Quantitative ultrasonography in rheumatoid arthritis: evaluation of inflammation by Doppler technique

Qvistgaard, Étienne; Røgind, Henrik; Torp‐Pedersen, Søren; Terslev, Lene; Danneskiold‐Samsøe, Bente; Bliddal, Henning

doi:10.1136/ard.60.7.690

Cited by 188 publications

(138 citation statements)

References 11 publications

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“…Quantitative approaches are also utilized, including the determination of the number of Doppler pixels by dedicated pixel-counting software 12,13,14,15 , measurement of pulsatility and resistive indices, and microbubble contrast material.…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

“…Therefore, the number of joints that need to be assessed, and thus incorporated into any global ultrasound scoring system, is an important issue. Propositions on the number and composition of reduced joint counts were based either on suggested frequency of involvement 14,25,30 or representative value of target joints 9,31,36 ; or they were developed in a logistic regression model 26 . Validation of proposed joint scores was quite often omitted, and only 2 papers examined the metric properties of the proposed reduced joint score 25,26 .…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

“…Of 3004 studies identified initially, 14 articles were selected to be included in the review 8,9,14,25,26,27,28,29,30,31,32,33,34,35 . Table 1 shows the study design characteristics of the studies.…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

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A Systematic Literature Review Analysis of Ultrasound Joint Count and Scoring Systems to Assess Synovitis in Rheumatoid Arthritis According to the OMERACT Filter

Mandl

Naredo²,

Wakefield³

et al. 2011

J Rheumatol

186

110

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Objective. The OMERACT Ultrasound Task Force is currently developing a global synovitis score (GLOSS) with the objective of feasibly measuring global disease activity in patients with rheumatoid arthritis (RA). In order to determine the minimal number of joints to be included in such a scoring system, and to analyze the metric properties of proposed global (i.e., patient level) ultrasound (US) scoring systems of synovitis in RA, a systematic analysis of the literature was performed. Methods. A systematic literature search of Pubmecl and Embase was performed (January 1, 1984, to March 31, 2010). Original research reports written in English including RA, ultrasound, Doppler, and scoring systems were included. The design, subjects, methods, imaging protocols, and performance characteristics studied were analyzed, as well as the ultrasound definition of synovitis. Results. Of 3004 reports identified, 14 articles were included in the review. We found a lack of clear definition of synovitis as well as varying validity data with respect to the proposed scores. Scoring systems included a wide range and number of joints. All analyzed studies assessed construct validity and responsiveness by using clinical examination, laboratory findings, and other imaging modalities as comparators. Both construct validity and responsiveness varied according to the number and size of joints examined and according to the component of synovitis measured [i.e., gray-scale (GS) or power Doppler (PD) alone or in combination]. With regard to feasibility, time of evaluation varied from 15 to 60 min and increased with the number of joints involved in the examination. Conclusions. Ultrasound can be regarded as a valuable tool for globally examining the extent of synovitis in RA. However, it is presently difficult to determine a minimal number of joints to be included in a global ultrasound score. Further validation of proposed scores is needed. (J Rheumatol 2011; 38:2055-62; doi:10.3899/jrheum.110424

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Section: Journal Of Rheumatologymentioning

confidence: 99%

Section: Journal Of Rheumatologymentioning

confidence: 99%

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A Systematic Literature Review Analysis of Ultrasound Joint Count and Scoring Systems to Assess Synovitis in Rheumatoid Arthritis According to the OMERACT Filter

