“…Recent research findings have not only verified the feasibility of optical communication in neural circuits but also provided an important basis for establishing a theoretical model of optical communication between nerve fibers ( Kumar et al, 2016 ; Zangari et al, 2018 ; Zarkeshian et al, 2018 ; Ambrosetti et al, 2022 ). Moreover, experimental results have shown that near infrared laser photons induce glutamate release from nerve terminals, and the quantum energy level of glutamate modulate neural biophotonic activity and transmission ( Amaroli et al, 2018 ; Xiang et al, 2020 ; Han et al, 2021 ; Maghoul et al, 2021 ). In the present study, reduced biophotonic activities and spectral blueshift induced by glutamate were found in synaptosomes and brain slices from AD and VaD model animals, indicating that this biophoton imaging technology is accurate and effective in assessing functional changes in synapses and neural circuits.…”