Quantitative scanning acoustic microscopy compared to microradiography for assessment of new bone formation

Regauer, M.; Jürgens, Philipp; Hartstock, Martina; Böcker, Wolfgang; Bürklein, Dominik; Mutschler, Wolf; Sader, Robert; Schieker, Matthias

doi:10.1016/j.bone.2005.09.005

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…A focused acoustic beam was scanned over the in-situ specimen using a piezoelectric transducer and a spherically focused sapphire lens with 50 MHz probe in a gated pulse-echo mode. Two different ways were used to analyze the reflected signals, namely the C-scan and the time-of-flight (TOF) analyses [12,13]. The resolution provided by the system was approximately 20 m. In C-scan analysis, the images can be generated from the micro-void at all depth of the specimen.…”

Section: Methodsmentioning

confidence: 99%

The correlation between microstructure and mechanical properties of high-pressure die-cast AM50 alloy

Song

Xiong

et al. 2009

Journal of Alloys and Compounds

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Section: Methodsmentioning

confidence: 99%

The correlation between microstructure and mechanical properties of high-pressure die-cast AM50 alloy

Song

Xiong

et al. 2009

Journal of Alloys and Compounds

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“…The beam scans the surface of the object and the resulting image is based on the variation in velocity of the ultrasound inside the bone matrix. The gray levels of the image reflect the The system was used on cortical and trabecular bone; images were always compared to microradiography or SEM-BSE for relating data with the mineralization degree [84][85][86]. Areas with low mineral density (newly formed BSUs or the cement lines around the osteons) have a lower value in scanning acoustic microscopy (SAM).…”

Section: Scanning Acoustic Microscopymentioning

confidence: 99%

New laboratory tools in the assessment of bone quality

et al. 2011

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Bone quality is a complex set of intricated and interdependent factors that influence bone strength. A number of methods have emerged to measure bone quality, taking into account the organic or the mineral phase of the bone matrix, in the laboratory. Bone quality is a complex set of different factors that are interdependent. The bone matrix organization can be described at five different levels of anatomical organization: nature (organic and mineral), texture (woven or lamellar), structure (osteons in the cortices and arch-like packets in trabecular bone), microarchitecture, and macroarchitecture. Any change in one of these levels can alter bone quality. An altered bone remodeling can affect bone quality by influencing one or more of these factors. We have reviewed here the main methods that can be used in the laboratory to explore bone quality on bone samples. Bone remodeling can be evaluated by histomorphometry; microarchitecture is explored in 2D on histological sections and in 3D by microCT or synchrotron. Microradiography and scanning electron microscopy in the backscattered electron mode can measure the mineral distribution; Raman and Fourier-transformed infra-red spectroscopy and imaging can simultaneously explore the organic and mineral phase of the matrix on multispectral images; scanning acoustic microscopy and nanoindentation provide biomechanical information on individual trabeculae. Finally, some histological methods (polarization, surface staining, fluorescence, osteocyte staining) may also be of interest in the understanding of quality as a component of bone fragility. A growing number of laboratory techniques are now available. Some of them have been described many years ago and can find a new youth; others having benefited from improvements in physical and computer techniques are now available.

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“…SAM technology offers comprehensive evaluations of both biological samples and bio-mimicked synthetic materials, providing invaluable insights for the advancement of material development. SAM has been previously used for imaging details of bone and dental structures [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Uncertainty Quantification in Acoustic Impedance of Atlantic Salmon Fish Scale using Scanning Acoustic Microscopy

Agarwal,

Ojha,

Dalmo

et al. 2023

Preprint

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Scanning Acoustic Microscopy (SAM) emerges as a versatile label-free imaging technology with broad applications in biomedical imaging, non-destructive testing, and material research. This article presents a framework for the estimation of stochastic impedance through SAM, with a particular focus on its application to the salmon fish scale. The framework leverages uncertain reflectance, marking its pioneering application to uncertainty quantification in the acoustic impedance of fish scales through acoustic responses. The study uses maximal overlap discrete wavelet transform, to decompose acoustic responses effectively and is further processed to predict the acoustic impedance. To establish the effectiveness of the proposed framework, well-known materials like a pair of target medium (polyvinylidene fluoride) and reference medium (polyimide) are employed for impedance characterization. Results demonstrate over 90%accuracy in PVDF impedance estimation, validating the framework. A stochastic impedance map, using Kriging with a Gaussian variogram, offers insights into the complex biomechanics of a fish’s scale.

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Quantitative scanning acoustic microscopy compared to microradiography for assessment of new bone formation

Cited by 6 publications

References 30 publications

The correlation between microstructure and mechanical properties of high-pressure die-cast AM50 alloy

The correlation between microstructure and mechanical properties of high-pressure die-cast AM50 alloy

New laboratory tools in the assessment of bone quality

Uncertainty Quantification in Acoustic Impedance of Atlantic Salmon Fish Scale using Scanning Acoustic Microscopy

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