Mandl

Naredo²,

Wakefield³

et al. 2011

J Rheumatol

186

110

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“…This method has been used to assess soft-tissue vascularity and treatment efficacy with a variety of musculoskeletal and related problems. Changes in vascularity in synovial tissues in patients with rheumatoid arthritis [8][9][10][11], osteoarthritis [12,13], tendinopathy [6,[14][15][16][17][18][19][20][21] and plantar fasciitis [6] have been reported. Modulation in vascularity was observed in patients with tendinopathy after a course of intervention [14][15][16][17][18][19][20][21].…”

mentioning

confidence: 99%

“…Tissue vascularity was quantified by computing a vascular index (VI), which is calculated as the ratio of the number of colour pixels to the total number of pixels within the region of interest in patients with soft-tissue problems [8,9,11,17]. Note that most of these studies were conducted using colour Doppler ultrasonography.…”

mentioning

confidence: 99%

Correlation between computerised findings and Newman's scaling on vascularity using power Doppler ultrasonography imaging and its predictive value in patients with plantar fasciitis

Chen

Ho²,

Ying³

et al. 2012

BJR

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Objectives: The purpose of this study was to correlate findings on small vessel vascularity between computerised findings and Newman's scaling using power Doppler ultrasonography (PDU) imaging and its predictive value in patients with plantar fasciitis. Methods: PDU was performed on 44 patients (age range 30-66 years; mean age 48 years) with plantar fasciitis and 46 healthy subjects (age range 18-61 years; mean age 36 years). The vascularity was quantified using ultrasound images by a customised software program and graded by Newman's grading scale. Vascular index (VI) was calculated from the software program as the ratio of the number of colour pixels to the total number of pixels within a standardised selected area of proximal plantar fascia. The 46 healthy subjects were examined on 2 occasions 7-10 days apart, and 18 of them were assessed by 2 examiners. Statistical analyses were performed using intraclass correlation coefficient and linear regression analysis. Results: Good correlation was found between the averaged VI ratios and Newman's qualitative scale (r50.70; p,0.001). Intratester and intertester reliability were 0.89 and 0.61, respectively. Furthermore, higher VI was correlated with less reduction in pain after physiotherapeutic intervention. Conclusions: The computerised VI not only has a high level of concordance with the Newman grading scale but is also reliable in reflecting the vascularity of proximal plantar fascia, and can predict pain reduction after intervention. This index can be used to characterise the changes in vascularity of patients with plantar fasciitis, and it may also be helpful for evaluating treatment and monitoring the progress after intervention in future studies.

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Reliability of ultrasonography to detect synovitis in rheumatoid arthritis: A systematic literature review of 35 studies (1,415 patients)

Cheung

Dougados

Gossec

2010

Arthritis Care & Research

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Objective. To perform a systematic review on the reliability of ultrasonographic (US) synovitis detection in rheumatoid arthritis (RA) by B-mode and power Doppler (PD) in image acquisition and still-image interpretation. US is a sensitive method for synovitis detection. However, reliability is still a key concern. Methods. Articles reporting any US reliability results for synovitis in RA in PubMed, EMBase, the Cochrane Library, and meeting abstracts were selected. Data were extracted from the collection of data on US synovitis detection (either qualitatively [binary] or semiquantitatively [0 -3 scale], for intraobserver and interobserver reliability in B-mode and PD, and for image acquisition and still-image interpretation). The type of joints tested, the experience of the ultrasonographer, and the quality of the studies were assessed. Data analysis involved descriptive and graphic interpretation of reliability and its potential determinants. Conclusion. Intraobserver and interobserver reliability of still-image interpretation was high, especially for PD, in published studies involving highly trained observers. However, reliability of acquisition of US should be further assessed.

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Quantitative ultrasonography in rheumatoid arthritis: evaluation of inflammation by Doppler technique

Cited by 188 publications

References 11 publications

A Systematic Literature Review Analysis of Ultrasound Joint Count and Scoring Systems to Assess Synovitis in Rheumatoid Arthritis According to the OMERACT Filter

A Systematic Literature Review Analysis of Ultrasound Joint Count and Scoring Systems to Assess Synovitis in Rheumatoid Arthritis According to the OMERACT Filter

Correlation between computerised findings and Newman's scaling on vascularity using power Doppler ultrasonography imaging and its predictive value in patients with plantar fasciitis

Reliability of ultrasonography to detect synovitis in rheumatoid arthritis: A systematic literature review of 35 studies (1,415 patients)

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