Industry 4.0 is the most disruptive revolution engulfing all the digital transformation from sensors nodes to cloud applications. A sustainable and secure Industry 4.0 ecosystem is a core challenge for stakeholders and state agencies addressed in this work by layered API tunnel interoperability instead of conventional cybersecurity methods and techniques. In this work, an interoperable application programmer interface (API) wrapper is being proposed to manage heterogeneous cloud architectures using Eucalyptus, Apache CloudStack, and OpenNebula. A comprehensive design and implementation plan from things layer to user interface has been accomplished in this work. Infrastructure as a Service (IaaS) is being automated using Ansible from Web Servers Layers through Common Gateway Interface (CGI) scripting. The Web Servers are being managed using WebSockets by micro–Web Servers Gateway Interface (uWSGI) from cloudstack managers (CSM) API. The Platform as a Service (PaaS) for big data, web servers, and machine learning platforms is accomplished using uWSGI from CSM. The public and private clouds are being managed using individual APIs. The wrapper, proposed in this work enables the big challenge of Industry 4.0 for realizing interoperability, scalability, heterogeneity, and automated cloud integration by functioning at the Software as a Service (SaaS) Layer.