Quantitative SPECT/CT—Technique and Clinical Applications

Ritt, Philipp; Kuwert, Torsten

doi:10.1007/978-3-030-42618-7_17

Cited by 13 publications

(7 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to the qualitative improvement noticed by the two consultants in this project, which is in keeping with the current literature, the introduction of SPECT-CT may lead to better sensitivity and specificity. This is especially important in interpreting DaTSCAN studies used to differentiate between different Parkinsonian syndromes [27][28][29]. Combined, these factors allowed for superior visual analysis accuracy.…”

Section: Discussionmentioning

confidence: 99%

Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

Missir

Begley

Jessop

et al. 2023

Nuclear Medicine Communications

View full text Add to dashboard Cite

Aim [123]I-Ioflupane (DaTSCAN) binds to the presynaptic dopamine transporter (DAT) and with a lower affinity to the serotonin transporter (SERT). We aimed to develop a novel method to quantify absolute uptake in the striatal (predominantly DAT binding) and extra-striatal regions (mainly SERT binding) using single-photon computed tomography-computed tomography (SPECT-CT) DaTSCAN and to improve DaTSCAN image quality. Method Twenty-six patients with Parkinsonism underwent DaTSCAN SPECT-CT prospectively. The scans were visually analyzed independently by two experienced reporters. Specific binding ratios (SBRs) from Chang attenuation corrected SPECT were obtained using GE DaTQuant. Normalized concentrations and specific uptakes (NSU) from measured attenuation and modelled scatter-corrected SPECT-CT were obtained using HERMES Hybrid Recon and Affinity and modified EARL volumes of interest. Results Striatal NSU and SBR positively correlate (R = 0.65–0.88, P = 0.00). SBR, normalized concentrations, and NSU box plots differentiated between scans without evidence of dopaminergic deficit and abnormal scans. Interestingly, body weight inversely correlated with normalized concentrations values in extra-striatal regions [frontal (R = 0.81, P = 0.00); thalamus (R = 0.58, P = 0.00); occipital (R = 0.69, P = 0.00)] and both caudate nuclei [R = 0.42, P = 0.03 (Right), R = 0.52, P = 0.01 (Left)]. Both reporters noted improved visual quality of SPECT-CT versus SPECT images for all scans. Conclusion DaTSCAN SPECT-CT resulted in more accurate quantification, improved image quality, and enabled absolute quantification of extra-striatal regions. More extensive studies are required to establish the full value of absolute quantification for diagnosis and monitoring the progression of neurodegenerative disease, to assess an interplay between DAT and SERT, and to verify serotonin and DATs are potentially DATs are dysfunctional in obesity.

show abstract

Section: Discussionmentioning

confidence: 99%

Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

Missir

Begley

Jessop

et al. 2023

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

“…However, in clinical practice, scatter window-based techniques are preferred due to their simplicity [10]. In the last 30 years, DEW and TEW scatter correction techniques have been extensively applied in SPECT imaging [10][11][12]. A number of researchers have attempted to assess these techniques for different radionuclides, collimators, SPECT systems and imaging procedures [13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Dual and Triple Energy Window Scatter Correction on I-123 Postsurgical Thyroid SPECT/CT Imaging Using a Phantom with Small Sizes of Thyroid Remnants

Michael,

Frangos,

Iakovou

et al. 2024

Life

View full text Add to dashboard Cite

I-123 is preferential over I-131 for diagnostic SPECT imaging after a thyroidectomy to determine the presence and size of residual thyroid tissue for radioiodine ablation. Scattering degrades the quality of I-123 SPECT images, primarily due to the penetration of high-energy photons into the main photopeak. The objective of this study was to quantitatively and qualitatively investigate the impact of two widely used window-based scatter correction techniques, the dual energy window (DEW) and triple energy window (TEW) techniques, in I-123 postsurgical SPECT/CT thyroid imaging using an anthropomorphic phantom with small sizes of remnants and anatomically correct surrounding structures. For this purpose, non-scatter-corrected, DEW and TEW scatter-corrected SPECT/CT acquisitions were performed for 0.5–10 mL remnants within a phantom, with 0.5–12.6 MBq administered activities within the remnants, and without and with background-to-remnant activity ratios of 5% and 10%. The decrease in photons, the noise and non-uniformity in the background region due to scatter correction were measured, as well as the signal-to-noise ratio (SNR) and the contrast-to-noise ratio (CNR) from small remnants. The images were also visually evaluated by two experienced nuclear medicine physicians. Scatter correction decreased photons to a higher extent in larger regions than smaller regions. Larger remnants yielded higher SNR and CNR values, particularly at lower background activities. It was found from the quantitative analysis and the qualitative evaluation that TEW scatter correction performed better than DEW scatter correction, particularly at higher background activities, while no significant differences were reported at lower background activities. Scatter correction should be applied in I-123 postsurgical SPECT/CT imaging to improve the image contrast and detectability of small remnants within the background.

show abstract

“…Currently, there are several bone detection systems that can determine bone quality in certain parts of the human body, including dual-photon absorptiometry (DPA) [ 16 ], single-photon absorptiometry (SPA) [ 17 ], Dual-Energy X-ray Absorptiometry (DEXA) [ 18 ] and quantitative CT (QCT) [ 19 ], which is clinically limited due to its high radiation dose, despite its high accuracy. Considering the cost of the instrument and the radiation intensity of the body, quantitative ultrasound (QUS) is one of the best methods to diagnose osteoporosis [ 20 ], which is overcome the limitations of the methods based on X-rays.…”

Section: Introductionmentioning

confidence: 99%

A Highly Flexible Piezoelectric Ultrasonic Sensor for Wearable Bone Density Testing

Song,

Wang,

Zhang

et al. 2023

Micromachines

View full text Add to dashboard Cite

Driven by the loss of bone calcium, the elderly are prone to osteoporosis, and regular routine checks on bone status are necessary, which mainly rely on bone testing equipment. Therefore, wearable real-time healthcare devices have become a research hotspot. Herein, we designed a high-performance flexible ultrasonic bone testing system using axial transmission technology based on quantitative ultrasound theory. First, a new rare-earth-element-doped PMN-PZT piezoelectric ceramic was synthesized using a solid-state reaction, and characterized by X-ray diffraction and SEM. Both a high piezoelectric coefficient d33 = 525 pC/N and electromechanical coupling factors of k33 = 0.77, kt = 0.58 and kp = 0.63 were achieved in 1%La/Sm-doped 0.17 PMN-0.47 PZ-0.36 PT ceramics. Combining a flexible PDMS substrate with an ultrasonic array, a flexible hardware circuit was designed which includes a pulse excitation module, ultrasound array module, amplification module, filter module, digital-to-analog conversion module and wireless transmission module, showing high power transfer efficiency and power intensity with values of 35% and 55.4 mW/cm2, respectively. Finally, the humerus, femur and fibula were examined by the flexible device attached to the skin, and the bone condition was displayed in real time on the mobile client, which indicates the potential clinical application of this device in the field of wearable healthcare.

show abstract

Quantitative SPECT/CT—Technique and Clinical Applications

Cited by 13 publications

References 100 publications

Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

Quantitative [123]I-Ioflupane DaTSCAN single-photon computed tomography-computed tomography in Parkinsonism

The Impact of Dual and Triple Energy Window Scatter Correction on I-123 Postsurgical Thyroid SPECT/CT Imaging Using a Phantom with Small Sizes of Thyroid Remnants

A Highly Flexible Piezoelectric Ultrasonic Sensor for Wearable Bone Density Testing

Contact Info

Product

Resources

About