Quantitative ultrasound at the hand phalanges: comparison with quantitative computed tomography of the lumbar spine in postmenopausal women

Feltrin, Giampietro; Nardin, Marco De; Marangon, Alessandro; Khadivi, Yeganeh; Calderone, Milena; Conti, Giorgio

doi:10.1007/s003300051013

Cited by 8 publications

(9 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since we were assessing bone density in healthy young subjects we chose a radiation-free approach, the validity of which has been demonstrated by several studies showing good correlation with dual X-ray absorptiometry in various locations and quantitative computer tomography (QCT) of the spine (Alenfeld et al, 1998;Goerres et al, 1998;Wu Èster et al, 1998;Fiore et al, 1999;Guglielmi et al, 1999;Przedlacki et al, 1999;Feltrin et al, 2000). We used a DBM BP sonic 1200 apparatus (IGEA, Sensweiler, Germany) to determine the amplitude-dependent speed of sound (AdSoS) of the digits II± V of the dominant hand; this is a quantitative ultrasound (QUS) device that does not measure bone ultrasound attenuation.…”

Section: Phalangeal Ultrasoundmentioning

confidence: 99%

The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males

Zitzmann

Brune

Kornmann

et al. 2001

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

Section: Phalangeal Ultrasoundmentioning

confidence: 99%

The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males

Zitzmann

Brune

Kornmann

et al. 2001

Clinical Endocrinology

View full text Add to dashboard Cite

show abstract

“…Moreover, it has been reported that phalangeal AD-SoS presents a faster rate of decrease than calcaneal for changes related to both age and time since menopause. Finally, phalanges are skeletal segments easily accessible to measurement with QUS [15,16]. BMI represents one of the main determinants of bone mineral density [17] and a close positive relationship between body size and bone mass has been demonstrated repeatedly [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of skeletal status by quantitative ultrasonometry in postmenopausal women without known risk factors for osteoporosis

Mandato

Sammartino

Carlo

et al. 2005

Gynecological Endocrinology

View full text Add to dashboard Cite

The objective of our study was to evaluate bone density in Italian postmenopausal women without clinical risk factors for osteoporosis resident in the Naples area using quantitative ultrasonometry of bone (QUS). Subjects were 1149 Italian postmenopausal women (age: 54.9 +/- 5.0 years (mean +/- standard deviation); range: 45-74 years) resident in the Naples area. Clinical risk factors for osteoporosis resulting in exclusion from the study were family history of osteoporosis, dietary, smoking and alcohol habits, personal history of fractures and/or metabolic diseases. The following QUS parameters were calculated: amplitude-dependent speed of sound (AD-SoS), T-score and Z-score. We found significant inverse correlations between AD-SoS and age (r = - 0.23), time since menopause (r = - 0.25) and body mass index (BMI) (r = - 0.16). The same was observed for T-score. In contrast, Z-score showed a significant positive correlation with age and time since menopause, and a negative correlation with BMI. A T-score suggestive of high risk for osteoporosis (less than -3.2) was found in 1.6% of subjects, while a T-score suggestive of moderate risk for osteoporosis (between -3.2 and -2) was found in 19.3% of patients. In this group of women without clinical risk factors for osteoporosis we found a very low prevalence of QUS results suggesting a high risk for osteoporosis. However, a condition of 'moderate' risk for osteoporosis was present in a remarkable percentage of these women.

show abstract

“…Results were expressed as SDS with respect to sex-and age-matched healthy subjects 15 . Amplitude dependent speed of sound (Ad-SoS) and Ultrasound Bone Profile Index (UBPI) were measured by DBM Sonic, IGEA, Italy.…”

Section: Bone Mineral Densitometrymentioning

confidence: 99%

Persistence of Delayed Adrenarche in Boys with Thalassemia

Filosa¹,

Maio²,

Esposito³

et al. 2001

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

5 years after a previous study, we followed up a group of thalassemic patients, determining DHEA-S levels in peripubertal age, with the aim of evaluating whether adrenarche maturation occurred in boys and advanced in girls. Furthermore, we evaluated the degree of bone mineral density (BMD SDS(BA)) and analyzed growth parameters calculating standard deviation score with respect to bone age (BA) of height (Ht SDS(BA)), sitting height (SH SDSBA), and subischial leg length (SLL SDSBA), body mass index (BMI) and the difference between the values of the previous and the present study (deltaBMI), thyroid function and serum markers of bone metabolism. Our results showed persistent lack of adrenarche (DHEA-S 25+/-9.5 microg/dl) in all 6 boys and the absence of pubertal signs at chronological age (CA) of 12.4+/-1.4 yr and BA of 11.1+/-1.1 yr. Only one boy, 6 months later, showed a testicular volume of 4 ml (Tanner stage G2) with an increase of DHEA-S value (181 microg/dl) at BA 12.8 yr. Body disproportion and severe degree of osteopenia (BMD SDSBA -2.41+/-0.5) were observed in all boys, even though Ht SDSBA (0.14+/-0.8) and markers of bone metabolism were within the normal range. No change in nutritional status was observed (deltaBMI 0.09+/-0.4 kg/m2). In contrast, all the thalassemic girls had DHEA-S values (172.7+/-97.7 microg/dl) within the normal range at BA 12.7 +/-0.6 yr that was similar to CA. Furthermore, the appearance of Tanner stage B2 occurred in each of them at BA, near to CA, of 10.4+/-0.9 yr, and menarche was observed in three of them at mean BA, near to CA, of 11.4+/-0.9 yr. Ht SDSBA was below normal range (-1.11+/-0.8), but SLL SDSBA and SH SDS(BA) values were reduced homogeneously, so that proportional body growth was observed. A significant change in nutritional status was observed (deltaBMI 2.69+/-0.9 kg/m2). Bone density value (BMD SDS(BA) -0.25+/-0.4) was in the normal range. There were no statistically significant differences between boys and girls for ferritin serum levels, blood consumption and desferrioxamine dosage. In conclusion, lack of change in nutritional status, measurable in the form of deltaBMI, but not BMI alone, considered an important physiological regulator of adrenarche, regardless of individual adrenal androgen secretion, could have a key role in the lack of adrenarche persisting in thalassemic boys during peripubertal age. Further follow up is necessary, in particular when boys reach puberty, because delayed adrenarche represents the most intriguing aspect in these patients.

show abstract

Quantitative ultrasound at the hand phalanges: comparison with quantitative computed tomography of the lumbar spine in postmenopausal women

Cited by 8 publications

References 29 publications

The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males

The CAG repeat polymorphism in the androgen receptor gene affects bone density and bone metabolism in healthy males

Evaluation of skeletal status by quantitative ultrasonometry in postmenopausal women without known risk factors for osteoporosis

Persistence of Delayed Adrenarche in Boys with Thalassemia

Contact Info

Product

Resources

About