Quantitative Volumetry of Cement Leakage in Viscosity-controlled Vertebroplasty

Gstöttner, Michaela; Angerer, Alexandra; Rosiek, R.; Bach, Christian

doi:10.1097/bsd.0b013e31823f62b1

Cited by 23 publications

(10 citation statements)

References 14 publications

(20 reference statements)

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“…One factor influencing cement leakage is the cement viscosity. 27 Gstöttner et al studied 37 patients (76 operated vertebrae) who had viscosity-controlled vertebroplasty and compared the results with a retrospective group of 31 patients (35 operated vertebrae) undergoing vertebroplasty without using a viscosimeter. They found that use of viscosity-controlled vertebroplasty led to a decrease in the leakage rate from 58.3 to 42.1% without any significant difference in the volume of the injected cement based on the imaging measurements.…”

Section: Discussionmentioning

confidence: 99%

“…They found that use of viscosity-controlled vertebroplasty led to a decrease in the leakage rate from 58.3 to 42.1% without any significant difference in the volume of the injected cement based on the imaging measurements. 27 One limitation of the study is that the researchers compared a retrospective group to a prospective group of patients. One might expect that the additional experience gained in the viscosity-controlled vertebroplasty might also have contributed to the lower cement leakage rate.…”

Section: Discussionmentioning

confidence: 99%

“… 14 Some studies showed that the cement viscosity has also been identified to be an important factor in decreasing cement leakage, implying that high-viscosity cements can cause decreased cement leakage. 12 15 27 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does Balloon Kyphoplasty Deliver More Cement Safely into Osteoporotic Vertebrae with Compression Fractures Compared with Vertebroplasty? A Study in Vertebral Analogues

Abduljabbar

Aljurayyan

Al-Qahtani

et al. 2015

Global Spine Journal

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Study Design A biomechanical and radiographic study using vertebral analogues. Objectives Kyphoplasty and vertebroplasty are widely used techniques to alleviate pain in fractures secondary to osteoporosis. However, cement leakage toward vital structures like the spinal cord can be a major source of morbidity and even mortality. We define safe cement injection as the volume of the cement injected into a vertebra before the cement leakage occurs. Our objective is to compare the amount of cement that can be safely injected into an osteoporotic vertebra with simulated compression fracture using either vertebroplasty or balloon kyphoplasty techniques. Methods Forty artificial vertebral analogues made of polyurethane with osteoporotic cancellous matrix representing the L3 vertebrae were used for this study and were divided into four groups of 10 vertebrae each. The four groups tested were: low-viscosity cement injected using vertebroplasty, high-viscosity cement injected using vertebroplasty, low-viscosity cement injected using balloon kyphoplasty, and high-viscosity cement injected using balloon kyphoplasty. The procedures were performed under fluoroscopic guidance. The injection was stopped when the cement started protruding from the created vascular channel in the osteoporotic vertebral fracture model. The main outcome measured was the volume of the cement injected safely into a vertebra before leakage through the posterior vascular channel. Results The highest volume of the cement injected was in the vertebroplasty group using high-viscosity cement, which was almost twice the injected volume in the other three groups. One-way analysis of variance comparing the four groups showed a statistically significant difference (p < 0.005). Conclusions High-viscosity cement injected using vertebroplasty delivers more cement volume before cement leakage and fills the vertebral body more uniformly when compared with balloon kyphoplasty in osteoporotic vertebrae with compression fractures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Does Balloon Kyphoplasty Deliver More Cement Safely into Osteoporotic Vertebrae with Compression Fractures Compared with Vertebroplasty? A Study in Vertebral Analogues

Abduljabbar

Aljurayyan

Al-Qahtani

et al. 2015

Global Spine Journal

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“…Beş vertebrada kanül trasesine kaçak (%19.2) izlenmiş olup bu oran önceki çalışmalara bakıldığında yüksek görünmektedir (25) ancak bu komplikasyonun yapılan ilk 8 hastada meydana gelmesi ve daha sonraki vakalarda izlenmemesinde çimento viskositesinin ve miktarının daha uygun seçiminin rol aldığı düşünüldü (32,33).Bu bulguya dayanılarak daha önceki çalışmalarda da görüldüğü gibi işlem için cerrahi öğrenim sürecinin önemli olduğu düşünüldü. Bunun yanında kullanılan kemik çimento akışkanlığını operasyon odasının sıcaklığı ve neminin, karıştırma şekli ve süresinin etkilediği akılda bulundurmak gerekmektedir.…”

Section: Gereç Ve Yöntemunclassified

Perkutan Transpedikuler Vertebroplastide Kemik Cimento Kacagi: Yirmi Hastanin Analizi

2018

GMJ

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“…Ovarian cancer accounts for approximately 5% of female malignant tumors [1]. In China, the incidence ranks third in all female malignant tumors and it has a gradually increasing trend in recent years [2].…”

mentioning

confidence: 99%

Effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells

Cong

Liu

Hou

et al. 2019

neo

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This study investigates the effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells. Epithelial ovarian cancer tissues were collected from 60 patients, benign ovarian tissues from 45 patients and normal ovarian tissues from 30 patients. Human epidermal growth factor receptor 2 (HER2) protein expression was measured by immunohistochemistry and mRNA expression by quantitative real-time polymerase chain reaction (RT-PCR). Proliferation and apoptosis of SKOV3 cells were then measured by MTS assay and flow cytometry and cleaved caspase-3 expression was detected by Western blot. Our results established that HER2 protein is expressed in tumor tissues, benign tissues and normal tissues and its positive expression rate in tumor tissues is significantly higher than in benign tissues and normal tissues (p<0.05). In addition, the relative HER2 mRNA expression in epithelial ovarian tumor tissues was 55 times higher than that in normal ovarian tissues (p<0.01). Our research confirmed that trastuzumab significantly inhibited SKOV3 cell proliferation and increased cell apoptosis and cleaved caspase-3 expression in the experimental group compared to controls (p<0.05). In conclusion, HER2 protein is over-expressed in epithelial ovarian cancer tissues, and trastuzumab exerts anti-tumor effect by inhibiting cell proliferation and inducing apoptosis, suggesting it might be a novel approach for the treatment of ovarian cancer.

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Quantitative Volumetry of Cement Leakage in Viscosity-controlled Vertebroplasty

Cited by 23 publications

References 14 publications

Does Balloon Kyphoplasty Deliver More Cement Safely into Osteoporotic Vertebrae with Compression Fractures Compared with Vertebroplasty? A Study in Vertebral Analogues

Does Balloon Kyphoplasty Deliver More Cement Safely into Osteoporotic Vertebrae with Compression Fractures Compared with Vertebroplasty? A Study in Vertebral Analogues

Perkutan Transpedikuler Vertebroplastide Kemik Cimento Kacagi: Yirmi Hastanin Analizi

Effects of trastuzumab on the proliferation and apoptosis of ovarian cancer cells

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