Quantum Biology Research Meets Pathophysiology and Therapeutic Mechanisms: A Biomedical Perspective

Abstract

The recent advances of quantum biology suggest a potential role in biomedical research. Studies related to electromagnetic fields, proton pumping in mitochondrial respiratory chain, quantum theory of T-cell receptor (TCR)-degeneracy, theories on biophotons, pyrophosphates or tubulin as possible carriers for neural information, and quantum properties of ions and protons, might be useful for understanding mechanisms of some serious immune, cardiovascular, and neural pathologies for which classic biomedical research, based on biochemical approach, is struggling to find new therapeutic strategies. A breakthrough in medical knowledge is therefore needed in order to improve the understanding of the complex interactions among various systems and organs typical of such pathologies. In particular, problems related to immune system over-activation, to the role of autonomic nervous system (ANS) dysfunction in the obstructive sleep apnea (OSA) syndrome, to the clinical consequences of ion channels dysfunction and inherited cardiac diseases, could benefit from the new perspective provided by quantum biology advancement. Overall, quantum biology might provide a promising biophysical theoretic system, on which to base pathophysiology understanding and hopefully therapeutic strategies. With the present work, authors hope to open a constructive and multidisciplinary debate on this important topic.

Quantum based effects of therapeutic nuclear magnetic resonance persistently reduce glycolysis

“…1 , 2 , 3 , 4 Knowledge on the underlying mechanisms is still scarce, although several groups increasingly focus on underlying quantum mechanical effects such as the RPM. 2 , 24 , 25 , 28 Even less known are any potential physiological consequences arising from the impact of EMF's on circadian clocks. Previously, we were able to show that tNMR did not only affect clock protein members in mammalian NIH3T3 cells, but also HIF-1α, 4 which is known to be tightly linked to the circadian clock.…”

“…However, metabolic reprogramming as a therapeutic tool seems promising and has already repeatedly been suggested. 28 , 49 , 50 The increased HIF-1α driven glycolytic flux, which is commonly accompanied by increased lactate concentrations, is often a problem per se in pathophysiological conditions such as inflammation, infection (Covid-19), ischemic diseases as infarct and stroke, and also in tumor development and progression. The present study implicates that tNMR might have the potential to counteract the Warburg effect known from many cancer cells which are prone to glycolysis even under aerobic conditions.…”

Magnetic Field Intervention Enhances Cellular Migration Rates in Biological Scaffolds

“…Physiological applications for ROS and QB exist in not only tissue engineering but also neurodegeneration and aging models [62,63]. Because of the parallel RF oscillating magnetic field's ability to modulate ROS production, there is an avenue for treating certain diseases such as Alzheimer's Disease (AD).…”

The complexities of ligand/receptor interactions: Exploring the role of molecular vibrations and quantum tunnelling

“…Beyond pharmacology, there is increasing consensus in the scientific community in favor of the idea that quantum biology is poised to contribute to the medical sciences sooner rather than later. [113][114][115] An intriguing example of a medical problem that could be directly studied using quantum mechanical principles is the proposal that quantum tunneling is part of the mechanism of infection by the SARSCoV2 (COVID-19) virus, [116] a tantalizing possibility with immediately apparent public health applications.…”