It
is well understood that the creative processes behind art forms,
including music, are highly subjective and are based on personal interpretation.
This raises the question: can music be effectively integrated into
the teaching of more objective subjects, such as chemistry, if done
through a systematic and structured framework? In this work, we rationally
constructed the mapping between small molecules and chords. We found
a strong correlation between the molecular stability and the music
type from the interpretation of chemical bonding pictures. This correlation
helps students understand the beauty and artistry of chemistry and
chords in music. Furthermore, we observed some small imperfections
in the molecule mappings of certain real-world chord progressions,
which present opportunities for refinement through optimization of
the underlying molecular cohesive energy. We demonstrated that the
basic chemical bonding picture could provide objective understanding
or even standards for music composing. Most small-molecule structures,
such as amino acids, can be objectively transformed into reasonable
chord combinations, and some real-world music chords exist in these
molecular chords. Therefore, students can “play” the
molecules using real instruments, and this method is practicable in
organic chemistry education.