Located at an average elevation of approximately 2000 m, the Minjiang River Basin (MJB), a key tributary of the Upper Yangtze River, straddles the Western Sichuan Plateau and the Sichuan Basin. Vegetation here is crucial for human life, providing oxygen and energy. However, the influence of climatic variables, human activities, and rugged terrain on vegetation vitality is still debated. This study mainly leverages data from the Normalized Difference Vegetation Index (NDVI), meteorological stations data, and land use data. Analytical techniques include trend analysis, partial correlation coefficient analysis (PCC), principal component analysis (PCA), and partial least squares structural equation modeling (PLS-SEM). Results indicate a stable upward trend in vegetation growth with minimal fluctuations, with a growth rate of 0.95 × 10−3/a (p < 0.01). PCC analysis shows a positive correlation between NDVI and key climatic elements in over 60% of the area. The areas with significant vegetation growth had the highest average PCC. PCA and PLS-SEM identify temperature and precipitation as primary growth drivers, while elevation and land use intensity hinder growth. The MJB landscape reveals thresholds and tipping points, with specific temperature and precipitation benchmarks varying by elevation, delineating the boundary between flourishing vegetation and growth inhibition.