2016
DOI: 10.1186/s12953-016-0092-y
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Quantitative succinylome analysis in the liver of non-alcoholic fatty liver disease rat model

Abstract: BackgroundNon-alcoholic fatty liver disease (NAFLD) is a clinical frequent disease. However, its pathogenesis still needs further study, especially the mechanism at the molecular level. The recent identified novel protein post-translational modification, lysine succinylation was reported involved in diverse metabolism and cellular processes. In this study, we performed the quantitative succinylome analysis in the liver of NAFLD model to elucidate the regulatory role of lysine succinylation in NAFLD progression… Show more

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Cited by 38 publications
(25 citation statements)
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“…In our study, succinylated lysine residues were more frequently located on α-helix, and less frequently located on β-strand and coil, as compared with all lysine residues. The similar preferences were observed in rat that the succinylated lysine residues were moderately biased occurring on α-helix, and moderate biased against on β-strand and coil regions [ 33 ]. Furthermore, the succinylated sites tended to be exposed on the protein surface, as compared with all lysine residues.…”
Section: Resultssupporting
confidence: 64%
“…In our study, succinylated lysine residues were more frequently located on α-helix, and less frequently located on β-strand and coil, as compared with all lysine residues. The similar preferences were observed in rat that the succinylated lysine residues were moderately biased occurring on α-helix, and moderate biased against on β-strand and coil regions [ 33 ]. Furthermore, the succinylated sites tended to be exposed on the protein surface, as compared with all lysine residues.…”
Section: Resultssupporting
confidence: 64%
“…Several global omics‐based studies have addressed the molecular aspects of fatty liver development in diet‐induced obese rodent models and diabetic mice (Baiges et al., ; Xie et al., ; Zhang et al. ; Bondia‐Pons et al., ; Kirpich et al., ; Oh et al., ; Rubio‐Aliaga et al., ; Almon et al., ; Midha et al., ; Kim et al., ; Benard et al., ; Cheng et al., ). This led to an emerging interest in the role of mitochondria in NAFLD and nonalcoholic steatohepatitis (Guo et al., ; Thomas et al., ; Li et al., ; Nesteruk et al., ).…”
Section: Introductionmentioning
confidence: 99%
“…The development of NAFLD has been frequently studied in animal models exposed to high fat diets (Begriche et al 2013;Kakimoto and Kowaltowski 2016). Several global omics-based studies have addressed the molecular aspects of fatty liver development in dietinduced obese rodent models and diabetic mice (Baiges et al, 2010;Xie et al, 2010;Zhang et al 2010;Bondia-Pons et al, 2011;Kirpich et al, 2011;Oh et al, 2011;Rubio-Aliaga et al, 2011;Almon et al, 2012;Midha et al, 2012;Kim et al, 2013;Benard et al, 2016;Cheng et al, 2016). This led to an emerging interest in the role of mitochondria in NAFLD and nonalcoholic steatohepatitis (Guo et al, 2013;Thomas et al, 2013;Li et al, 2014;Nesteruk et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…Second, the effect of various genetic variants has not been incorporated into the model at this first step. Third, our current model considers largely transcriptional factors, while both microRNA regulation [82] and post-translational modifications [83] of proteins have been shown to be important in the context of NAFLD. Despite these limitations, this analysis strongly suggests the role of phenotypic plasticity in the development and progression of NAFLD.…”
Section: Discussionmentioning
confidence: 99%