Extending the single photon transmission distance is a basic requirement for the implementation of quantum communication on a global scale. In this work we report the single photon exchange from a medium Earth orbit satellite (MEO) at more than 7000 km of slant distance to the ground station at the Matera Laser Ranging Observatory. The single photon transmitter was realized by exploiting the corner cube retro-reflectors mounted on the LAGEOS-2 satellite. Long duration of data collection is possible with such altitude, up to 43 minutes in a single passage. The mean number of photons per pulse (µsat) has been limited to 1 for 200 seconds, resulting in an average detection rate of 3.0 counts/s and a signal to noise ratio of 1.5. The feasibility of single photon exchange from MEO satellites paves the way to tests of Quantum Mechanics in moving frames and to global Quantum Information.Introduction -Quantum Communications (QC) are necessary for tests on the foundation of Quantum Physics, such as Bell's inequalities violation [1][2][3], entanglement swapping [4,5] and distribution [6], and quantum teleportation [7]. Moreover, the transmission of light quanta over long distances is crucial for the realization of several Quantum Information protocols, as quantum key distribution (QKD) [8][9][10], quantum authentication [11] and quantum digital signature [12].