Quantitative susceptibility mapping of the normal-appearing white matter as a potential new marker of disability progression in multiple sclerosis

Quantitative susceptibility mapping in multiple sclerosis: A systematic review and meta-analysis

“…Abbreviations: Assoc = association, NAWM = normal-appearing white matter, NAGM = normal-appearing grey matter. Clinical and demographical variables in relation to QSM variables Studies with significant results Studies without significant results Proportion of significant findings (%) Reference Assoc Reference Expanded Disease Status Scale Lesion frequency Castellaro et al (2017) + Guo et al (2021) 2/5 (40 %) Tolaymat et al (2020) Haacke et al (2021) Pelizzari et al (2020) Lesion QSM values Coffman et al (2022) + Guo et al (2021) 1/3 (33 %) Harrison et al (2016) Rim lesion frequency Huang et al (2022) + Cronin et al (2016) 4/7 (57 %) Marcille et al (2022) Jang et al (2020) Coffman et al (2022) Yao et al (2018) Tolaymat et al (2020) NAWM QSM values Pietroboni et al (2022) + Pontillo et al (2023) 1/3 (33 %) Hamdy et al (2022) Neurological Assessments Lesion frequency Harrison et al (2016) 0/1 (0 %) Lesion QSM values Harrison et al (2016) 0/1 (0 %) …”

“… 1/1 (100 %) Rim lesion frequency Harrison et al (2016) n.a. 1/1 (100 %) QSM lesion volume Pelizzari et al (2020) 0/2 (0 %) Tolaymat et al (2020) NAWM QSM values Pietroboni et al (2022) n.a. 1/1 (100 %) …”