Quantum Dot-Based Biosensor for Detection of Human Cardiac Troponin I Using a Liquid-Core Waveguide

Stringer, R. Cody; Hoehn, Daniel; Grant, Sheila

doi:10.1109/jsen.2008.917489

Cited by 35 publications

(23 citation statements)

References 22 publications

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“…of Pages 7 [25] semiconductor surface. Examples of devices built on such a principle include colloidal QDs of CdSe, ZnS, CdS, ZnSe, CdTe and PbSe [26][27][28][29] and bulk GaAs [30][31][32]. Protection (passivation) of cleaned and etched surfaces of semiconductors from oxidization plays an important role in functioning of PL-based biosensors [33], and investigation of electronic or photonic properties of semiconductors surrounded by aqueous environments [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

GaAs/AlGaAs heterostructure based photonic biosensor for rapid detection of Escherichia coli in phosphate buffered saline solution

Nazemi

Aithal

Hassen

et al. 2015

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

GaAs/AlGaAs heterostructure based photonic biosensor for rapid detection of Escherichia coli in phosphate buffered saline solution

Nazemi

Aithal

Hassen

et al. 2015

Sensors and Actuators B: Chemical

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“…Beyond nucleic acid assays, a unimolecular immunoassay strategy was reported by Stringer et al and relied on conformational changes to modulate QD-FRET [255]. Human cardiac troponin I (cTnI) was the analyte of interest and QD545 were conjugated with anti-cTnI using a protein A bridge.…”

Section: Changes In Distance To Modulate Qd-fretmentioning

confidence: 99%

Semiconductor Quantum Dots and FRET

Algar

Massey

Krull

2013

FRET – Förster Resonance Energy Transfer

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Quantum dots (QDs) are one of the most interesting new materials that have emerged over the last 20 years. These brightly luminescent nanoparticles have garnered significant attention from researchers working in the fields of biology, chemistry, physics, engineering, and at the interface between these fields. A powerful spectroscopic tool that also spans these disciplines is F€ orster resonance energy transfer (FRET). In this chapter, the compelling partnership between quantum dots and FRET is considered at both the fundamental and applied levels, emphasizing utility in biological applications. The text begins with a short review of FRET in Section 12.2, which reiterates the basic equations that relate physical parameters to experimental observables. Conventional FRET with a well-defined donor-acceptor pair serves as a reference point for comparison with quantum dots. Next, Section 12.3 describes the structure, chemistry, and optical properties of quantum dots. The purpose of this section is threefold: (i) impart the reasons for the widespread interest in quantum dots; (ii) outline the methods for using quantum dots as functional materials in biological applications; and (iii) provide a primer on quantum dot photophysics, which clearly have an important role in energy transfer. Cumulatively, Sections 12.2-12.3 provide sufficient background to fully appreciate the utility, advantages, and disadvantages of FRET with quantum dots, which are discussed in Section 12.4. Adherence and potential departures from the F€ orster formalism are also discussed. Section 12.5 provides a comprehensive review of the use of quantum dots as FRET donors in biological applications. These applications include assays, biosensing and chemosensing, distance measurements/conformational studies, and photodynamic therapy. Ensemble, single-pair, and solid-phase FRET configurations are considered. Section 12.6 reviews similar applications of quantum dot acceptors with chemiluminescent, bioluminescent, or lanthanide donors. Energy transfer between quantum dots and other nanomaterials is reviewed in Section 12.7; these mechanisms are similar to the F€ orster mechanism, but not strictly equivalent. Several examples of biological applications are given.

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“…For instance, Stringer et al developed a biosensor that is able to detect troponin I to diagnose early injuries of cardiac muscles (Stringer et al, 2008) and also to detect small amounts of nitrated ceruloplasmin (a significant biomarker for cardiovascular disease, lung cancer, and Quantum Dots in Biomedical Research 283 stress response to smoking) (Pyo & Yoo, 2012). Another interesting application is described by Krull et al which performed solid-phase hybridization assays aiming multiplexed nucleic acid diagnostics using QDs as donors in FRET processes (Algar & Krull, 2008;Medintz & Mattoussi, 2009).…”

Section: Quantum Dots As Probes In Other Bioassaysmentioning

confidence: 99%