Particle fluctuations in mesoscopic Bose systems of arbitrary spatial dimensionality are considered. Both ideal Bose gases and interacting Bose systems are studied in the regions above the Bose-Einstein condensation temperature T c as well as below this temperature. The strength of particle fluctuations defines whether the system is stable or not. Stability conditions depend on the spatial dimensionality d and on the confining dimension D of the system. The consideration shows that mesoscopic systems, experiencing Bose-Einstein condensation, are stable when: (i) ideal Bose gas is confined in a rectangular box of spatial dimension d > 2 above T c and in a box of d > 4 below T c ; (ii) ideal Bose gas is confined in a power-law trap of a confining dimension D > 2 above T c and of a confining dimension D > 4 below T c ; (iii) interacting Bose system is confined in a rectangular box of dimension d > 2 above T c , while below T c particle interactions stabilize the Bose-condensed system making it stable for d = 3; (iv) nonlocal interactions diminish the condensation temperature, as compared with the fluctuations in a system with contact interactions.