Quantitative studies of the bacterial flora of the periodontium in rice rats

Socransky, S. S.; Macdonald, James B.; Sawyer, Sylvia J.; Auskaps, Aina M.

doi:10.1016/0003-9969(60)90058-3

Cited by 15 publications

(4 citation statements)

References 10 publications

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“…Rice rats, like humans, harbor Aa , one of only a few bacteria capable of longer-term infection in the oral cavity of rats (Graves et al, 2012; Socransky, Mac Donald, Sawyer, & auskaps, 1960). Aa colonizes the tooth surface, invades the gingival connective tissue, and adheres to rat buccal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

“…This animal species is not currently commercially available, requiring investigator-directed breeding and weaning. Though some evidence suggests an infectious PD etiology (Socransky et al, 1960; MacDonald, Socransky, & Sawyer, 1960; Dick, Shaw, & Socransky, 1968), the early microbiologic and molecular events surrounding rice rat PD remain undefined. Because there is currently no prospective measure to predict which individual rats will develop severe PD, rice rat PD experiments require group sizes of 13–15.…”

Section: Discussionmentioning

confidence: 99%

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Age-related periodontitis and alveolar bone loss in rice rats

Aguirre

Akhter

Neuville

et al. 2017

Archives of Oral Biology

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Objective To characterize in rice rats: (a) periodontitis (PD) progress with feeding of standard laboratory rat chow (STD) during ages 4–80 weeks; and (b) PD progress with feeding of a high sucrose-casein (H-SC) diet during young adulthood. Methods One group (N = 12) was euthanized at age 4 weeks (Baseline). Four groups (N = 8–16) consumed a STD diet from baseline and were necropsied at ages 22, 30, 52, and 80 weeks. Three groups (N= 10–16) consumed an H-SC diet from baseline. Two were necropsied at ages 22 and 30 weeks, respectively. The third switched to the STD diet at age 22 weeks and was necropsied at age 30 weeks. All mandibles/maxillae were assessed by histometry for degree of periodontal inflammation (PD Score), alveolar crest height (ACH, mm), and horizontal alveolar bone height (hABH, mm2). Results In STD diet rats aged ≥30 weeks, all endpoints were worse (P < 0.05) than at Baseline. In H-SC diet rats aged ≥22 weeks, all endpoints were worse than at Baseline (P < 0.05). At age 22 weeks, all endpoints were worse in the H-SC group than in the STD group (P < 0.05). By age 30 weeks, the STD and H-SC groups did not differ. Conclusions 1) STD diet fed rice rats develop moderate/severe PD by age 30 weeks; 2) an H-SC diet accelerates moderate/severe PD development; and 3) switching to a STD diet does not halt/reverse PD that was accelerated by an H-SC diet. These data further clarify use of the rice rat as a PD model.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Age-related periodontitis and alveolar bone loss in rice rats

Aguirre

Akhter

Neuville

et al. 2017

Archives of Oral Biology

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“…in the oral cavity of rice rats fed a HSC diet (MacDonald et al 1960). Furthermore, periodontal disease scores positively correlated with the Enterococci and Actinobacillus counts obtained from affected rice rats (Socransky et al 1960). Moreover, periodontal disease was reproduced by oral inoculation of a fecal paste or oral inoculum of four specific microorganisms from periodontitis-susceptible rice rats to periodontitis-resistant animals (Dick et al 1968; Dick and Shaw 1966).…”

Section: Discussionmentioning

confidence: 99%

Enhanced alveolar bone loss in a model of non‐invasive periodontitis in rice rats

et al. 2012

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OBJECTIVE The rice rat (Oryzomys palustris) develops periodontitis-like lesions when fed a diet high in sucrose and casein (H-SC). We aimed to establish whether this model can accurately mimic the development of human periodontitis. MATERIALS AND METHODS For this purpose, 28 day-old rice rats (15/group) were assigned to standard (STD) or H-SC diets and sacrificed after 6, 12, and 18 wks. Jaws were processed for morphometric, histometric, histologic, histomorphometric, and microCT analyses. RESULTS We found a progressive increase in horizontal alveolar bone loss (ABL) with age in maxillae of rats fed the STD diet as determined by morphometry. The H-SC diet exacerbated horizontal ABL at the palatal surface at 12 and 18 wks. Furthermore, increased vertical ABL was detected in mandibles and maxillae of rats fed the H-SC diet for 12 and/or 18 wks by histometry and microCT. Remarkably, the H-SC diet significantly increased bone remodeling at the interproximal alveolar bone of mandibles from rats fed for 6 wks, but not in those fed for longer periods. CONCLUSIONS These findings indicate that the H-SC diet induced a transient increase in alveolar bone remodeling, which is followed by ABL characteristic of moderate periodontitis.

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“…Finally, studies to characterize the bacterial flora of the rice rat in various stages of clinical disease have been performed (MacDonald, Socransky & Sawyer 1959, Socransky, MacDonald & Sawyer 1960 in an attempt to find a bacteriai agent. In these studies, whoie molars or mandibles were ground up and either examined by darkfield microscopy or plated aerobicaii)' or anaerobically.…”

Section: Discussionmentioning

confidence: 99%

Histological and ultrastructural characteristics of the periodontal syndrome in the rice rat

Ryder

1981

J of Periodontal Research

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In this paper on the periodontal syndrome in the rice rat, the effects of dietary penicillin and tetracycline on the progressive inflammatory and degenerative changes (as seen in rice rats fed diet 700 alone) were noted at the light and electron microscopic level. Throughout the observation period (0–14 weeks postweaning), animals fed diet 700 with penicillin or diet 700 with tetracycline showed no evidence of bacterial colonization, a minimal PMN infiltrate restricted to the gingival epithelium and subjacent lamina propria, and no marked degenerative changes within cells that normally inhabited the periodontium (viz. epithelial cells, fibroblasts, osteoblasts). Marked osteoblastic or osteoclastic activity was rarely noted along the alveolar crest in this group of animals. These results give added support to the concept of a single microbial agent or group of microbial agents, as the primary etiology of this disease.

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Quantitative studies of the bacterial flora of the periodontium in rice rats

Cited by 15 publications

References 10 publications

Age-related periodontitis and alveolar bone loss in rice rats

Age-related periodontitis and alveolar bone loss in rice rats

Enhanced alveolar bone loss in a model of non‐invasive periodontitis in rice rats

Histological and ultrastructural characteristics of the periodontal syndrome in the rice rat

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