Quantitative Spot-Test Analysis of Metformin in Pharmaceutical Preparations Using Ultraviolet-Visible Diffuse Reflectance Spectroscopy

Microgravimetric method for the determination of metformin in pharmaceutical preparations and in the bulk drug

“…Recently Tubino et al related an analytical quantitative method for the determination of metformin in pharmaceutical preparations and in the bulk drug using diffuse ultraviolet-visible reflectance [34].…”

Development and Validation of Stability Indicating HPLC Method for Simultaneous Determination of Antidiabetic Drugs Metformin Hydrochloride and Glyburide in Tablets

“…Few methods for the determination of metformin hydrochloride and glyburide in combined forms including HPLC and spectrophotometry [3,4] and HPTLC [5] have been reported. Metformin hydrochloride and glyburide have been determined either alone or with other active ingredients in pharmaceutical formulations using spectrophotometry [6][7][8], high-performance liquid chromatography [9][10][11][12][13][14][15][16][17], capillary electrophoresis [18,19], HPTLC [20,21] and conductometry [22]. Several methods have been described for the determination of metformin hydrochloride and glyburide either alone or with other active ingredients in biological samples using high performance liquid chromatography [9][10][11][23][24][25][26][27][28][29][30][31][32][33][34][35][36], capillary electrophoresis [37,38] and voltammetry [39].…”

Quantitative spot test analysis of soluble tannin in green tea using a portable diffuse reflectometer

“…Diffuse reflectance spectroscopy for quantitative determinations has in recent decades been combined with the spot test; this technique is simple, selective, and accurate, consistent with the reference methods. [15][16][17] Diffuse reflectance spectroscopy allows portable and low cost in situ measurements, demonstrating the versatility of the technique. 18 Matias et al 19 describe a simple and low cost lab-made reflectometer in polytetrafluoroethylene (PTFE), for colorimetric diffuse reflectance measurements.…”