibers through gastrointestinal tract and recovery of migrated fibers in distant tissues have been reported in animal and human studies (6)(7)(8)(9)(10)(11)(12)(13)(17)(18)(19). Contrary to this, other studies (20)(21)(22) indicate that ingested fibers do not penetrate or migrate.…”

Section: Discussionmentioning

confidence: 37%

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Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Patel-Mandlik¹,

Millette²

1983

Environmental Health Perspectives

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With the use of the transmission electron microscope, asbestos fibers have been assessed in kidney cortex of four groups of rats previously exposed to intermediate-range feeding grade chrysotile asbestos. Newborn rats, from mothers gavaged with asbestos during pregnancy, were gavaged twice a week at the dose level of 50 mg/kg beginning at age day 7 until their natural death or sacrifice. The rats were divided into four groups by age: 0-200, 200-400, 400-600 and 600-800 days. Of the 20 rats comprising the four test groups, 17 were positive, average fiber recovery being 5.34 x 103/mg dry weight. Average fiber level in control tissues was 0.23 x 103/mg dry weight. Fiber recovery in tissues from control animals was shown to be significantly lower (p < 0.005) than that from test tissues. Test groups showed highly significant differences (p < 0.005) from each other in the fiber levels. Dose-response relationship was not significant (0.05 < p < 0.1). The length distribution and the alterations in morphology of the recovered fibers are described. This study is consistent with the passage of chrysotile asbestos across the gastrointestinal wall.

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Section: Discussionmentioning

confidence: 37%

“…There was a rise in fiber level in the tissues from group I to group III rats, followed by a drop in the tissues from group IV rats (Table 1). Rat group IV received cumulatively more fibers than rat groups III, II or I because the rats in this study were (6,18,19). No relationship was observed with Class A + B fiber counts.…”

Section: Discussionmentioning

confidence: 61%

Accumulation of Ingested Asbestos Fibers in Rat Tissues over Time

Patel-Mandlik¹,

Millette²

1983

Environmental Health Perspectives

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“…On accepting statistical significance for p values < 0.1, the quadratic model of regression analysis revealed a relation (p < 0.08) between dosage and number of fibers of Class A + B + C retained in the kidney cortex. The quadratic relationship could signify time-related biological causes of low fiber recovery, such as degradation of fibers beyond TEM identity and elimination of fibers in feces and urine (6,18,19). No relationship was observed with Class A + B fiber counts.…”

Section: Discussionmentioning

confidence: 99%

Accumulation of ingested asbestos fibers in rat tissues over time.

Patel-Mandlik¹,

Millette²

1983

Environ Health Perspect

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With the use of the transmission electron microscope, asbestos fibers have been assessed in kidney cortex of four groups of rats previously exposed to intermediate-range feeding grade chrysotile asbestos. Newborn rats, from mothers gavaged with asbestos during pregnancy, were gavaged twice a week at the dose level of 50 mg/kg beginning at age day 7 until their natural death or sacrifice. The rats were divided into four groups by age: 0-200, 200-400, 400-600 and 600-800 days. Of the 20 rats comprising the four test groups, 17 were positive, average fiber recovery being 5.34 X 10(3)/mg dry weight. Average fiber level in control tissues was 0.23 X 10(3)/mg dry weight. Fiber recovery in tissues from control animals was shown to be significantly lower (p less than 0.005) than that from test tissues. Test groups showed highly significant differences (p less than 0.005) from each other in the fiber levels. Dose-response relationship was not significant (0.05 less than p less than 0.1). The length distribution and the alterations in morphology of the recovered fibers are described. This study is consistent with the passage of chrysotile asbestos across the gastrointestinal wall.

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“…Clearly, although it is easy enough to estimate the probable concentrations taken in during the consumption of water over time (without regard, of course, to the contributions from beverages and food), it is extremely difficult to determine the ratio of fibers retained or excreted. From the work of Cunningham et al (8) on the accumulation of asbestos fibers in the feces of workers exposed to moderate to high industrial levels of chrysotile, it appears that around 12-26 x 106 fibers/gm of feces (perhaps 12-52 x 108 fibers in a 24-hr specimen) may be present. Control subjects yield about 0.4 x 106 fibers/g of feces.…”

Section: Introductionmentioning

confidence: 95%