Quantitative studies on serum immunoglobulin levels in suckled calves from birth to five weeks

Logan, E.F.; McBeath, DG; Lowman, B. G.

doi:10.1136/vr.94.16.367

Cited by 47 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Animals presenting adequate concentrations of passive immunoglobulins modulate the immune response by delaying the production of endogenous immunoglobulin, while those having low contents will speed up their active production as a response to environmental challenges (Husband & Lascelles, 1975;Logan et al, 1974;Ribeiro et al, 1983;Machado Neto & Packer, 1986). The decrease in IgG concentration during the first month after birth for groups 2 and 3 (Table 1; Figure 1), resulted from the catabolism of proteins passively acquired from colostrum.…”

Section: Resultsmentioning

confidence: 99%

“…For group 1, however, there was no initial peak of IgG followed by a reduction, and this can be justified by the initial condition, which determined a reduced catabolic activity and an early endogenous production of antibodies. Animals of high serum IgG contents, correlated with high concentrations of total serum protein, would delay the endogenous synthesis of immunoglobulins, while animals of low initial values would accelerate their production (Logan et al, 1974;Husband & Lascelles, 1975;Machado Neto & Packer, 1986). The serum TP and IgG variables presented similar behavior (P < 0.0001), considering the entire experimental period, with r=0.788; this was also observed by other authors (Daniele et al, 1994a;Baracat et al, 1995).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Quality of colostral passive immunity and pattern of serum protein fluctuation in newborn calves

Pauletti¹,

Neto²,

Packer³

et al. 2003

Sci. agric. (Piracicaba, Braz.)

View full text Add to dashboard Cite

Immunity acquired by newborn animals is known as passive immunity, and for ruminants, antibody acquisition depends on the ingestion and absorption of adequate amounts of immunoglobulins from colostrum. This study relates different initial levels of acquired passive protection and serum total protein (TP) and immunoglobulin G (IgG). Serum immunoglobulin concentration and total protein were evaluated for female Holstein calves in the first sixty days of life. Animals were separated into three groups according to their initial level of passive immunity: group 1-animals with a low level of passive immunity (below 20 mg mL -1 ); group 2-animals with a medium level (between 20 and 30 mg mL -1 ), and group 3-animals with a high level (above 30 mg mL -1 ). Serum total protein was determined through the biuret method and IgG was determined by radial immunodiffusion. Data were analyzed as a completely randomized, split-plot statistical design. Fluctuation of the variables along the experimental period was determined through non-linear regression by the DUD method (PROC NLIN -Non Linear SAS). Animals with low antibody acquisition started to produce antibodies earlier, reflecting a compensatory synthesis. On the other hand, animals having adequate levels exhibited an extended period of immunoglobulin catabolism and the beginning of the endogenous phase was delayed. Regardless initial levels, the fluctuations in IgG contents occurred around adequate physiological concentrations, ranging from 20 to 25 mg mL -1 .

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Quality of colostral passive immunity and pattern of serum protein fluctuation in newborn calves

Pauletti¹,

Neto²,

Packer³

et al. 2003

Sci. agric. (Piracicaba, Braz.)

View full text Add to dashboard Cite

show abstract

“…Colostral immunoglobulins (Ig) are rapidly resorbed by calves, resulting in a rapid increase of serum concentrations within the first 24 h p.n. (33). Individual variations in the titer dynamics may result from variations in the time of onset of gut closure.…”

Section: Discussionmentioning

confidence: 99%

Maternally and Naturally Acquired Antibodies to Shiga Toxins in a Cohort of Calves Shedding Shiga-Toxigenic Escherichia coli

