Quantitative Scanning Microwave Microscopy of the Evolution of a Live Biological Cell in a Physiological Buffer

Jin, Xin; Farina, Marco; Wang, Xiaopeng; Fabi, Gianluca; Cheng, Xuanhong; Hwang, J.C.M.

doi:10.1109/tmtt.2019.2941850

Cited by 23 publications

(8 citation statements)

References 24 publications

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“…Same measurements were performed for the distilled water, where Debye fitting parameters to ref. 8, that coincide remarkably with what reported in ref. 9 at 23 °C, are ε ∞ = 5.14, ε S = 79.11, σ = 0 and τ = 8.50 pS.…”

Section: Resultssupporting

confidence: 92%

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Analytical expressions for spreading resistance in lossy media and their application to the calibration of scanning microwave microscopy

et al. 2023

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Section: Resultssupporting

confidence: 92%

“…To calibrate SMM measurements in DMEM, we have fitted the measurements reported in ref. 8 in the frequency range of 1–9 GHz to a single-pole Debye model and extracted the conductivity from the imaginary part of the dielectric constant. Single-pole Debye model for salty liquid can be expressed as 9 and results of fitting are shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

Analytical expressions for spreading resistance in lossy media and their application to the calibration of scanning microwave microscopy

et al. 2023

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“…The ability to characterize the nucleus may lead to a better differentiation of normal and cancerous cells because that is where the major difference resides. To resolve the nucleus of a live cell spatially and noninvasively, a scanning microwave microscope based on the same device architecture was demonstrated [313]. It is quite a lot of progress as the concept was originated more than a century ago, when Höber believed that an ac signal could noninvasively penetrate through a cell membrane to detect what was inside a live cell.…”

Section: B Biological Cell Probingmentioning

confidence: 99%

Applications of Microwaves in Medicine

Chiao

Lin

et al. 2023

IEEE J. Microw.

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Advances and updates in medical applications utilizing microwave techniques and technologies are reviewed in this paper. The article aims to provide an overview of enablers for microwave medical applications and their recent progress. The emphasis focuses on the applications of microwaves, in the following order, for 1) signal and data communication for implants and wearables through the human body, 2) electromagnetic energy transfer through tissues, 3) noninvasive, remote or in situ physical and biochemical sensing, and 4) therapeutic purposes by changing tissue properties with controlled thermal effects. For signal and data communication and wireless power transfer, implant and wearable applications are discussed in the categories of pacemakers, endoscopic capsules, brain interfaces, intraocular, cardiac and intracranial pressure sensors, neurostimulators, endoluminal implants, artificial retina, smart lenses, and cochlear implants. For noninvasive sensing, remote vital sign radar, biological cell probing, magnetic resonance and microwave imaging, biochemical, blood glucose, hydration and biomarker sensing applications are introduced. For therapeutic uses, the developments of microwave ablation, balloon angioplasty, and hyperthermia applications are reviewed. The scopes of this article mainly concentrate on the research and development efforts in the past 20 years. Recent review articles on specific topics are cited with accomplishment highlights and trends deliberated. At the end of this article, a brief history of the IEEE Microwave Theory and Techniques Society (MTT-S) Biological Effects and Medical Applications committee and the contributions by its members to the promotion and advancement of microwave technologies in medical fields are chronicled.

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“…For the Farina/Hwang team, improvements in resolution, calibration, throughput, and frequency range, quickly followed their initial developments [31], [114], [115], culminating in a real time (more than 2 hour) SMM measurement sequence on living mouse myoblast cells in DMEM (nutrient solution) [116] in 2019 (Figure 8).…”

Section: Smm Applications In Biologymentioning

confidence: 99%

Microwaves Are Everywhere: “SMM: Nano-Microwaves”

Siegel

2021

IEEE J. Microw.

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If the Twentieth Century boasted of the Space Age and the Computer Age, the Twenty-First Century is certainly starting off with the Age of Biology, or at least Biochemistry. The enormous impact of CRISPR (clustered regularly interspaced short palindromic repeats), LAMP (loop-mediated isothermal amplification), cryo-EM (electron microscopy), and many other nano-techniques in the biosciences is transforming the world in so many ways, not the least of which are the diagnostic tests and vaccines that are helping our global pandemic. Microwaves are huge compared to the likes of optical wavelengths and, at least for the world of bio-spectroscopy, being able to perform and take advantage of standard microwave materials measurements at a cellular (micron) and even molecular (nanometer) scale has been a major impediment to applications for this well-developed electronics technology and instrumentation. In the early part of the 21 st Century, the fields of AFM (atomic force microscopy) and SMM (scanning microwave microscopy) came together and spun off a handful of commercial applications and instruments stimulated by some very clever engineering and bio researchers and partnerships. In this, our fourth tutorial article in our continuing series on the ubiquitous presence and applications of microwaves, we take a look at the origins, instruments, biological applications, and goals for "nano-microwaves" the use of microwaves at nanometer scales.INDEX TERMS Scanning microwave microscopy (SMM-VNA), THz near-field scattering microscopy (SMM-THz), near-field microwave imaging, near-field THz spectroscopy, nano-microwaves.This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination.

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Quantitative Scanning Microwave Microscopy of the Evolution of a Live Biological Cell in a Physiological Buffer

Cited by 23 publications

References 24 publications

Analytical expressions for spreading resistance in lossy media and their application to the calibration of scanning microwave microscopy

Analytical expressions for spreading resistance in lossy media and their application to the calibration of scanning microwave microscopy

Applications of Microwaves in Medicine

Microwaves Are Everywhere: “SMM: Nano-Microwaves”

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