This paper is an introduction to the special issue of the 7th Int. Conf. on Unsolved Problems on Noise (UPoN) that took place at Casa Convalescència in Barcelona (Spain) in July 2015. The aim of the UPoN conferences is to provide a forum for researchers working on different fields of noise, fluctuations and variability, where they present their scientific problems which resist solutions. The papers of this Special Issue reflect the interdisciplinary topics (physics, biology, circuits, financial markets, psychology, technology, etc) presented at the UPoN conference. Noise is not only a hindrance to signal detection, but it is indeed a valuable source of information (not present in the signal) that help us to get a deeper understanding on how Nature works.