Quantitative volumetric functional MR imaging: an imaging biomarker of early treatment response in hypo-vascular liver metastasis patients after yttrium-90 transarterial radioembolization

Zhu, Xiangyu; Sobhani, Fatemeh; Xu, Can; Pan, Li; Ghasebeh, Mounes Aliyari; Kamel, Ihab R.

doi:10.1007/s00261-016-0694-y

Cited by 12 publications

(2 citation statements)

References 28 publications

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“…They concluded that RECIST, mRECIST, and EASL were inadequate in the assessment of post-TARE imaging of hypovascular liver metastasis. They suggested that a quantitative volumetric functional MRI should be performed in future research and clinical trials, because it may predict outcomes earlier than the currently used criteria [ 23 ]. Sobhani et al reported similar conclusions in a retrospective study of 17 patients who underwent transarterial chemoembolization (TACE), a similar embolizing therapy that uses chemotherapy drugs and microspheres as opposed to irradiated microspheres.…”

Section: Reviewmentioning

confidence: 99%

Assessment of Treatment Response Following Yttrium-90 Transarterial Radioembolization of Liver Malignancies

Adcock¹,

Florez²,

Zand³

et al. 2018

Cureus

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Transarterial radioembolization using yttrium-90 microspheres is an established and effective treatment for liver malignancies. Determining response to this treatment is difficult due to the radical changes that occur in tissue as a response to radiation. Though accurate assessment of treatment response is paramount for proper patient disposition, there is currently no standardized assessment protocol. Current methods of assessment often consider changes in size, necrosis, vascularity, fluorodeoxyglucose-positron emission tomography FDG-PET metabolic activity, and diffusion using diffusion-weighted magnetic resonance imaging (DWI). Current methods of assessment require a lag time of one to two months post-treatment to determine treatment effectiveness. This delay is a hindrance to obtaining better patient outcomes, giving rise to a need to identify markers for faster determination of treatment efficacy.

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Section: Reviewmentioning

confidence: 99%

Assessment of Treatment Response Following Yttrium-90 Transarterial Radioembolization of Liver Malignancies

Adcock¹,

Florez²,

Zand³

et al. 2018

Cureus

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“…Ideally, the minimum threshold for high liver function should be identified based on the immediate and long-term dose–response of the functional MRI parameter. Previous studies have reported on longitudinal changes in DWI and DCE-MRI parameters in liver cancer tumours following treatments such as chemotherapy, chemo-embolisation and radio-embolisation [ 123 , 124 , 125 ]. However, liver SBRT is a relatively new treatment and there is insufficient data on the radiation dose response of these parameters in tumours and the non-tumour cirrhosis-affected liver.…”

Section: Discussionmentioning

confidence: 99%

Role of Functional MRI in Liver SBRT: Current Use and Future Directions

Tadimalla

Wang

Haworth

2022

Cancers

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Stereotactic body radiation therapy (SBRT) is an emerging treatment for liver cancers whereby large doses of radiation can be delivered precisely to target lesions in 3–5 fractions. The target dose is limited by the dose that can be safely delivered to the non-tumour liver, which depends on the baseline liver functional reserve. Current liver SBRT guidelines assume uniform liver function in the non-tumour liver. However, the assumption of uniform liver function is false in liver disease due to the presence of cirrhosis, damage due to previous chemo- or ablative therapies or irradiation, and fatty liver disease. Anatomical information from magnetic resonance imaging (MRI) is increasingly being used for SBRT planning. While its current use is limited to the identification of target location and size, functional MRI techniques also offer the ability to quantify and spatially map liver tissue microstructure and function. This review summarises and discusses the advantages offered by functional MRI methods for SBRT treatment planning and the potential for adaptive SBRT workflows.

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Response Assessment by Volumetric Iodine Uptake Measurement: Preliminary Experience in Patients with Intermediate-Advanced Hepatocellular Carcinoma Treated with Yttrium-90 Radioembolization

Bargellini¹,

Crocetti²,

Turini³

et al. 2018

Cardiovasc Intervent Radiol

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Quantitative volumetric functional MR imaging: an imaging biomarker of early treatment response in hypo-vascular liver metastasis patients after yttrium-90 transarterial radioembolization

Cited by 12 publications

References 28 publications

Assessment of Treatment Response Following Yttrium-90 Transarterial Radioembolization of Liver Malignancies

Assessment of Treatment Response Following Yttrium-90 Transarterial Radioembolization of Liver Malignancies

Role of Functional MRI in Liver SBRT: Current Use and Future Directions

Response Assessment by Volumetric Iodine Uptake Measurement: Preliminary Experience in Patients with Intermediate-Advanced Hepatocellular Carcinoma Treated with Yttrium-90 Radioembolization

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