Fröhlich

Baljer

Menge

2009

Appl Environ Microbiol

View full text Add to dashboard Cite

Calves become infected with Shiga toxin-producing Escherichia coli (STEC) early in life, which frequently results in long-term shedding of the zoonotic pathogen. Little is known about the animals' immunological status at the time of infection. We assessed the quantity and dynamics of maternal and acquired antibodies to Shiga toxins (Stx1 and Stx2), the principal STEC virulence factors, in a cohort of 27 calves. Fecal and serum samples were taken repeatedly from birth until the 24th week of age. Sera, milk, and colostrums of dams were also assessed. STEC shedding was confirmed by detection of stx in fecal cultures. Stx1-and Stx2-specific antibodies were quantified by Vero cell neutralization assay and further analyzed by immunoblotting. By the eighth week of age, 13 and 15 calves had at least one stx 1 -type and at least one stx 2 -type positive culture, respectively. Eleven calves had first positive cultures only past that age. Sera and colostrums of all dams and postcolostral sera of all newborn calves contained Stx1-specific antibodies. Calf serum titers decreased rapidly within the first 6 weeks of age. Only five calves showed Stx1-specific seroconversion. Maternal and acquired Stx1-specific antibodies were mainly directed against the StxA1 subunit. Sparse Stx2-specific titers were detectable in sera and colostrums of three dams and in postcolostral sera of their calves. None of the calves developed Stx2-specific seroconversion. The results indicate that under natural conditions of exposure, first STEC infections frequently coincide with an absence of maternal and acquired Stx-specific antibodies in the animals' sera.

show abstract

“…This seems to coincide with the time when the passive immunity provided by colostral antibodies is decreased (Fig. 4), and the calf's own Ig production has not yet reached the full capacity (Logan et al 1974 b, Husband and Lascelles 1975). Therefore, at this particular period, the salivary LF could contribute to a greater extent to the defence mechanisms of the calf.…”

Section: Discussionmentioning

confidence: 99%

“…The subsequent significant increase in the levels of all Ig classes, except for IgG 2 , can be explained by the activation of the calf's own immune system. Depending on the duration of feeding of colostrum and amount of antibodies in it, the active intestinal synthesis of Ig may commence already within the first week of life (Logan et al 1974b, Husband and Lascelles 1975, Porter et al 1977. Also in the saliva, Ig (mainly secretory IgA) is present at one week of age but not at birth (Mach and Pahudl97l, Butler et al 1972).…”

Section: Discussionmentioning

confidence: 99%

Xylitol, polyol molasses and glucose in the diet of newborn calves: II. Content of antimicrobial factors in blood and saliva, bacteria in faeces and health status

Korhonen

Alasaari

Antila

1984

AFSci

View full text Add to dashboard Cite

Abstract. The concentrations of various antimicrobial factors in the saliva and plasma of newborn calves with special reference to possible effects of a diet supplemented with different sugar alcohols were studied. Eighteen calves were assigned alternately at birth to three groups, each comprising six animals. All calves were fed a pooled colostrum diet for the first four days, thereafter whole milk plus milk replacer. Concentrates and hay were given ad libitum. The diets of the different groups were supplemented with the following test substrates: xylitol, polyol molasses or glucose (control). The daily doses of each substrate were progressively increased from 0.5 to 1.0 g/kg of live weight for the last four weeks. Plasma and saliva samples were taken from all calves before colostrum feeding (day 0) and on days 1,2, 4,7, 21 and 35 after birth. The following factors were determined quantitatively: lactoferrin (LF), lactoperoxidase (LP), lysozyme (LZM) and immunoglobulins IgG,, lgG 2 , IgM and IgA (only in plasma).Further determinations included weekly counts of total aerobic bacteria, aerobic haemolytic bacteria, coliforms, lactobacilli and clostridia in faeces.Salivary LF increased from the average 0 day level of 3.6 -17.0 /rg/ml in the different groups to a maximum of 38.7 -55.6 jig/ml within one week, and declining thereafter slowly in all groups. LF was not found in the saliva of all calves at birth, but was consistently present later on. No LF was detected in plasma. Salivary LP increased from the average 0 day level of 56.3 -86.6 /rg/ml in the different groups to a maximum of 228-296 /j.g/ml within three weeks and declined markedly by day 35. LP was found in all saliva samples, but the plasma concentrations were very low and not always detectable. Salivary LZM was high at birth compared to the plasma level (average 0.8-2.1 /rg/ml vs. 0.3 -0.5 ng/ml in the different groups)Present address: Ministry of Livestock Development,

show abstract

Quantitative studies on serum immunoglobulin levels in suckled calves from birth to five weeks

Cited by 47 publications

References 0 publications

Quality of colostral passive immunity and pattern of serum protein fluctuation in newborn calves

Quality of colostral passive immunity and pattern of serum protein fluctuation in newborn calves

Maternally and Naturally Acquired Antibodies to Shiga Toxins in a Cohort of Calves Shedding Shiga-Toxigenic Escherichia coli

Xylitol, polyol molasses and glucose in the diet of newborn calves: II. Content of antimicrobial factors in blood and saliva, bacteria in faeces and health status

Contact Info

Product

Resources

About