Quantum Dots Conjugated with Transferrin for Brain Tumor Cell Imaging

Tsukamoto, Hiroshi Yukawa Ryoko

doi:10.4172/2157-7013.1000150

Cited by 7 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…QDs are semiconductor nanocrystals with a photostability up to 100-10000 fold greater than conventional organic dyes. Unluckily, because QDs are heavy metals, they may lead to potential toxicities, but their encapsulation in liposomes may improve their biocompatibility to become a potential tool for diagnostics in in vitro and in vivo tumor models [136]. TPGS, a derivative of the natural vitamin E (alpha-tocopherol), has shown great potential in overcoming the P-gp via inhibition of its ATPase activity [42].…”

Section: Cancermentioning

confidence: 99%

Liposomal Drug Delivery to the Central Nervous System

Nieto-Montesinos¹

2017

Liposomes

View full text Add to dashboard Cite

Central nervous system diseases represent a huge world of burden of human suffering with negative economic results. Most therapeutic compounds cannot attain the brain because of the blood-brain barrier and its expression of efflux transporters. Among them, the P-glycoprotein plays a significant role leading to failure of various clinical treatments. A non-invasive strategy to circumvent the blood-brain barrier and P-glycoprotein emphasizes on the encapsulation and therefore masking of therapeutic compounds in drug delivery systems. Up to now, liposomes are the most widely studied drug delivery systems due to their biocompatibility, biodegradability, and less toxicity. The incorporation of polyethylene glycol-lipid derivatives within the bilayer of conventional liposomes significantly prolongs liposomal cargo half-life by steric stabilization. Interestingly, an increased brain accumulation of liposomal cargo is achieved by coupling targeting moieties on liposomes surface. These targeting moieties such as peptides or monoclonal antibodies recognize the biochemical transport systems at the blood-brain barrier and mediate the transport of liposomes and their cargo across this barrier. Moreover, stimuli-sensitive liposomes are programmed for cargo release when exposed to a particular microenvironment. Hence, this chapter highlights the potential liposomal applications for delivery of therapeutic compounds as well as diagnostic tools or both, in major central nervous system diseases.

show abstract

Section: Cancermentioning

confidence: 99%

Liposomal Drug Delivery to the Central Nervous System

Nieto-Montesinos¹

2017

Liposomes

View full text Add to dashboard Cite

show abstract

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

et al. 2016

View full text Add to dashboard Cite

Functionalization enhances the properties and characteristics of nanoparticles through surface modification, and enables them to play a major role in the field of medicine. In molecular imaging, quality functional images are required with proper differentiation which can be seen with high contrast to obtain viable information. This review article discusses how functionalization enhances molecular imaging and enables multimodal imaging by which images with combination of functions particular to each modality can be obtained. This also explains how nanoparticles interacting at molecular level, when functionalized with molecules can target the cells of interest or substances with high specificity, reducing background signal and allowing simultaneous therapies to be carried out while imaging. Functionalization allows imaging for a prolonged period and enables to track the cells over a period of time. Recent researches and progress in functionalizing the nanoparticles to specifically enhance bioimaging with different modalities and their applications are reviewed in this article.

show abstract

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends

Choudhury

Pandey

Chin

et al. 2018

Drug Deliv. and Transl. Res.

149

View full text Add to dashboard Cite

Treatment of glioblastoma multiforme (GBM) is a predominant challenge in chemotherapy due to the existence of blood-brain barrier (BBB) which restricts delivery of chemotherapeutic agents to the brain together with the problem of drug penetration through hard parenchyma of the GBM. With the structural and mechanistic elucidation of the BBB under both physiological and pathological conditions, it is now viable to target central nervous system (CNS) disorders utilizing the presence of transferrin (Tf) receptors (TfRs). However, overexpression of these TfRs on the GBM cell surface can also help to avoid restrictions of GBM cells to deliver chemotherapeutic agents within the tumor. Therefore, targeting of TfR-mediated delivery could counteract drug delivery issues in GBM and create a delivery system that could cross the BBB effectively to utilize ligand-conjugated drug complexes through receptor-mediated transcytosis. Hence, approach towards successful delivery of antitumor agents to the gliomas has been making possible through targeting these overexpressed TfRs within the CNS and glioma cells. This review article presents a thorough analysis of current understanding on Tf-conjugated nanocarriers as efficient drug delivery system.

show abstract

Quantum Dots Conjugated with Transferrin for Brain Tumor Cell Imaging

Cited by 7 publications

References 23 publications

Liposomal Drug Delivery to the Central Nervous System

Liposomal Drug Delivery to the Central Nervous System

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends

Contact Info

Product

Resources

About