2021
DOI: 10.1021/acs.jpcb.0c11545
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Quantum Dots for Improved Single-Molecule Localization Microscopy

Abstract: Colloidal semiconductor quantum dots (QDs) have long established their versatility and utility for the visualization of biological interactions. On the single-particle level, QDs have demonstrated superior photophysical properties compared to organic dye molecules or fluorescent proteins, but it remains an open question as to which of these fundamental characteristics are most significant with respect to the performance of QDs for imaging beyond the diffraction limit. Here, we demonstrate significant enhanceme… Show more

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Cited by 17 publications
(22 citation statements)
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“…Semiconductor quantum dots (QDs) combine advantageous aspects of both homogeneous (high surface–volume ratio, solubility in reaction media, light penetration) and heterogeneous (durability, substrate binding) catalysts, and therefore offer new opportunities for photoredox catalysis. , QDs have proven to be robust fluorophores and photocatalysts, generally exhibiting superior photostability to small-molecule dyes; however, applications of QDs to organic synthesis remain underexplored. To address the need for continued development of photoredox catalysts, our group and others have been interested in new applications of QDs in organic chemistry. , In addition to their high photostability, QDs exhibit tunable, size-dependent optical and redox properties; are made in single-step syntheses with no chromatography from abundant precursors; reversibly bind to many molecules at once (typically 1–5 ligands/nm 2 of QD surface are found for CdSe QDs ) through common organic functional groups (−CO 2 H, −PO 3 H, −SH, −NH 2 ); can become charged with many electrons at once without decomposing; , and undergo many electronic processes with no direct analogue in small molecules …”
Section: Introductionmentioning
confidence: 99%
“…Semiconductor quantum dots (QDs) combine advantageous aspects of both homogeneous (high surface–volume ratio, solubility in reaction media, light penetration) and heterogeneous (durability, substrate binding) catalysts, and therefore offer new opportunities for photoredox catalysis. , QDs have proven to be robust fluorophores and photocatalysts, generally exhibiting superior photostability to small-molecule dyes; however, applications of QDs to organic synthesis remain underexplored. To address the need for continued development of photoredox catalysts, our group and others have been interested in new applications of QDs in organic chemistry. , In addition to their high photostability, QDs exhibit tunable, size-dependent optical and redox properties; are made in single-step syntheses with no chromatography from abundant precursors; reversibly bind to many molecules at once (typically 1–5 ligands/nm 2 of QD surface are found for CdSe QDs ) through common organic functional groups (−CO 2 H, −PO 3 H, −SH, −NH 2 ); can become charged with many electrons at once without decomposing; , and undergo many electronic processes with no direct analogue in small molecules …”
Section: Introductionmentioning
confidence: 99%
“…Synthesis of the QDs occurred on a Schlenk line under N2 with heating and stirring. Briefly, CdSe cores were synthesized from a protocol adapted from those previously reported, where Cd and Se precursors were reacted with various coordinating ligands where after a brief nucleation step at elevated temperature, the nanocrystals were annealed for up to 2 hours to achieve desired core size, as determined by absorbance and PL (15, 83). The CdSe QD cores were washed and then shelled with CdS following a protocol adapted from those previously reported, where Cd and S precursors were slowly injected via a dual-syringe pump (15, 84, 85).…”
Section: Methodsmentioning
confidence: 99%
“…Briefly, CdSe cores were synthesized from a protocol adapted from those previously reported, where Cd and Se precursors were reacted with various coordinating ligands where after a brief nucleation step at elevated temperature, the nanocrystals were annealed for up to 2 hours to achieve desired core size, as determined by absorbance and PL (15, 83). The CdSe QD cores were washed and then shelled with CdS following a protocol adapted from those previously reported, where Cd and S precursors were slowly injected via a dual-syringe pump (15, 84, 85). The final CdSe/CdS core/shell QDs were then encapsulated into self-assembled micelles formed by a polymerized phospholipid ligand with a bis-sulfone functional group (PE:PEG:bis-sulfone).…”
Section: Methodsmentioning
confidence: 99%
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“…Semiconductor quantum dots (QDs) combine advantageous aspects of both homogeneous (high surface-volume ratio, solubility in reaction media, light penetration) and heterogeneous (durability, substrate binding) catalysts, and therefore offer new opportunities for photoredox catalysis. 25,26 QDs have proven to be robust fluorophores and photocatalysts, generally exhibiting superior photostability to small-molecule dyes, [27][28][29][30][31][32][33] however applications of QDs to organic synthesis remain underexplored. To address the need for continued development of photoredox catalysts, our group and others have been interested in new applications of QDs in organic chemistry.…”
Section: Introductionmentioning
confidence: 99%